Recombinant Mouse IL-1 RI Fc Chimera Protein, CF | R&D Systems 771-MR-100 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse IL-1 RI Fc Chimera Protein, CF

catalog :

771-MR-100

quantity :

100 ug

price :

540 USD

more info or order :

R&D Systems product webpage

citations: 3

Reference
Grayson B, Levasseur P, Williams S, Smith M, Marks D, Grove K. Changes in melanocortin expression and inflammatory pathways in fetal offspring of nonhuman primates fed a high-fat diet. Endocrinology. 2010;151:1622-32 pubmed publisher
Chackerian A, Oldham E, Murphy E, Schmitz J, Pflanz S, Kastelein R. IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex. J Immunol. 2007;179:2551-5 pubmed
O Connor J, Sherry C, Guest C, Freund G. Type 2 diabetes impairs insulin receptor substrate-2-mediated phosphatidylinositol 3-kinase activity in primary macrophages to induce a state of cytokine resistance to IL-4 in association with overexpression of suppressor of cytokine signaling-3. J Immunol. 2007;178:6886-93 pubmed

product information

master code :

771-MR

SKU :

771-MR-100

product name :

Recombinant Mouse IL-1 RI Fc Chimera Protein, CF

unit size :

100 ug

description :

The Recombinant Mouse IL-1 RI Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse IL-1 RI Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

IL-1 RI

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Mouse

observed molecular weight :

95-110 kDa, reducing conditions

theoretical molecular weight :

63.8 kDa (monomer)

gene symbol :

Il1r1

details of functionality :

Measured by its ability to inhibit IL-1 alpha -dependent proliferation in D10.G4.1 mouse helper T cells. Symons, J.A. etáal . (1987) in Lymphokines and Interferons, a Practical Approach. Clemens, M.J. etáal . (eds): IRL Press. 272. Approximately 0.005-0.015á╡g/mL of IL-1ásRI/Fc Chimera will inhibit 50% of the biological response due to 50ápg/mL of rmIL-1a.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P13504

applications :

Bioactivity

source long :

Mouse myeloma cell line, NS0-derived mouse IL-1 RI protein Mouse IL-1 RI (Leu20 - Lys338) Accession # P13504 IEGRMD Human IgG1 (Pro100 - Lys330) N-terminus C-terminus

source short :

NS0

USD :

540 USD

alt names :

CD121 antigen-like family member A, CD121a, CD121a antigen, IL1R, IL1R1, IL1RI, IL-1RI, IL1RT1, IL-1RT1, IL-1RT-1, Interleukin 1 Receptor 1, interleukin 1 receptor, type I, interleukin receptor 1, interleukin-1 receptor type 1, p80

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage