product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human IL-17A (Human Cell-expressed) Protein
catalog :
7955-IL-025
quantity :
25 ug (also 50 ug, 200 ug, 1 mg)
price :
322 USD
more info or order :
R&D Systems product webpage
citations: 17
Reference
Sigutova V, Xiang W, Regensburger M, Winner B, Prots I. Alpha-synuclein fine-tunes neuronal response to pro-inflammatory cytokines. Brain Behav Immun. 2024;122:216-230 pubmed publisher
Jin B, Moududee S, Ge D, Zhou P, Wang A, Liu Y, et al. SCFFBXW11 Complex Targets Interleukin-17 Receptor A for Ubiquitin-Proteasome-Mediated Degradation. Biomedicines. 2024;12: pubmed publisher
Cao Q, Ishak M, Shpilman I, Hirota J. TNF-α and Poly(I:C) induction of A20 and activation of NF-κB signaling are independent of ABCF1 in human airway epithelial cells. Sci Rep. 2023;13:14745 pubmed publisher
Pavlidis P, Tsakmaki A, Treveil A, Li K, Cozzetto D, Yang F, et al. Cytokine responsive networks in human colonic epithelial organoids unveil a molecular classification of inflammatory bowel disease. Cell Rep. 2022;40:111439 pubmed publisher
Margetts G, Kleidonas S, Zaibi N, Zaibi M, Edwards K. Evidence for anti-inflammatory effects and modulation of neurotransmitter metabolism by Salvia officinalis L. BMC Complement Med Ther. 2022;22:131 pubmed publisher
Byrne E, Llorián Salvador M, Tang M, Margariti A, Chen M, Xu H. IL-17A Damages the Blood-Retinal Barrier through Activating the Janus Kinase 1 Pathway. Biomedicines. 2021;9: pubmed publisher
Sinkeviciute D, Aspberg A, He Y, Bay Jensen A, nnerfjord P. Characterization of the interleukin-17 effect on articular cartilage in a translational model: an explorative study. BMC Rheumatol. 2020;4:30 pubmed publisher
Sun L, Girnary M, Wang L, Jiao Y, Zeng E, Mercer K, et al. IL-10 Dampens an IL-17-Mediated Periodontitis-Associated Inflammatory Network. J Immunol. 2020;204:2177-2191 pubmed publisher
Heath J, Scholz G, Veith P, Reynolds E. IL-36γ regulates mediators of tissue homeostasis in epithelial cells. Cytokine. 2019;119:24-31 pubmed publisher
Muntaka S, Almuhanna Y, Jackson D, Singh S, Afryie Asante A, Camara M, et al. Gamma Interferon and Interleukin-17A Differentially Influence the Response of Human Macrophages and Neutrophils to Pseudomonas aeruginosa Infection. Infect Immun. 2019;87: pubmed publisher
Chorachoo J, Lambert S, Furnholm T, Roberts L, Reingold L, Auepemkiate S, et al. The small molecule rhodomyrtone suppresses TNF-α and IL-17A-induced keratinocyte inflammatory responses: A potential new therapeutic for psoriasis. PLoS ONE. 2018;13:e0205340 pubmed publisher
Anderson E, Sastalla I, Earland N, Mahnaz M, Moore I, Otaizo Carrasquero F, et al. Prolonging culture of primary human keratinocytes isolated from suction blisters with the Rho kinase inhibitor Y-27632. PLoS ONE. 2018;13:e0198862 pubmed publisher
Bambousková M, Gorvel L, Lampropoulou V, Sergushichev A, Loginicheva E, Johnson K, et al. Electrophilic properties of itaconate and derivatives regulate the IκBζ-ATF3 inflammatory axis. Nature. 2018;556:501-504 pubmed publisher
Stanfield B, Rider P, Caskey J, Del Piero F, Kousoulas K. Intramuscular vaccination of guinea pigs with the live-attenuated human herpes simplex vaccine VC2 stimulates a transcriptional profile of vaginal Th17 and regulatory Tr1 responses. Vaccine. 2018;36:2842-2849 pubmed publisher
Tusi B, Wolock S, Weinreb C, Hwang Y, Hidalgo D, Zilionis R, et al. Population snapshots predict early haematopoietic and erythroid hierarchies. Nature. 2018;555:54-60 pubmed publisher
Swindell W, Beamer M, Sarkar M, Loftus S, Fullmer J, Xing X, et al. RNA-Seq Analysis of IL-1B and IL-36 Responses in Epidermal Keratinocytes Identifies a Shared MyD88-Dependent Gene Signature. Front Immunol. 2018;9:80 pubmed publisher
Yuki T, Tobiishi M, Kusaka Kikushima A, Ota Y, Tokura Y. Impaired Tight Junctions in Atopic Dermatitis Skin and in a Skin-Equivalent Model Treated with Interleukin-17. PLoS ONE. 2016;11:e0161759 pubmed publisher
product information
brand :
R&D Systems
catalog number base :
7955-IL
SKU :
7955-IL-025
product name :
Recombinant Human IL-17A (Human Cell-expressed) Protein
units size :
25 ug (also 50 ug, 200 ug, 1 mg)
description :
The Recombinant Human IL-17A (Human Cell-expressed) Protein from R&D Systems is derived from HEK293. The Recombinant Human IL-17A (Human Cell-expressed) Protein has been validated for the following applications: Bioactivity.
target :
IL-17/IL-17A
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.
conjugate :
Unconjugated
all_available conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Human
observed molecular weight :
15-23 kDa, reducing conditions 28-38 kDa, non-reducing conditions
theoretical molecular weight :
15.1 kDa (monomer)
gene symbol :
IL17A
details of functionality :
Measured by its ability to induce CXCL1/GRO alpha secretion in HT-29 human colon adenocarcinoma cells. The ED50 for this effect is 0.12-1.2 ng/mL. Measured by its ability to induce IL-6 secretion by NIH-3T3 mouse embryonic fibroblast cells. Yao, Z. et al . (1995) Immunity 3 :811. The ED50 for this effect is 1.5-7.5 ng/mL.
endotoxin note :
<0.01 EU per 1 µg of the protein by the LAL method.
top caption :
Recombinant Human IL-17A (Human Cell-expressed) Protein Bioactivity
accessionNumbers :
Q16552
applications :
Bioactivity
source :
HEK293-derived Recombinant Human IL-17A (Human Cell-expressed) Protein
USD :
322 USD
alt names :
CTLA8, CTLA-8, CTLA8cytotoxic T-lymphocyte-associated serine esterase 8, Cytotoxic T-lymphocyte-associated antigen 8, IL17, IL17A, IL-17A, IL-17Acytotoxic T-lymphocyte-associated protein 8, IL-17CTLA-8, IL17interleukin-17A, interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8), interleukin 17A
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.