product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse Chordin Protein
catalog :
758-CN-050
quantity :
50 ug
price :
456 USD
more info or order :
R&D Systems product webpage
citations: 11
Reference
Wang C, Gong S, Guan W, Wang J, Gao T, Wang Y, et al. Hippocampal overexpression of chordin protects against the chronic social defeat stress-induced depressive-like effects in mice. Brain Res Bull. 2020;158:31-39 pubmed publisher
Sieron L, Lesiak M, Schisler I, Drzazga Z, Fertala A, Sieron A. Functional and structural studies of tolloid-like 1 mutants associated with atrial-septal defect 6. Biosci Rep. 2019;39: pubmed publisher
Zakin L, Chang E, Plouhinec J, De Robertis E. Crossveinless-2 is required for the relocalization of Chordin protein within the vertebral field in mouse embryos. Dev Biol. 2010;347:204-15 pubmed publisher
Jablonska B, Aguirre A, Raymond M, Szabo G, Kitabatake Y, Sailor K, et al. Chordin-induced lineage plasticity of adult SVZ neuroblasts after demyelination. Nat Neurosci. 2010;13:541-550 pubmed publisher
Hayashi K, Surani M. Self-renewing epiblast stem cells exhibit continual delineation of germ cells with epigenetic reprogramming in vitro. Development. 2009;136:3549-56 pubmed publisher
Kelley R, Ren R, Pi X, Wu Y, Moreno I, Willis M, et al. A concentration-dependent endocytic trap and sink mechanism converts Bmper from an activator to an inhibitor of Bmp signaling. J Cell Biol. 2009;184:597-609 pubmed publisher
Ambrosio A, Taelman V, Lee H, Metzinger C, Coffinier C, De Robertis E. Crossveinless-2 Is a BMP feedback inhibitor that binds Chordin/BMP to regulate Xenopus embryonic patterning. Dev Cell. 2008;15:248-60 pubmed publisher
Boswell B, Lein P, Musil L. Cross-talk between fibroblast growth factor and bone morphogenetic proteins regulates gap junction-mediated intercellular communication in lens cells. Mol Biol Cell. 2008;19:2631-41 pubmed publisher
McLean A, D Amour K, Jones K, Krishnamoorthy M, Kulik M, Reynolds D, et al. Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed. Stem Cells. 2007;25:29-38 pubmed
Maeshima A, Vaughn D, Choi Y, Nigam S. Activin A is an endogenous inhibitor of ureteric bud outgrowth from the Wolffian duct. Dev Biol. 2006;295:473-85 pubmed
Reversade B, De Robertis E. Regulation of ADMP and BMP2/4/7 at opposite embryonic poles generates a self-regulating morphogenetic field. Cell. 2005;123:1147-60 pubmed
product information
brand :
R&D Systems
master code :
758-CN
SKU :
758-CN-050
product name :
Recombinant Mouse Chordin Protein
unit size :
50 ug
seo description :
The Recombinant Mouse Chordin Protein from R&D Systems is derived from NS0. The Recombinant Mouse Chordin Protein has been validated for the following applications: Bioactivity.
target :
Chordin
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with BSA as a carrier protein.
conjugate :
Unconjugated
dilution :
Bioactivity
purity :
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Mouse
observed molecular weight :
100-115 kDa, reducing conditions
theoretical molecular weight :
101.5 kDa
gene symbol :
Chrd
details of functionality :
Measured by its ability to inhibit BMP-4-induced alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The ED50 for this effect is 2-6 ╡g/mL in the presence of 30 ng/mL of Recombinant Human BMP-4 (Catalog # 314-BP ) and 1 ╡g/mL of recombinant mouse TSG.
endotoxin note :
<1.0 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
Q9Z0E2
applications :
Bioactivity
source :
NS0-derived Recombinant Mouse Chordin Protein
USD :
456 USD
alt names :
CHRD, MGC133038, Sog
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.