product summary
Loading...
company name :
R&D Systems
product type :
protein
product name :
Recombinant Human LIF Protein
catalog :
7734-LF-025
quantity :
25 ug (also 100 ug, 500 ug)
price :
344 USD
more info or order :
citations: 31
Reference
Yi S, Kim J, Kim M, Yae C, Kim K, Kim H. Development of human amniotic epithelial cell-derived extracellular vesicles as cell-free therapy for dry eye disease. Ocul Surf. 2024;34:370-380 pubmed publisher
Rafii P, Cruz P, Ettich J, Seibel C, Padrini G, Wittich C, et al. Engineered interleukin-6-derived cytokines recruit artificial receptor complexes and disclose CNTF signaling via the OSMR. J Biol Chem. 2024;300:107251 pubmed publisher
Alves J, SCHWINN M, Machleidt T, Goueli S, Cali J, Zegzouti H. Monitoring phosphorylation and acetylation of CRISPR-mediated HiBiT-tagged endogenous proteins. Sci Rep. 2024;14:2138 pubmed publisher
Jovanovic V, Weber C, Slamecka J, Ryu S, Chu P, Sen C, et al. A defined roadmap of radial glia and astrocyte differentiation from human pluripotent stem cells. Stem Cell Reports. 2023;18:1701-1720 pubmed publisher
Li J, Zhu Q, Cao J, Liu Y, Lu Y, Sun Y, et al. Cynomolgus monkey embryo model captures gastrulation and early pregnancy. Cell Stem Cell. 2023;30:362-377.e7 pubmed publisher
Xu S, Yang X, Chen Q, Liu Z, Chen Y, Yao X, et al. Leukemia inhibitory factor is a therapeutic target for renal interstitial fibrosis. EBioMedicine. 2022;86:104312 pubmed publisher
Li Z, Fang F, Long Y, Zhao Q, Wang X, Ye Z, et al. The balance between NANOG and SOX17 mediated by TET proteins regulates specification of human primordial germ cell fate. Cell Biosci. 2022;12:181 pubmed publisher
Wang S, Herriges M, Hurley K, Kotton D, Klein A. CoSpar identifies early cell fate biases from single-cell transcriptomic and lineage information. Nat Biotechnol. 2022;40:1066-1074 pubmed publisher
Lindkvist M, Zegeye M, Greneg xe5 rd M, Ljungberg L. Pleiotropic, Unique and Shared Responses Elicited by IL-6 Family Cytokines in Human Vascular Endothelial Cells. Int J Mol Sci. 2022;23: pubmed publisher
Wen Y, Liu C, Yeh H, Chen W, Jiang K, Tram V, et al. PCK1 regulates neuroendocrine differentiation in a positive feedback loop of LIF/ZBTB46 signalling in castration-resistant prostate cancer. Br J Cancer. 2022;126:778-790 pubmed publisher
Fan Y, Min Z, Alsolami S, Ma Z, Zhang E, Chen W, et al. Generation of human blastocyst-like structures from pluripotent stem cells. Cell Discov. 2021;7:81 pubmed publisher
Wang H, Si S, Jiang M, Chen L, Huang K, Yu W. Leukemia inhibitory factor is involved in the pathogenesis of NSCLC through activation of the STAT3 signaling pathway. Oncol Lett. 2021;22:663 pubmed publisher
Clements M, Holtslander L, Edwards C, Todd V, Dooyema S, Bullock K, et al. HDAC inhibitors induce LIFR expression and promote a dormancy phenotype in breast cancer. Oncogene. 2021;40:5314-5326 pubmed publisher
Yuan W, Yao Z, Veerapandian V, Yang X, Wang X, Chen D, et al. The histone demethylase KDM2B regulates human primordial germ cell-like cells specification. Int J Biol Sci. 2021;17:527-538 pubmed publisher
Lin S, Wen Y, Yeh H, Jiang K, Chen W, Mokgautsi N, et al. EGFR-upregulated LIFR promotes SUCLG2-dependent castration resistance and neuroendocrine differentiation of prostate cancer. Oncogene. 2020;39:6757-6775 pubmed publisher
Fang F, Li Z, Zhao Q, Xiong C, Ni K. Analysis of multi-lineage gene expression dynamics during primordial germ cell induction from human induced pluripotent stem cells. Stem Cell Res Ther. 2020;11:100 pubmed publisher
Li Z, Fang F, Zhao Q, Li H, Xiong C. Supplementation of vitamin C promotes early germ cell specification from human embryonic stem cells. Stem Cell Res Ther. 2019;10:324 pubmed publisher
Viswanadhapalli S, Luo Y, Sareddy G, Santhamma B, Zhou M, Li M, et al. EC359-A first-in-class small molecule inhibitor for targeting oncogenic LIFR signaling in triple negative breast cancer. Mol Cancer Ther. 2019;: pubmed publisher
Tscherner A, Brown A, Stalker L, Kao J, Dufort I, Sirard M, et al. STAT3 signaling stimulates miR-21 expression in bovine cumulus cells during in vitro oocyte maturation. Sci Rep. 2018;8:11527 pubmed publisher
Alabdi L, He M, Yang Q, Norvil A, Gowher H. The transcription factor Vezf1 represses the expression of the antiangiogenic factor Cited2 in endothelial cells. J Biol Chem. 2018;293:11109-11118 pubmed publisher
Li H, Yao J, Chang X, Wu J, Duan T, Wang K. LIFR increases the release of soluble endoglin via the upregulation of MMP14 expression in preeclampsia. Reproduction. 2018;155:297-306 pubmed publisher
Jiao S, Liu Y, Yao Y, Teng J. miR-124 promotes proliferation and differentiation of neuronal stem cells through inactivating Notch pathway. Cell Biosci. 2017;7:68 pubmed publisher
Zhang H, Sun F, Wang J, Xie L, Yang C, Pan M, et al. Combining Injectable Plasma Scaffold with Mesenchymal Stem/Stromal Cells for Repairing Infarct Cavity after Ischemic Stroke. Aging Dis. 2017;8:203-214 pubmed publisher
Armijo E, Gonzalez C, Shahnawaz M, Flores A, Davis B, Soto C. Increased susceptibility to A? toxicity in neuronal cultures derived from familial Alzheimer's disease (PSEN1-A246E) induced pluripotent stem cells. Neurosci Lett. 2017;639:74-81 pubmed publisher
Johnson R, Finger E, Olcina M, Vilalta M, Aguilera T, Miao Y, et al. Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow. Nat Cell Biol. 2016;18:1078-1089 pubmed publisher
Hong S, Choi J, Lee S, Park Y, Park K, Lee J, et al. A Novel Small-Molecule Inhibitor Targeting the IL-6 Receptor β Subunit, Glycoprotein 130. J Immunol. 2015;195:237-45 pubmed publisher
Geng Z, Li P, Tan L, Song H. Targeted Knockdown of RNA-Binding Protein TIAR for Promoting Self-Renewal and Attenuating Differentiation of Mouse Embryonic Stem Cells. Stem Cells Int. 2015;2015:657325 pubmed publisher
Kwofie K, Scott M, Rodrigues R, Guerette J, Radford K, Nair P, et al. Regulation of IL-17A responses in human airway smooth muscle cells by Oncostatin M. Respir Res. 2015;16:14 pubmed publisher
Kondo T, Funayama M, Tsukita K, Hotta A, Yasuda A, Nori S, et al. Focal transplantation of human iPSC-derived glial-rich neural progenitors improves lifespan of ALS mice. Stem Cell Reports. 2014;3:242-9 pubmed publisher
Lapeire L, Hendrix A, Lambein K, Van Bockstal M, Braems G, Van Den Broecke R, et al. Cancer-associated adipose tissue promotes breast cancer progression by paracrine oncostatin M and Jak/STAT3 signaling. Cancer Res. 2014;74:6806-19 pubmed publisher
Wagener E, Aurich M, Aparicio Siegmund S, Floss D, Garbers C, Breusing K, et al. The amino acid exchange R28E in ciliary neurotrophic factor (CNTF) abrogates interleukin-6 receptor-dependent but retains CNTF receptor-dependent signaling via glycoprotein 130 (gp130)/leukemia inhibitory factor receptor (LIFR). J Biol Chem. 2014;289:18442-50 pubmed publisher
product information
brand :
R&D Systems
master code :
7734-LF
SKU :
7734-LF-025
product name :
Recombinant Human LIF Protein
unit size :
25 ug (also 100 ug, 500 ug)
seo description :
The Recombinant Human LIF Protein from R&D Systems is derived from E. coli. The Recombinant Human LIF Protein has been validated for the following applications: Bioactivity.
target :
LIF
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with BSA as a carrier protein.
conjugate :
Unconjugated
dilution :
Bioactivity
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
species :
Human
observed molecular weight :
19 kDa, reducing conditions
theoretical molecular weight :
19.6 kDa
gene symbol :
LIF
details of functionality :
Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. Kitamura, T. et al . (1989) J. Cell Physiol. 140 :323. The ED50 for this effect is 0.02-0.12 ng/mL.
endotoxin note :
<0.01 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
P15018
applications :
Bioactivity
source :
E. coli-derived Recombinant Human LIF Protein
USD :
344 USD
alt names :
CDF, D factor, DIA, differentiation inhibitory activity, differentiation stimulating factor, Differentiation-stimulating factor, Emfilermin, HILDA, HILDAcholinergic differentiation factor, leukemia inhibitory factor, leukemia inhibitory factor (cholinergic differentiation factor), Melanoma-derived LPL inhibitor, MLPLI
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.