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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human TGF-beta 1 (Human Cell-expressed), CF
catalog :
7754-BH-005/CF
quantity :
5 ug (also 25 ug, 100 ug, 500 ug, 1000 ug)
price :
297 USD
more info or order :
citations: 53
Reference
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El Gazzar A, Kang H, Fratzl Zelman N, Webb E, Barnes A, Jovanovic M, et al. SMAD3 mutation in LDS3 causes bone fragility by impairing the TGF-β pathway and enhancing osteoclastogenesis. Bone Rep. 2022;17:101603 pubmed publisher
Werder R, Liu T, Abo K, Lindstrom Vautrin J, Villacorta Martin C, Huang J, et al. CRISPR interference interrogation of COPD GWAS genes reveals the functional significance of desmoplakin in iPSC-derived alveolar epithelial cells. Sci Adv. 2022;8:eabo6566 pubmed publisher
Cai Z, Tian S, Klein T, Tu L, Geenen L, Koudstaal T, et al. Kynurenine metabolites predict survival in pulmonary arterial hypertension: A role for IL-6/IL-6Rα. Sci Rep. 2022;12:12326 pubmed publisher
Gundersen M, Larsen K, Johnsen K, Goll R, Florholmen J, Haraldsen G. Hypo-osmotic stress induces the epithelial alarmin IL-33 in the colonic barrier of ulcerative colitis. Sci Rep. 2022;12:11550 pubmed publisher
Dai Y, Wang H, Sun R, Diao J, Ma Y, Shao M, et al. Modified Shenlingbaizhu Decoction represses the pluripotency of colorectal cancer stem cells by inhibiting TGF-β mediated EMT program. Phytomedicine. 2022;103:154234 pubmed publisher
Montefusco D, Jamil M, Maczis M, Schroeder W, Levi M, Ranjit S, et al. Sphingosine kinase 1 mediates sexual dimorphism in fibrosis in a mouse model of NASH. Mol Metab. 2022;62:101523 pubmed publisher
Bachmann J, Baumgart S, Uryga A, Bosteen M, Borghetti G, Nyberg M, et al. Fibrotic Signaling in Cardiac Fibroblasts and Vascular Smooth Muscle Cells: The Dual Roles of Fibrosis in HFpEF and CAD. Cells. 2022;11: pubmed publisher
Liu B, Sun T, Li H, Qiu S, Li Y, Zhang D. Proximal tubular RAGE mediated the renal fibrosis in UUO model mice via upregulation of autophagy. Cell Death Dis. 2022;13:399 pubmed publisher
Chapoval S, Lee M, Lemmer A, Ajayi O, Qi X, Neuwald A, et al. Identifying Function Determining Residues in Neuroimmune Semaphorin 4A. Int J Mol Sci. 2022;23: pubmed publisher
Luu V, Phan S, Jin Z. Dedifferentiation of Human Cardiac Myofibroblasts Is Independent of Activation of COX-2/PGE2 Pathway. Int J Mol Sci. 2022;23: pubmed publisher
Feng S, Peden E, Guo Q, Lee T, Li Q, Yuan Y, et al. Downregulation of the endothelial histone demethylase JMJD3 is associated with neointimal hyperplasia of arteriovenous fistulas in kidney failure. J Biol Chem. 2022;298:101816 pubmed publisher
Guo X, Sunil C, Adeyanju O, Parker A, Huang S, Ikebe M, et al. PD-L1 mediates lung fibroblast to myofibroblast transition through Smad3 and β-catenin signaling pathways. Sci Rep. 2022;12:3053 pubmed publisher
Sun L, Wang Y, Wang X, Navarro Corcuera A, Ilyas S, Jalan Sakrikar N, et al. PD-L1 promotes myofibroblastic activation of hepatic stellate cells by distinct mechanisms selective for TGF-β receptor I versus II. Cell Rep. 2022;38:110349 pubmed publisher
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Liu Y, Guo W, Guo Y, Chen X, Liu W. Bone marrow mesenchymal stem cell-derived exosomes improve renal fibrosis via regulating Smurf 2/Smad 7. Front Biosci (Landmark Ed). 2022;27:17 pubmed publisher
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product information
master code :
7754-BH/CF
SKU :
7754-BH-005/CF
product name :
Recombinant Human TGF-beta 1 (Human Cell-expressed), CF
unit size :
5 ug (also 25 ug, 100 ug, 500 ug, 1000 ug)
description :
The Recombinant Human TGF-beta 1 (Human Cell-expressed), CF from R&D Systems is derived from HEK293. The Recombinant Human TGF-beta 1 (Human Cell-expressed), CF has been validated for the following applications: Bioactivity.
target :
TGF-beta 1
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in Acetonitrile and TFA.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Human
observed molecular weight :
11 kDa, reducing conditions
theoretical molecular weight :
12.8 kDa (monomer)
gene symbol :
TGFB1
details of functionality :
Measured by its ability to inhibit the IL-4-dependent proliferation of HT-2 mouse T cells. Tsang,áM. etáal . (1995) Cytokine 7 :389. The ED50 for this effect is 0.04-0.2 ng/mL.
endotoxin note :
<0.01 EU per 1 ╡g of the protein by the LAL method.
top caption :
Graph showing dose-dependent bioactivity of Human TGF-beta 1 protein
accessionNumbers :
P01137
applications :
Bioactivity
source long :
Human embryonic kidney cell, HEK293-derived human TGF-beta 1 protein Ala279-Ser390
source short :
HEK293
USD :
297 USD
alt names :
CEDLAP, DPD1, latency-associated peptide, TGF beta, TGF beta1, TGFB, TGFB1, TGFbeta, TGFbeta 1, TGF-beta 1 protein, TGF-beta-1, transforming growth factor beta-1, transforming growth factor, beta 1
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.