product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human SMAC/Diablo Protein, CF
catalog :
789-SM-100
quantity :
100 ug
price :
468 USD
more info or order :
R&D Systems product webpage
citations: 2
Reference
Park B, Ham Y, Jeong H, Cho S, Je Y, Yoo K, et al. Phosphorylation of Smac by JNK3 attenuates its interaction with XIAP. Biochem Biophys Res Commun. 2007;361:994-9 pubmed
McNeish I, Lopes R, Bell S, McKay T, Fernandez M, Lockley M, et al. Survivin interacts with Smac/DIABLO in ovarian carcinoma cells but is redundant in Smac-mediated apoptosis. Exp Cell Res. 2005;302:69-82 pubmed
product information
master code :
789-SM
SKU :
789-SM-100
product name :
Recombinant Human SMAC/Diablo Protein, CF
unit size :
100 ug
description :
The Recombinant Human SMAC/Diablo Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human SMAC/Diablo Protein, CF has been validated for the following applications: Inhibition Activity.
target :
SMAC/Diablo
category :
Proteins and Enzymes
buffer :
Supplied as a 0.2 ╡m filtered solution in HEPES and NaCl.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Human
observed molecular weight :
23 kDa, reducing conditions
theoretical molecular weight :
22 kDa
gene symbol :
DIABLO
details of functionality :
Measured by its ability to reverse the inhibition of DEVD-AFC cleavage activity in cell extracts activated by addition of cytochrome c and dATP. The IC50 for reversal of XIAP-BIR3 (50 nM) inhibition of DEVD-AFC cleavage in activated cell extracts is 2,000 nM. Optimal dilutions should be determined by each laboratory for each application.
accessionNumbers :
Q9NR28
applications :
Inhibition Activity
source long :
E. coli -derived human SMAC/Diablo protein Ala56-Asp239, with a C-terminal 6-His tag
source short :
E. coli
USD :
468 USD
alt names :
0610041G12Rik, Diablo, diablo, IAP-binding mitochondrial protein, Direct IAP-binding protein with low pI, mitochondrial Smac protein, Second mitochondria-derived activator of caspase, Smac, SMACmitochondrial
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 ░C as supplied. 3 months, -20 to -70 ░C under sterile conditions after opening.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.