Recombinant Mouse IGFBP-3 Protein, CF | R&D Systems 775-B3-025 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse IGFBP-3 Protein, CF

catalog :

775-B3-025

quantity :

25 ug

price :

432 USD

citations: 8

Reference
Green C, Span M, Rayhanna M, Perera M, Day M. Insulin-like Growth Factor Binding Protein 3 Increases Mouse Preimplantation Embryo Cleavage Rate by Activation of IGF1R and EGFR Independent of IGF1 Signalling. Cells. 2022;11: pubmed publisher
Hiroto A, Kim W, Pineda A, He Y, Lee D, Le V, et al. Stromal androgen signaling acts as tumor niches to drive prostatic basal epithelial progenitor-initiated oncogenesis. Nat Commun. 2022;13:6552 pubmed publisher
Chen S, Jing J, Yuan Y, Feng J, Han X, Wen Q, et al. Runx2+ Niche Cells Maintain Incisor Mesenchymal Tissue Homeostasis through IGF Signaling. Cell Rep. 2020;32:108007 pubmed publisher
Lui J, Garrison P, Nguyen Q, Ad M, Keembiyehetty C, Chen W, et al. EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy. Nat Commun. 2016;7:13685 pubmed publisher
Mehta H, Gao Q, Galet C, Paharkova V, Wan J, Said J, et al. IGFBP-3 is a metastasis suppression gene in prostate cancer. Cancer Res. 2011;71:5154-63 pubmed publisher
Yamada P, Mehta H, Hwang D, Roos K, Hevener A, Lee K. Evidence of a role for insulin-like growth factor binding protein (IGFBP)-3 in metabolic regulation. Endocrinology. 2010;151:5741-50 pubmed publisher
Raina K, Blouin M, Singh R, Majeed N, Deep G, Varghese L, et al. Dietary feeding of silibinin inhibits prostate tumor growth and progression in transgenic adenocarcinoma of the mouse prostate model. Cancer Res. 2007;67:11083-91 pubmed
Yakar S, Bouxsein M, Canalis E, Sun H, Glatt V, Gundberg C, et al. The ternary IGF complex influences postnatal bone acquisition and the skeletal response to intermittent parathyroid hormone. J Endocrinol. 2006;189:289-99 pubmed

product information

master code :

775-B3

SKU :

775-B3-025

product name :

Recombinant Mouse IGFBP-3 Protein, CF

unit size :

25 ug

description :

The Recombinant Mouse IGFBP-3 Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse IGFBP-3 Protein, CF has been validated for the following applications: Bioactivity.

target :

IGFBP-3

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in Acetonitrile and TFA.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Mouse

observed molecular weight :

40-50 kDa, reducing conditions

theoretical molecular weight :

29.4 kDa

gene symbol :

Igfbp3

details of functionality :

Measured by its ability to inhibit the biological activity of IGF-I or IGF-II on MCF-7 human breast cancer cells. Karey, K.P. et al . (1988) Cancer Research 48 :4083. The ED50 for this effect is 0.125-0.5 ╡g/mL in the presence of 30 ng/mL Recombinant Mouse IGF-II (Catalog # 792-MG ).

endotoxin note :

<0.01 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

CAA57271.1

applications :

Bioactivity

source long :

Mouse myeloma cell line, NS0-derived mouse IGFBP-3 protein Pro22-Gln291 with substitutions Arg250Gln, Gln259Arg, Ser260Gly, Arg271Pro

source short :

NS0

USD :

432 USD

alt names :

acid stable subunit of the 140 K IGF complex, binding protein 29, binding protein 53, growth hormone-dependent binding protein, IBP-3, IBP3BP-53, IGF-binding protein 3, IGFBP3, IGFBP-3, insulin-like growth factor binding protein 3, insulin-like growth factor-binding protein 3

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.