Recombinant Canine IL-10 Protein, CF | R&D Systems 735-CL-010/CF product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Canine IL-10 Protein, CF

catalog :

735-CL-010/CF

quantity :

10 ug

price :

423 USD

more info or order :

R&D Systems product webpage

citations: 8

Reference
Pelst M, H xf6 bart C, de Rooster H, Devriendt B, Cox E. Immortalised canine buccal epithelial cells' CXCL8 secretion is affected by allergen extracts, Toll-like receptor ligands, IL-17A and calcitriol. Vet Res. 2022;53:72 pubmed publisher
Santos C, Costa S, Souza F, Mendes J, de Pinheiro C, Moreira D, et al. Blocking IL-10 signaling with soluble IL-10 receptor restores in vitro specific lymphoproliferative response in dogs with leishmaniasis caused by Leishmania infantum. PLoS ONE. 2021;16:e0239171 pubmed publisher
van Helvoort E, Popov Celeketić J, Eijkelkamp N, Coeleveld K, Tryfonidou M, Wijne C, et al. Canine IL4-10 fusion protein provides disease modifying activity in a canine model of OA; an exploratory study. PLoS ONE. 2019;14:e0219587 pubmed publisher
Santoro D, Ahrens K, Vesny R, Navarro C, Gatto H, Marsella R. Evaluation of the in vitro effect of Boldo and Meadowsweet plant extracts on the expression of antimicrobial peptides and inflammatory markers in canine keratinocytes. Res Vet Sci. 2017;115:255-262 pubmed publisher
Roatt B, Aguiar Soares R, Reis L, Cardoso J, Mathias F, de Brito R, et al. A Vaccine Therapy for Canine Visceral Leishmaniasis Promoted Significant Improvement of Clinical and Immune Status with Reduction in Parasite Burden. Front Immunol. 2017;8:217 pubmed publisher
Petitdidier E, Pagniez J, Papierok G, Vincendeau P, Lemesre J, Bras Gonçalves R. Recombinant Forms of Leishmania amazonensis Excreted/Secreted Promastigote Surface Antigen (PSA) Induce Protective Immune Responses in Dogs. PLoS Negl Trop Dis. 2016;10:e0004614 pubmed publisher
Fujiwara R, Loukas A, Mendez S, Williamson A, Bueno L, Wang Y, et al. Vaccination with irradiated Ancylostoma caninum third stage larvae induces a Th2 protective response in dogs. Vaccine. 2006;24:501-9 pubmed
Strauss Ayali D, Baneth G, Shor S, Okano F, Jaffe C. Interleukin-12 augments a Th1-type immune response manifested as lymphocyte proliferation and interferon gamma production in Leishmania infantum-infected dogs. Int J Parasitol. 2005;35:63-73 pubmed

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

735-CL/CF

SKU :

735-CL-010/CF

product name :

Recombinant Canine IL-10 Protein, CF

Description :

The Recombinant Canine IL-10 Protein, CF from R&D Systems is derived from E. coli. The Recombinant Canine IL-10 Protein, CF has been validated for the following applications: Bioactivity.

target :

IL-10

category :

Proteins and Enzymes

unit size :

10 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Canine

theoretical molecular weight :

18.9 kDa

gene symbol :

IL10

details of functionality :

Measured in a cell proliferation assay using MC/9-2 mouse mast cells. Thompson-Snipes, L. et al . (1991) J. Exp. Med. 173 :507. The ED50 for this effect is 0.3-1 ng/mL.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

XP_855560

applications :

Bioactivity

source :

E. coli-derived Recombinant Canine IL-10 Protein

USD :

423 USD

alt names :

CSIF, CSIFMGC126450, Cytokine synthesis inhibitory factor, GVHDS, IL10, IL10A, IL-10MGC126451, interleukin 10, interleukin-10, TGIF

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage