product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Semaphorin 4D Fc Chimera Protein, CF
catalog :
7470-S4-050
quantity :
50 ug
price :
443 USD
more info or order :
R&D Systems product webpage
citations: 4
Reference
Adel S, Clarke V, Evans Strong A, Maguire J, Paradis S. Semaphorin 4D induced inhibitory synaptogenesis decreases epileptiform activity and alters progression to Status Epilepticus in mice. Epilepsy Res. 2023;193:107156 pubmed publisher
Vogler M, Oleksy A, Schulze S, Fedorova M, Kojonazarov B, Nijjar S, et al. An antagonistic monoclonal anti-Plexin-B1 antibody exerts therapeutic effects in mouse models of postmenopausal osteoporosis and multiple sclerosis. J Biol Chem. 2022;298:102265 pubmed publisher
Huang J, Wu S, Cao S, Zhu X, Zhang S. Neutrophil-Derived Semaphorin 4D Induces Inflammatory Cytokine Production of Endothelial Cells via Different Plexin Receptors in Kawasaki Disease. Biomed Res Int. 2020;2020:6663291 pubmed publisher
Stromecki M, Tatari N, Morrison L, Kaur R, Zagozewski J, Palidwor G, et al. Characterization of a novel OTX2-driven stem cell program in Group 3 and Group 4 medulloblastoma. Mol Oncol. 2018;12:495-513 pubmed publisher
product information
brand :
R&D Systems, a Bio-Techne Brand
catalog number base :
7470-S4
SKU :
7470-S4-050
product name :
Recombinant Human Semaphorin 4D Fc Chimera Protein, CF
Description :
The Recombinant Human Semaphorin 4D Fc Chimera Protein, CF from R&D Systems is derived from CHO. The Recombinant Human Semaphorin 4D Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.
target :
Semaphorin 4D/CD100
category :
Proteins and Enzymes
unit size :
50 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose.
conjugate :
Unconjugated
purity :
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Human
observed molecular weight :
110-135 kDa, reducing conditions
theoretical molecular weight :
105.8 kDa (monomer)
gene symbol :
SEMA4D
details of functionality :
Measured by its ability to inhibit survival of SK-OV-3 human ovarian carcinoma cells. The ED50 for this effect is typically 0.4-2 µg/mL. Measured by its binding ability in a functional ELISA. When Recombinant Human Plexin B2 (Catalog # 5329-PB ) is coated at 5 µg/mL, Recombinant Human Semaphorin 4D/CD100 Fc Chimera binds with an apparent Kd 4 nM.
endotoxin note :
<0.01 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
Q92854
applications :
Bioactivity
source :
CHO-derived Recombinant Human Semaphorin 4D Fc Chimera Protein
USD :
443 USD
alt names :
A8, BB18, CD100, CD100 antigen, CD100M-sema-G, coll-4, FLJ33485, FLJ34282, FLJ39737, FLJ46484, immunoglobulin domain (Ig), transmembrane domain (TM) and shortcytoplasmic domain, 4D, MGC169138, MGC169141, M-sema-G, sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and shortcytoplasmic domain, (semaphorin) 4D, SEMA4D, SEMAJ, semaphorin-4D
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.