Recombinant Mouse ALK-1 Fc Chimera Protein, CF | R&D Systems 770-MA-100 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse ALK-1 Fc Chimera Protein, CF

catalog :

770-MA-100

quantity :

100 ug

price :

468 USD

more info or order :

R&D Systems product webpage

citations: 5

Reference
Verma R, Jaiswal H, Chauhan K, Kaushik M, Tailor P. Cutting Edge: ACVRL1 Signaling Augments CD8?+ Dendritic Cell Development. J Immunol. 2016;197:1029-34 pubmed publisher
Chen J, Liu H, Liu J, Qi J, Wei B, Yang J, et al. H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs. Nat Genet. 2013;45:34-42 pubmed publisher
Ricard N, Ciais D, Levet S, Subileau M, Mallet C, Zimmers T, et al. BMP9 and BMP10 are critical for postnatal retinal vascular remodeling. Blood. 2012;119:6162-71 pubmed publisher
Lin L, Valore E, Nemeth E, Goodnough J, Gabayan V, Ganz T. Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4. Blood. 2007;110:2182-9 pubmed
Lopez Coviella I, Mellott T, Kovacheva V, Berse B, Slack B, Zemelko V, et al. Developmental pattern of expression of BMP receptors and Smads and activation of Smad1 and Smad5 by BMP9 in mouse basal forebrain. Brain Res. 2006;1088:49-56 pubmed

product information

master code :

770-MA

SKU :

770-MA-100

product name :

Recombinant Mouse ALK-1 Fc Chimera Protein, CF

unit size :

100 ug

description :

The Recombinant Mouse ALK-1 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse ALK-1 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

ALK-1

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Mouse

observed molecular weight :

50-55 kDa, reducing conditions

theoretical molecular weight :

37.7 kDa (monomer)

gene symbol :

Acvrl1

details of functionality :

Measured by its ability to inhibit BMP-9-induced alkaline phosphatase production by ATDC5 mouse chondrogenic cells. David, L. et al . (2007) Blood 109 :1953. The ED50 for this effect is 20-80 ng/mL in the presence of 2 ng/mL of rhBMP-9.

endotoxin note :

<0.1 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q61288

applications :

Bioactivity

source long :

Mouse myeloma cell line, NS0-derived mouse ALK-1 protein Mouse ALK-1 (Asp23 - Pro119) Accession # Q61288 IEGRMD Human IgG1 (Pro100 - Lys330) N-terminus C-terminus

source short :

NS0

USD :

468 USD

alt names :

activin A receptor type II-like 1, activin A receptor, type II-like kinase 1, Activin receptor-like kinase 1, ACVRL1, ACVRLK1ORW2, ALK1, ALK-1, ALK1TGF-B superfamily receptor type I, EC 2.7.11, HHT, HHT2EC 2.7.11.30, serine/threonine-protein kinase receptor R3, SKR3, TSR-I

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage