Recombinant Human CXCL4/PF4 Protein, CF | R&D Systems 795-P4 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human CXCL4/PF4 Protein, CF

catalog :

795-P4

quantity :

25 ug

price :

329 USD

citations: 12

Reference
Ojha A, Bhasym A, Mukherjee S, Annarapu G, Bhakuni T, Akbar I, et al. Platelet factor 4 promotes rapid replication and propagation of Dengue and Japanese encephalitis viruses. EBioMedicine. 2019;39:332-347 pubmed publisher
Daly C, Qian X, Castanaro C, Pasnikowski E, Jiang X, Thomson B, et al. Angiopoietins bind thrombomodulin and inhibit its function as a thrombin cofactor. Sci Rep. 2018;8:505 pubmed publisher
Schludi B, Moin A, Montemurro C, Gurlo T, Matveyenko A, Kirakossian D, et al. Islet inflammation and ductal proliferation may be linked to increased pancreatitis risk in type 2 diabetes. JCI Insight. 2017;2: pubmed publisher
Bronger H, Karge A, Dreyer T, Zech D, Kraeft S, Avril S, et al. Induction of cathepsin B by the CXCR3 chemokines CXCL9 and CXCL10 in human breast cancer cells. Oncol Lett. 2017;13:4224-4230 pubmed publisher
Schneider R, Mullally A, Dugourd A, Peisker F, Hoogenboezem R, van Strien P, et al. Gli1+ Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target. Cell Stem Cell. 2017;20:785-800.e8 pubmed publisher
Ollivier V, Syvannarath V, Gros A, Butt A, Loyau S, Jandrot Perrus M, et al. Collagen can selectively trigger a platelet secretory phenotype via glycoprotein VI. PLoS ONE. 2014;9:e104712 pubmed publisher
Guzzo C, Fox J, Lin Y, Miao H, Cimbro R, Volkman B, et al. The CD8-derived chemokine XCL1/lymphotactin is a conformation-dependent, broad-spectrum inhibitor of HIV-1. PLoS Pathog. 2013;9:e1003852 pubmed publisher
Balan M, Pal S. A novel CXCR3-B chemokine receptor-induced growth-inhibitory signal in cancer cells is mediated through the regulation of Bach-1 protein and Nrf2 protein nuclear translocation. J Biol Chem. 2014;289:3126-37 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Zhu Y, Vergote D, Pardo C, Noorbakhsh F, McArthur J, Hollenberg M, et al. CXCR3 activation by lentivirus infection suppresses neuronal autophagy: neuroprotective effects of antiretroviral therapy. FASEB J. 2009;23:2928-41 pubmed publisher
Datta D, Flaxenburg J, Laxmanan S, Geehan C, Grimm M, Waaga Gasser A, et al. Ras-induced modulation of CXCL10 and its receptor splice variant CXCR3-B in MDA-MB-435 and MCF-7 cells: relevance for the development of human breast cancer. Cancer Res. 2006;66:9509-18 pubmed
Nakayama T, Shirane J, Hieshima K, Shibano M, Watanabe M, Jin Z, et al. Novel antiviral activity of chemokines. Virology. 2006;350:484-92 pubmed

product information

brand :

R&D Systems

master code :

795-P4

SKU :

795-P4-025/CF

product name :

Recombinant Human CXCL4/PF4 Protein, CF

description :

The Recombinant Human CXCL4/PF4 Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human CXCL4/PF4 Protein, CF has been validated for the following applications: Bioactivity.

target :

CXCL4/PF4

category :

Proteins and Enzymes

unit size :

25 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

theoretical molecular weight :

7.8 kDa

gene symbol :

PF4

details of functionality :

Measured by its ability to inhibit the FGF basic-dependent proliferation of HUVEC human umbilical vein endothelial cells. Dubrac, A. et al . (2010) Blood 116 :4703. The ED50 for this effect is 2-10 µg/mL.

endotoxin note :

<0.01 EU per 1 µg of the protein by the LAL method.

catalog number base :

795-P4/CF

accessionNumbers :

P02776.2

applications :

Bioactivity

source :

E. coli -derived human CXCL4/PF4 protein Glu32-Ser101

2020 USD :

329

2021 USD :

329 USD

alt names :

chemokine (C-X-C motif) ligand 4, C-X-C motif chemokine 4, CXCL4iroplact, Iroplact, MGC138298, Oncostatin-A, PF4, PF-4, platelet factor 4, SCYB4oncostatin-A

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.