product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Ephrin-B2 Fc Chimera Protein, CF
catalog :
7397-EB-050
quantity :
50 ug
price :
432 USD
more info or order :
R&D Systems product webpage
citations: 12
Reference
Kim Y, Ahmed S, Miller W. Colorectal cancer-associated mutations impair EphB1 kinase function. J Biol Chem. 2023;:105115 pubmed publisher
Vreeken D, Bruikman C, Cox S, Zhang H, Lalai R, Koudijs A, et al. EPH receptor B2 stimulates human monocyte adhesion and migration independently of its EphrinB ligands. J Leukoc Biol. 2020;: pubmed publisher
Luxan G, Stewen J, Díaz N, Kato K, Maney S, Aravamudhan A, et al. Endothelial EphB4 maintains vascular integrity and transport function in adult heart. elife. 2019;8: pubmed publisher
Hilal R, Poittevin M, Pasteur Rousseau A, Cogo A, Mangin G, Chevauché M, et al. Diabetic Ephrin-B2-Stimulated Peripheral Blood Mononuclear Cells Enhance Poststroke Recovery in Mice. Stem Cells Int. 2018;2018:2431567 pubmed publisher
You C, Zhao K, Dammann P, Keyvani K, Kreitschmann Andermahr I, Sure U, et al. EphB4 forward signalling mediates angiogenesis caused by CCM3/PDCD10-ablation. J Cell Mol Med. 2017;21:1848-1858 pubmed publisher
Fuggetta M, Bordignon V, Cottarelli A, Macchi B, Frezza C, Cordiali Fei P, et al. Downregulation of proinflammatory cytokines in HTLV-1-infected T cells by Resveratrol. J Exp Clin Cancer Res. 2016;35:118 pubmed publisher
Martin Almedina S, Martínez Corral I, Holdhus R, Vicente A, Fotiou E, Lin S, et al. EPHB4 kinase-inactivating mutations cause autosomal dominant lymphatic-related hydrops fetalis. J Clin Invest. 2016;126:3080-8 pubmed publisher
Lisle J, Mertens Walker I, Stephens C, Stansfield S, Clements J, Herington A, et al. Murine, but not human, ephrin-B2 can be efficiently cleaved by the serine protease kallikrein-4: implications for xenograft models of human prostate cancer. Exp Cell Res. 2015;333:136-46 pubmed publisher
Kawasaki J, Aegerter S, Fevurly R, Mammoto A, Mammoto T, Sahin M, et al. RASA1 functions in EPHB4 signaling pathway to suppress endothelial mTORC1 activity. J Clin Invest. 2014;124:2774-84 pubmed publisher
Grafton K, Moir L, Black J, Hansbro N, Hansbro P, Burgess J, et al. LF-15 & T7, synthetic peptides derived from tumstatin, attenuate aspects of airway remodelling in a murine model of chronic OVA-induced allergic airway disease. PLoS ONE. 2014;9:e85655 pubmed publisher
Liu Q, Stone J, Bradel Tretheway B, Dabundo J, Benavides Montano J, Santos Montanez J, et al. Unraveling a three-step spatiotemporal mechanism of triggering of receptor-induced Nipah virus fusion and cell entry. PLoS Pathog. 2013;9:e1003770 pubmed publisher
Kida Y, Ieronimakis N, Schrimpf C, Reyes M, Duffield J. EphrinB2 reverse signaling protects against capillary rarefaction and fibrosis after kidney injury. J Am Soc Nephrol. 2013;24:559-72 pubmed publisher
product information
brand :
R&D Systems, a Bio-Techne brand
catalog number base :
7397-EB
SKU :
7397-EB-050
product name :
Recombinant Human Ephrin-B2 Fc Chimera Protein, CF
description :
The Recombinant Human Ephrin-B2 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Ephrin-B2 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.
target :
Ephrin-B2
unit size :
50 ug
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Human
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
observed molecular weight :
58-66 kDa, reducing conditions
theoretical molecular weight :
48.8 kDa (monomer)
gene symbol :
EFNB2
details of functionality :
Measured by its binding ability in a functional ELISA. When Recombinant Human EphB2 Fc Chimera (Catalog # 5189-B2 ) is coated at 2 µg/mL, Recombinant Human Ephrin-B2 Fc Chimera binds with an apparent Kd 0.1 nM. Also measured by its ability to enhance neurite outgrowth of E16-E18 rat embryonic cortical neuron.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
P52799
applications :
Bioactivity
product keywords :
7397-EB, rhEphrin-B2 Fc, hEphrin-B2, carrier-free, carrier free, 7397EB, EphrinB2, Ephrin-B 2, Ephrin B2
source :
NS0-derived Recombinant Human Ephrin-B2 Fc Chimera Protein, CF
USD :
423
USD 2025 :
432 USD
alt names :
EFNB2, ELF-2, ephrin B2, EphrinB2, EPLG5, Htk-L, HTKL, LERK5, LERK-5, NLERK-1
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.