Recombinant Mouse VEGFR3/Flt-4 Fc Chimera Protein, CF | R&D Systems 743-R3-100 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse VEGFR3/Flt-4 Fc Chimera Protein, CF

catalog :

743-R3-100

quantity :

100 ug

price :

491 USD

citations: 9

Reference
Martínez Corral I, Zhang Y, Petkova M, Orts xe4 ter H, Sj xf6 berg S, Castillo S, et al. Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation. Nat Commun. 2020;11:2869 pubmed publisher
Louveau A, Smirnov I, Keyes T, Eccles J, Rouhani S, Peske J, et al. Structural and functional features of central nervous system lymphatic vessels. Nature. 2015;523:337-41 pubmed publisher
Decio A, Taraboletti G, Patton V, Alzani R, Perego P, Fruscio R, et al. Vascular endothelial growth factor c promotes ovarian carcinoma progression through paracrine and autocrine mechanisms. Am J Pathol. 2014;184:1050-1061 pubmed publisher
Conrady C, Zheng M, Stone D, Carr D. CD8+ T cells suppress viral replication in the cornea but contribute to VEGF-C-induced lymphatic vessel genesis. J Immunol. 2012;189:425-32 pubmed publisher
Benedito R, Rocha S, Woeste M, Zamykal M, Radtke F, Casanovas O, et al. Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling. Nature. 2012;484:110-4 pubmed publisher
Wuest T, Carr D. VEGF-A expression by HSV-1-infected cells drives corneal lymphangiogenesis. J Exp Med. 2010;207:101-15 pubmed publisher
Halin C, Tobler N, Vigl B, Brown L, Detmar M. VEGF-A produced by chronically inflamed tissue induces lymphangiogenesis in draining lymph nodes. Blood. 2007;110:3158-67 pubmed
Cursiefen C, Chen L, Saint Geniez M, Hamrah P, Jin Y, Rashid S, et al. Nonvascular VEGF receptor 3 expression by corneal epithelium maintains avascularity and vision. Proc Natl Acad Sci U S A. 2006;103:11405-10 pubmed
Cao R, Björndahl M, Gallego M, Chen S, Religa P, Hansen A, et al. Hepatocyte growth factor is a lymphangiogenic factor with an indirect mechanism of action. Blood. 2006;107:3531-6 pubmed

product information

master code :

743-R3

SKU :

743-R3-100

product name :

Recombinant Mouse VEGFR3/Flt-4 Fc Chimera Protein, CF

unit size :

100 ug

description :

The Recombinant Mouse VEGFR3/Flt-4 Fc Chimera Protein, CF from R&D Systems is derived from Sf 21 (baculovirus). The Recombinant Mouse VEGFR3/Flt-4 Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.

target :

VEGFR3/Flt-4

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Mouse

observed molecular weight :

123 kDa with two additional minor bands at 73 kDa and 60 kDa, reducing conditions

theoretical molecular weight :

112 kDa (monomer)

gene symbol :

Flt4

details of functionality :

Measured by its binding ability in a functional ELISA. Immobilized Recombinant Mouse VEGFR3/Flt-4 Fc Chimera (Catalog # 743-R3) at 5 ╡g/mL (100 ╡L/well) can bind Recombinant Mouse VEGF-D (Catalog # 469-VD) with an apparent Kd 50 nM.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P35917

applications :

Binding Activity

source long :

Spodoptera frugiperda , Sf 21 (baculovirus)-derived mouse VEGFR3/Flt-4 protein Met Mouse VEGFR3 (Tyr25-Asp770) Accession # P35917 IEGRDID Human IgG1 (Pro100-Lys330) 6-His tag N-terminus C-terminus

source short :

Sf 21 (baculovirus)

USD :

491 USD

alt names :

EC 2.7.10, EC 2.7.10.1, Flt-4, FLT4, fms-related tyrosine kinase 4, LMPH1A, PCLFLT41, soluble VEGFR3 variant 1, soluble VEGFR3 variant 2, soluble VEGFR3 variant 3, Tyrosine-protein kinase receptor FLT4, vascular endothelial growth factor receptor 3, VEGF R3, VEGFR-3, VEGFR3Fms-like tyrosine kinase 4

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.