Recombinant Mouse B7-1/CD80 Fc Chimera His-tag Protein, CF | R&D Systems 740-B1-100 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse B7-1/CD80 Fc Chimera His-tag Protein, CF

catalog :

740-B1-100

quantity :

100 ug (also 1 mg)

price :

423 USD

more info or order :

R&D Systems product webpage

citations: 10

Reference
Morimoto J, Matsumoto M, Miyazawa R, Yoshida H, Tsuneyama K, Matsumoto M. Aire suppresses CTLA-4 expression from the thymic stroma to control autoimmunity. Cell Rep. 2022;38:110384 pubmed publisher
Guiteras J, de Ramon L, Crespo E, Bolaños N, Barceló Batllori S, Martinez Valenzuela L, et al. Dual and Opposite Costimulatory Targeting with a Novel Human Fusion Recombinant Protein Effectively Prevents Renal Warm Ischemia Reperfusion Injury and Allograft Rejection in Murine Models. Int J Mol Sci. 2021;22: pubmed publisher
Li L, Jay S, Wang Y, Wu S, Xiao Z. IL-12 stimulates CTLs to secrete exosomes capable of activating bystander CD8+ T cells. Sci Rep. 2017;7:13365 pubmed publisher
Stojanovic A, Fiegler N, Brunner Weinzierl M, Cerwenka A. CTLA-4 is expressed by activated mouse NK cells and inhibits NK Cell IFN-? production in response to mature dendritic cells. J Immunol. 2014;192:4184-91 pubmed publisher
Kloog Y, Mor A. Cytotoxic-T-lymphocyte antigen 4 receptor signaling for lymphocyte adhesion is mediated by C3G and Rap1. Mol Cell Biol. 2014;34:978-88 pubmed publisher
Drees J, Augustin L, Mertensotto M, Schottel J, Leonard A, Saltzman D. Soluble production of a biologically active single-chain antibody against murine PD-L1 in Escherichia coli. Protein Expr Purif. 2014;94:60-6 pubmed publisher
Hammerbeck C, Mescher M. Antigen controls IL-7R alpha expression levels on CD8 T cells during full activation or tolerance induction. J Immunol. 2008;180:2107-16 pubmed
Butte M, Keir M, Phamduy T, Sharpe A, Freeman G. Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. Immunity. 2007;27:111-22 pubmed
Pentcheva Hoang T, Egen J, Wojnoonski K, Allison J. B7-1 and B7-2 selectively recruit CTLA-4 and CD28 to the immunological synapse. Immunity. 2004;21:401-13 pubmed
Shin T, Kennedy G, Gorski K, Tsuchiya H, Koseki H, Azuma M, et al. Cooperative B7-1/2 (CD80/CD86) and B7-DC costimulation of CD4+ T cells independent of the PD-1 receptor. J Exp Med. 2003;198:31-8 pubmed

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

740-B1

SKU :

740-B1-100

product name :

Recombinant Mouse B7-1/CD80 Fc Chimera His-tag Protein, CF

Description :

The Recombinant Mouse B7-1/CD80 Fc Chimera His-tag Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse B7-1/CD80 Fc Chimera His-tag Protein, CF has been validated for the following applications: Bioactivity.

target :

B7-1/CD80

category :

Proteins and Enzymes

unit size :

100 ug (also 1 mg)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Mouse

observed molecular weight :

80-90 kDa, reducing conditions

theoretical molecular weight :

51.3 kDa (monomer)

gene symbol :

Cd80

details of functionality :

Measured by its ability to induce IL-2 secretion by Jurkat human acute T cell leukemia cells. Freeman, G.J. et al . (1993) Science 262 :909. The ED50 for this effect is 5-30 ng/mL in the presence of PHA.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

Q00609

applications :

Bioactivity

source :

NS0-derived Recombinant Mouse B7-1/CD80 Fc Chimera His-tag Protein

USD :

423 USD

alt names :

Activation B7-1 antigen, B7, B71, BB1, CD28LG1, CD28LGB7-1 antigen), CD80, CD80 antigen, CD80 molecule, costimulatory factor CD80, costimulatory molecule variant IgV-CD80, CTLA-4 counter-receptor B7.1, T-lymphocyte activation antigen CD80

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage