Recombinant Human IL-37b/IL-1F7b Protein, CF | R&D Systems 7585-IL-025/CF product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human IL-37b/IL-1F7b Protein, CF

catalog :

7585-IL-025/CF

quantity :

25 ug

price :

400 USD

more info or order :

R&D Systems product webpage

citations: 9

Reference
Kolotilin I. Plant-produced recombinant cytokines IL-37b and IL-38 modulate inflammatory response from stimulated human PBMCs. Sci Rep. 2022;12:19450 pubmed publisher
Ueno Shuto K, Kamei S, Hayashi M, Fukuyama A, Uchida Y, Tokutomi N, et al. A Splice Switch in SIGIRR Causes a Defect of IL-37-Dependent Anti-Inflammatory Activity in Cystic Fibrosis Airway Epithelial Cells. Int J Mol Sci. 2022;23: pubmed publisher
Jia C, Zhuge Y, Zhang S, Ni C, Wang L, Wu R, et al. IL-37b alleviates endothelial cell apoptosis and inflammation in Kawasaki disease through IL-1R8 pathway. Cell Death Dis. 2021;12:575 pubmed publisher
Tsilioni I, Pantazopoulos H, Conti P, Leeman S, Theoharides T. IL-38 inhibits microglial inflammatory mediators and is decreased in amygdala of children with autism spectrum disorder. Proc Natl Acad Sci U S A. 2020;117:16475-16480 pubmed publisher
Tsilioni I, Patel A, Pantazopoulos H, Berretta S, Conti P, Leeman S, et al. IL-37 is increased in brains of children with autism spectrum disorder and inhibits human microglia stimulated by neurotensin. Proc Natl Acad Sci U S A. 2019;116:21659-21665 pubmed publisher
Wang D, Dong N, Wu Y, Zhu X, Wang C, Yao Y. Interleukin-37 Enhances the Suppressive Activity of Naturally Occurring CD4+CD25+ Regulatory T Cells. Sci Rep. 2016;6:38955 pubmed publisher
Cavalli G, Koenders M, Kalabokis V, Kim J, Tan A, Garlanda C, et al. Treating experimental arthritis with the innate immune inhibitor interleukin-37 reduces joint and systemic inflammation. Rheumatology (Oxford). 2016;55:2220-2229 pubmed
Lin L, Wang J, Liu D, Liu S, Xu H, Ji N, et al. Interleukin-37 expression and its potential role in oral leukoplakia and oral squamous cell carcinoma. Sci Rep. 2016;6:26757 pubmed publisher
Wang W, Zhao D, Zhou Y, Hu X, Sun Z, Yu G, et al. Transfer of the IL-37b gene elicits anti-tumor responses in mice bearing 4T1 breast cancer. Acta Pharmacol Sin. 2015;36:528-34 pubmed publisher

product information

brand :

R&D Systems

master code :

7585-IL/CF

SKU :

7585-IL-025/CF

product name :

Recombinant Human IL-37b/IL-1F7b Protein, CF

unit size :

25 ug

seo description :

The Recombinant Human IL-37b/IL-1F7b Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human IL-37b/IL-1F7b Protein, CF has been validated for the following applications: Bioactivity.

target :

IL-37b/IL-1F7b

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS and DTT.

conjugate :

Unconjugated

dilution :

Bioactivity

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

25 kDa, reducing conditions

theoretical molecular weight :

19.4 kDa

gene symbol :

IL37

details of functionality :

Measured by its ability to enhance IL-18 BP inhibition of IL-18-induced IFN-gamma release by KG-1 human acute myelogenous leukemia cells. Bufler, P. et al . (2002) PNAS 99 :13723. The ED50 for this effect is 2.5-12.5 ╡g/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q9NZH6

applications :

Bioactivity

source :

E. coli-derived Recombinant Human IL-37b/IL-1F7b Protein, CF

extended description :

rh IL-37 Isoform a (Catalog # 1975-IL) is also available!

USD :

400 USD

product details :

rh IL-37 Isoform a (Catalog # 1975-IL) is also available!

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage