Recombinant Human FGFR3 (IIIc) Fc Chimera Protein, CF | R&D Systems 766-FR product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human FGFR3 (IIIc) Fc Chimera Protein, CF

catalog :

766-FR

quantity :

50 ug

price :

339 USD

citations: 3

Reference
Yin Y, Ren X, Smith C, Guo Q, Malabunga M, Guernah I, et al. Inhibition of fibroblast growth factor receptor 3-dependent lung adenocarcinoma with a human monoclonal antibody. Dis Model Mech. 2016;9:563-71 pubmed publisher
Chan W, Howe K, Clegg J, Guimond S, Price D, Turnbull J, et al. 2-O Heparan Sulfate Sulfation by Hs2st Is Required for Erk/Mapk Signalling Activation at the Mid-Gestational Mouse Telencephalic Midline. PLoS ONE. 2015;10:e0130147 pubmed publisher
Martinez Torrecuadrada J, Cifuentes G, López Serra P, Saenz P, Martinez A, Casal J. Targeting the extracellular domain of fibroblast growth factor receptor 3 with human single-chain Fv antibodies inhibits bladder carcinoma cell line proliferation. Clin Cancer Res. 2005;11:6280-90 pubmed

product information

brand :

R&D Systems

master code :

766-FR

SKU :

766-FR-050

product name :

Recombinant Human FGFR3 (IIIc) Fc Chimera Protein, CF

description :

The Recombinant Human FGFR3 (IIIc) Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human FGFR3 (IIIc) Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

FGFR3

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

95-105 kDa, reducing conditions

theoretical molecular weight :

64.7 kDa (monomer)

gene symbol :

FGFR3

details of functionality :

Measured by its ability to inhibit FGF acidic-dependent proliferation of NR6R-3T3 mouse fibroblast cells. The ED50 for this effect is 1-3 ng/mL.

endotoxin note :

<0.1 EU per 1 µg of the protein by the LAL method.

catalog number base :

766-FR

accessionNumbers :

P22607

applications :

Bioactivity

source :

Mouse myeloma cell line, NS0-derived human FGF R3 protein Human FGF R3 (IIIc) (Glu23-Gly375) Accession # P22607 IEGRMD Human IgG1 (Pro100-Lys330) N-terminus C-terminus

2020 USD :

339

2021 USD :

339 USD

alt names :

CD333, CEK, EC 2.7.10, FGF R3, fibroblast growth factor receptor 3, HSFGFR3EX, JTK4, JTK4thanatophoric dwarfism

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.