Recombinant Human Glucosylceramidase/GBA Protein, CF | R&D Systems 7410-GHB product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Glucosylceramidase/GBA Protein, CF

catalog :

7410-GHB

quantity :

20 ug (also 1 mg)

price :

349 USD

citations: 6

Reference
Do M, Levy D, Brown A, Marriott G, Lu B. Targeted delivery of lysosomal enzymes to the endocytic compartment in human cells using engineered extracellular vesicles. Sci Rep. 2019;9:17274 pubmed publisher
Li H, Ham A, Ma T, Kuo S, Kanter E, Kim D, et al. Mitochondrial dysfunction and mitophagy defect triggered by heterozygous GBA mutations. Autophagy. 2019;15:113-130 pubmed publisher
Yun S, Kim D, Kim S, Kim S, Karuppagounder S, Kwon S, et al. α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism. Mol Neurodegener. 2018;13:1 pubmed publisher
Ashmus R, Shen D, Vocadlo D. Fluorescence-Quenched Substrates for Quantitative Live Cell Imaging of Glucocerebrosidase Activity. Methods Enzymol. 2018;598:199-215 pubmed publisher
Choi S, Kim D, Kam T, Yun S, Kim S, Park H, et al. Lysosomal Enzyme Glucocerebrosidase Protects against AÎ²1-42 Oligomer-Induced Neurotoxicity. PLoS ONE. 2015;10:e0143854 pubmed publisher
Berger Z, Perkins S, Ambroise C, Oborski C, Calabrese M, Noell S, et al. Tool compounds robustly increase turnover of an artificial substrate by glucocerebrosidase in human brain lysates. PLoS ONE. 2015;10:e0119141 pubmed publisher

product information

brand :

R&D Systems

master code :

7410-GHB

SKU :

7410-GHB-020

product name :

Recombinant Human Glucosylceramidase/GBA Protein, CF

description :

The Recombinant Human Glucosylceramidase/GBA Protein, CF from R&D Systems is derived from CHO. The Recombinant Human Glucosylceramidase/GBA Protein, CF has been validated for the following applications: Enzyme Activity.

target :

Glucosylceramidase / GBA

category :

Proteins and Enzymes

unit size :

20 ug (also 1 mg)

buffer :

Supplied as a 0.2 µm filtered solution in Sodium Citrate.

conjugate :

Unconjugated

main entrez gene id :

2629

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

60-75 kDa, reducing conditions

theoretical molecular weight :

56 kDa

details of functionality :

Measured by its ability to hydrolyze 4-methylumbelliferyl-beta-D-glucopyranoside. The specific activity is 200 pmol/min/µg, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

catalog number base :

7410-GHB

accessionNumbers :

P04062.3

applications :

Enzyme Activity

source :

The Recombinant Human Glucosylceramidase / GBA Protein, CF from R&D Systems is derived from CHO. The Recombinant Human Glucosylceramidase / GBA Protein, CF has been validated for the following applications: Enzyme Activity.

USD :

349 USD

alt names :

Acid beta-glucosidase, alglucerase, Beta-glucocerebrosidase, D-glucosyl-N-acylsphingosine glucohydrolase, EC 3.2.1.45, GBA, GBA1, GC, GCB, GLUC, glucosidase, beta, acid, glucosidase, beta; acid (includes glucosylceramidase), glucosylceramidase, imiglucerase, lysosomal glucocerebrosidase

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after opening.