Recombinant Mouse IL-27 p28/IL-30 Protein | R&D Systems 7430-ML-010 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse IL-27 p28/IL-30 Protein

catalog :

7430-ML-010

quantity :

10 ug

price :

432 USD

more info or order :

R&D Systems product webpage

citations: 4

Reference
Kim D, Kim S, Kang M, Yin Z, Min B. Cell type specific IL-27p28 (IL-30) deletion in mice uncovers an unexpected regulatory function of IL-30 in autoimmune inflammation. Sci Rep. 2023;13:1812 pubmed publisher
Sorrentino C, D Antonio L, Ciummo S, Fieni C, Landuzzi L, Ruzzi F, et al. CRISPR/Cas9-mediated deletion of Interleukin-30 suppresses IGF1 and CXCL5 and boosts SOCS3 reducing prostate cancer growth and mortality. J Hematol Oncol. 2022;15:145 pubmed publisher
Hooper K, Kong W, Ganea D. Prostaglandin E2 inhibits Tr1 cell differentiation through suppression of c-Maf. PLoS ONE. 2017;12:e0179184 pubmed publisher
Dietrich C, Candon S, Ruemmele F, Devergne O. A soluble form of IL-27R? is a natural IL-27 antagonist. J Immunol. 2014;192:5382-9 pubmed publisher

product information

master code :

7430-ML

SKU :

7430-ML-010

product name :

Recombinant Mouse IL-27 p28/IL-30 Protein

unit size :

10 ug

description :

The Recombinant Mouse IL-27 p28/IL-30 Protein from R&D Systems is derived from NS0. The Recombinant Mouse IL-27 p28/IL-30 Protein has been validated for the following applications: Bioactivity.

target :

IL-27 p28/IL-30

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in HEPES, NaCl and CHAPS with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Mouse

observed molecular weight :

25-35 kDa, reducing conditions

theoretical molecular weight :

24.9 kDa

gene symbol :

Il27

details of functionality :

Measured by its ability to induce CXCL10/IP-10 secretion by THP-1 human acute monocytic leukemia cells. The ED50 for this effect 35 ng/mL.

endotoxin note :

<0.01 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q8K3I6

applications :

Bioactivity

source long :

Mouse myeloma cell line, NS0-derived mouse IL-27 p28/IL-30 protein Phe29-Ser234, with a C-terminal 10-His tag

source short :

NS0

USD :

432 USD

alt names :

IL27 p28, IL27;IL-27;IL27A;IL-27A;IL27p28;IL-27p28;IL30;p28, IL-30

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage