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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse IGF-II/IGF2 Protein, CF
catalog :
792-MG-050
quantity :
50 ug
price :
240 USD
more info or order :
citations: 26
Reference
Krummeich J, Nardi L, Caliendo C, Aschauer D, Engelhardt V, Arlt A, et al. Premature cognitive decline in a mouse model of tuberous sclerosis. Aging Cell. 2024;23:e14318 pubmed publisher
Li T, Yang F, Heng Y, Zhou S, Wang G, Wang J, et al. TMED10 mediates the trafficking of insulin-like growth factor 2 along the secretory pathway for myoblast differentiation. Proc Natl Acad Sci U S A. 2023;120:e2215285120 pubmed publisher
Shimizu K, Kikuta J, Ohta Y, Uchida Y, Miyamoto Y, Morimoto A, et al. Single-cell transcriptomics of human cholesteatoma identifies an activin A-producing osteoclastogenic fibroblast subset inducing bone destruction. Nat Commun. 2023;14:4417 pubmed publisher
Qiu Q, Yang L, Feng Y, Zhu Z, Li N, Zheng L, et al. HDAC I/IIb selective inhibitor Purinostat Mesylate combined with GLS1 inhibition effectively eliminates CML stem cells. Bioact Mater. 2023;21:483-498 pubmed publisher
Kondo T, Aoki H, Otsuka Y, Kawaguchi Y, Waguri Nagaya Y, Aoyama M. Insulin-like growth factor 2 promotes osteoclastogenesis increasing inflammatory cytokine levels under hypoxia. J Pharmacol Sci. 2022;149:93-99 pubmed publisher
Berg E, Petkova S, Born H, Adhikari A, Anderson A, Silverman J. Insulin-like growth factor-2 does not improve behavioral deficits in mouse and rat models of Angelman Syndrome. Mol Autism. 2021;12:59 pubmed publisher
Michaux H, Halouani A, Trussart C, Renard C, Jaïdane H, Martens H, et al. Modulation of IGF2 Expression in the Murine Thymus and Thymic Epithelial Cells Following Coxsackievirus-B4 Infection. Microorganisms. 2021;9: pubmed publisher
Wang Z, Cui M, Shah A, Tan W, Liu N, Bassel Duby R, et al. Cell-Type-Specific Gene Regulatory Networks Underlying Murine Neonatal Heart Regeneration at Single-Cell Resolution. Cell Rep. 2020;33:108472 pubmed publisher
Lee K, Aitken J, Hsu H, Williams G, Brimble M, Cooper G. Glucoregulatory activity of vesiculin in insulin sensitive and resistant mice. Peptides. 2019;116:1-7 pubmed publisher
De Giovanni C, Nanni P, Landuzzi L, Ianzano M, Nicoletti G, Croci S, et al. Immune targeting of autocrine IGF2 hampers rhabdomyosarcoma growth and metastasis. BMC Cancer. 2019;19:126 pubmed publisher
Periasamy P, Tran V, O Neill H. Identification of genes which regulate stroma-dependent in vitro hematopoiesis. PLoS ONE. 2018;13:e0205583 pubmed publisher
Wang M, Chen F, Liu Q, Liu C, Yao H, Yu B, et al. Insulin-like growth factor 2 is a key mitogen driving liver repopulation in mice. Cell Death Dis. 2018;9:26 pubmed publisher
Steinmetz A, Stern S, Kohtz A, Descalzi G, Alberini C. Insulin-Like Growth Factor II Targets the mTOR Pathway to Reverse Autism-Like Phenotypes in Mice. J Neurosci. 2018;38:1015-1029 pubmed publisher
Pardo M, Cheng Y, Velmeshev D, Magistri M, Eldar Finkelman H, Martinez A, et al. Intranasal siRNA administration reveals IGF2 deficiency contributes to impaired cognition in Fragile X syndrome mice. JCI Insight. 2017;2:e91782 pubmed publisher
Nakatsuka R, Iwaki R, Matsuoka Y, Sumide K, Kawamura H, Fujioka T, et al. Identification and Characterization of Lineage(-)CD45(-)Sca-1(+) VSEL Phenotypic Cells Residing in Adult Mouse Bone Tissue. Stem Cells Dev. 2016;25:27-42 pubmed publisher
Casellas A, Mallol C, Salavert A, Jimenez V, Garcia M, Agudo J, et al. Insulin-like Growth Factor 2 Overexpression Induces β-Cell Dysfunction and Increases Beta-cell Susceptibility to Damage. J Biol Chem. 2015;290:16772-85 pubmed publisher
Ikemoto Uezumi M, Uezumi A, Tsuchida K, Fukada S, Yamamoto H, Yamamoto N, et al. Pro-Insulin-Like Growth Factor-II Ameliorates Age-Related Inefficient Regenerative Response by Orchestrating Self-Reinforcement Mechanism of Muscle Regeneration. Stem Cells. 2015;33:2456-68 pubmed publisher
Shi Y, Chen J, Karner C, Long F. Hedgehog signaling activates a positive feedback mechanism involving insulin-like growth factors to induce osteoblast differentiation. Proc Natl Acad Sci U S A. 2015;112:4678-83 pubmed publisher
Shaw A, Pickup M, Chytil A, Aakre M, Owens P, Moses H, et al. TGFβ signaling in myeloid cells regulates mammary carcinoma cell invasion through fibroblast interactions. PLoS ONE. 2015;10:e0117908 pubmed publisher
Yang G, Geng X, Song J, Wu Y, Yan H, Zhan Z, et al. Insulin-like growth factor 2 enhances regulatory T-cell functions and suppresses food allergy in an experimental model. J Allergy Clin Immunol. 2014;133:1702-8.e5 pubmed publisher
Ziegler A, Chidambaram S, Forbes B, Wood T, Levison S. Insulin-like growth factor-II (IGF-II) and IGF-II analogs with enhanced insulin receptor-a binding affinity promote neural stem cell expansion. J Biol Chem. 2014;289:4626-33 pubmed publisher
Chen D, Stern S, Garcia Osta A, Saunier Rebori B, Pollonini G, Bambah Mukku D, et al. A critical role for IGF-II in memory consolidation and enhancement. Nature. 2011;469:491-7 pubmed publisher
Ostrovsky O, Ahmed N, Argon Y. The chaperone activity of GRP94 toward insulin-like growth factor II is necessary for the stress response to serum deprivation. Mol Biol Cell. 2009;20:1855-64 pubmed publisher
Zhang P, Nelson S, Bagby G, Siggins R, Shellito J, Welsh D. The lineage-c-Kit+Sca-1+ cell response to Escherichia coli bacteremia in Balb/c mice. Stem Cells. 2008;26:1778-86 pubmed publisher
Huynh H, Iizuka S, Kaba M, Kirak O, Zheng J, Lodish H, et al. Insulin-like growth factor-binding protein 2 secreted by a tumorigenic cell line supports ex vivo expansion of mouse hematopoietic stem cells. Stem Cells. 2008;26:1628-35 pubmed publisher
Tanaka H, Yamamoto M, Hashimoto N, Miyakoshi M, Tamakawa S, Yoshie M, et al. Hypoxia-independent overexpression of hypoxia-inducible factor 1alpha as an early change in mouse hepatocarcinogenesis. Cancer Res. 2006;66:11263-70 pubmed
product information
brand :
R&D Systems
master code :
792-MG
SKU :
792-MG-050
product name :
Recombinant Mouse IGF-II/IGF2 Protein, CF
unit size :
50 ug
seo description :
The Recombinant Mouse IGF-II/IGF2 Protein, CF from R&D Systems is derived from E. coli. The Recombinant Mouse IGF-II/IGF2 Protein, CF has been validated for the following applications: Bioactivity.
target :
IGF-II/IGF2
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in Acetonitrile and TFA.
conjugate :
Unconjugated
dilution :
Bioactivity
species :
Mouse
theoretical molecular weight :
7.4 kDa
gene symbol :
Igf2
details of functionality :
Measured in a serum-free cell proliferation assay using MCF-7 human breast cancer cells. Karey, K.P. et al . (1988) Cancer Research 48 :4083. The ED50 for this effect is 2-10 ng/mL.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
P09535
applications :
Bioactivity
source :
E. coli-derived Recombinant Mouse IGF-II/IGF2 Protein, CF
USD :
240 USD
alt names :
C11orf43, chromosome 11 open reading frame 43, FLJ22066, FLJ44734, GRDF, IGF2, IGF-2, IGFII, IGF-II, insulin-like growth factor 2 (somatomedin A), insulin-like growth factor II, insulin-like growth factor type 2, MSA, PEG2, PP9974, somatomedin-A
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.