Recombinant Human VEGF-C (Cys156Ser) Protein, CF | R&D Systems 752-VC-025/CF product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human VEGF-C (Cys156Ser) Protein, CF

catalog :

752-VC-025/CF

quantity :

25 ug

price :

388 USD

more info or order :

R&D Systems product webpage

citations: 18

Reference
Dutta S, Polavaram N, Islam R, Bhattacharya S, Bodas S, Mayr T, et al. Neuropilin-2 regulates androgen-receptor transcriptional activity in advanced prostate cancer. Oncogene. 2022;41:3747-3760 pubmed publisher
Chakraborty A, Upadhya R, Usman T, Shetty A, Rutkowski J. Chronic VEGFR-3 signaling preserves dendritic arborization and sensitization under stress. Brain Behav Immun. 2021;98:219-233 pubmed publisher
Shimizu Y, Polavarapu R, Eskla K, Pantner Y, Nicholson C, Ishii M, et al. Impact of Lymphangiogenesis on Cardiac Remodeling After Ischemia and Reperfusion Injury. J Am Heart Assoc. 2018;7:e009565 pubmed publisher
Vieira J, Norman S, Villa del Campo C, Cahill T, Barnette D, Gunadasa Rohling M, et al. The cardiac lymphatic system stimulates resolution of inflammation following myocardial infarction. J Clin Invest. 2018;128:3402-3412 pubmed publisher
Wen Y, Yang J, Wang X, Yao Z. Induced dural lymphangiogenesis facilities soluble amyloid-beta clearance from brain in a transgenic mouse model of Alzheimer's disease. Neural Regen Res. 2018;13:709-716 pubmed publisher
Rauniyar K, Jha S, Jeltsch M. Biology of Vascular Endothelial Growth Factor C in the Morphogenesis of Lymphatic Vessels. Front Bioeng Biotechnol. 2018;6:7 pubmed publisher
Louveau A, Smirnov I, Keyes T, Eccles J, Rouhani S, Peske J, et al. Structural and functional features of central nervous system lymphatic vessels. Nature. 2015;523:337-41 pubmed publisher
Heishi T, Hosaka T, Suzuki Y, Miyashita H, Oike Y, Takahashi T, et al. Endogenous angiogenesis inhibitor vasohibin1 exhibits broad-spectrum antilymphangiogenic activity and suppresses lymph node metastasis. Am J Pathol. 2010;176:1950-8 pubmed publisher
Chien M, Ku C, Johansson G, Chen M, Hsiao M, Su J, et al. Vascular endothelial growth factor-C (VEGF-C) promotes angiogenesis by induction of COX-2 in leukemic cells via the VEGF-R3/JNK/AP-1 pathway. Carcinogenesis. 2009;30:2005-13 pubmed publisher
Kajiya K, Sawane M, Huggenberger R, Detmar M. Activation of the VEGFR-3 pathway by VEGF-C attenuates UVB-induced edema formation and skin inflammation by promoting lymphangiogenesis. J Invest Dermatol. 2009;129:1292-8 pubmed publisher
Shin J, Huggenberger R, Detmar M. Transcriptional profiling of VEGF-A and VEGF-C target genes in lymphatic endothelium reveals endothelial-specific molecule-1 as a novel mediator of lymphangiogenesis. Blood. 2008;112:2318-26 pubmed publisher
Uzarski J, Drelles M, Gibbs S, Ongstad E, Goral J, McKeown K, et al. The resolution of lymphedema by interstitial flow in the mouse tail skin. Am J Physiol Heart Circ Physiol. 2008;294:H1326-34 pubmed publisher
Kilic N, Oliveira Ferrer L, Neshat Vahid S, Irmak S, Obst Pernberg K, Wurmbach J, et al. Lymphatic reprogramming of microvascular endothelial cells by CEA-related cell adhesion molecule-1 via interaction with VEGFR-3 and Prox1. Blood. 2007;110:4223-33 pubmed
Huber S, Bruns C, Schmid G, Hermann P, Conrad C, Niess H, et al. Inhibition of the mammalian target of rapamycin impedes lymphangiogenesis. Kidney Int. 2007;71:771-7 pubmed
Goldman J, Conley K, Raehl A, Bondy D, Pytowski B, Swartz M, et al. Regulation of lymphatic capillary regeneration by interstitial flow in skin. Am J Physiol Heart Circ Physiol. 2007;292:H2176-83 pubmed
Le Bras B, Barallobre M, Homman Ludiye J, Ny A, Wyns S, Tammela T, et al. VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain. Nat Neurosci. 2006;9:340-8 pubmed
Shin J, Min M, Larrieu Lahargue F, Canron X, Kunstfeld R, Nguyen L, et al. Prox1 promotes lineage-specific expression of fibroblast growth factor (FGF) receptor-3 in lymphatic endothelium: a role for FGF signaling in lymphangiogenesis. Mol Biol Cell. 2006;17:576-84 pubmed
Hamaguchi I, Morisada T, Azuma M, Murakami K, Kuramitsu M, Mizukami T, et al. Loss of Tie2 receptor compromises embryonic stem cell-derived endothelial but not hematopoietic cell survival. Blood. 2006;107:1207-13 pubmed

product information

brand :

R&D Systems

master code :

752-VC/CF

SKU :

752-VC-025/CF

product name :

Recombinant Human VEGF-C (Cys156Ser) Protein, CF

description :

The Recombinant Human VEGF-C (Cys156Ser) Protein, CF from R&D Systems is derived from NS0. The Recombinant Human VEGF-C (Cys156Ser) Protein, CF has been validated for the following applications: Bioactivity, Binding Activity.

target :

VEGF-C

category :

Proteins and Enzymes

unit sizes :

25 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

22-24 kDa, reducing conditions

theoretical molecular weight :

15.4 kDa

gene symbol :

VEGFC

details of functionality :

Measured in a cell proliferation assay using HMVEC human microvascular endothelial cells. Marconcini, L. et al . (1999) Proc. Natl. Acad. Sci. USA 96 :9671. The ED50 for this effect is 1-5 µg/mL. Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human VEGF R3/Flt-4 Fc Chimera (Catalog # 349-F4 ) at 5 µg/mL (100 µL/well) can bind Recombinant Human VEGF-C (Cys156Ser) with an apparent Kd 40 nM.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

Q6FH59

applications :

Bioactivity, Binding Activity

source :

NS0-derived Recombinant Human VEGF-C (Cys156Ser) Protein, CF

USD :

388 USD

alt names :

Flt4 ligand, Flt4-L, vascular endothelial growth factor C, Vascular endothelial growth factor-related protein, VEGFC, VEGF-C, VRPFLT4 ligand DHM

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage