product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse TGF-beta 2 Protein, CF
catalog :
7346-B2-005/CF
quantity :
5 ug
price :
307 USD
more info or order :
R&D Systems product webpage
citations: 22
Reference
Xiong L, Sun Y, Huang J, Ma P, Wang X, Wang J, et al. Long Non-Coding RNA H19 Prevents Lens Fibrosis through Maintaining Lens Epithelial Cell Phenotypes. Cells. 2022;11: pubmed publisher
Llori xe1 n Salvador M, Byrne E, Szczepan M, Little K, Chen M, Xu H. Complement activation contributes to subretinal fibrosis through the induction of epithelial-to-mesenchymal transition (EMT) in retinal pigment epithelial cells. J Neuroinflammation. 2022;19:182 pubmed publisher
Li X, Morgan C, Goff L, Doetzlhofer A. Follistatin promotes LIN28B-mediated supporting cell reprogramming and hair cell regeneration in the murine cochlea. Sci Adv. 2022;8:eabj7651 pubmed publisher
Sagner A, Zhang I, Watson T, Lazaro J, Melchionda M, Briscoe J. A shared transcriptional code orchestrates temporal patterning of the central nervous system. PLoS Biol. 2021;19:e3001450 pubmed publisher
Mehta V, Pang K, Givens C, Chen Z, Huang J, Sweet D, et al. Mechanical forces regulate endothelial-to-mesenchymal transition and atherosclerosis via an Alk5-Shc mechanotransduction pathway. Sci Adv. 2021;7: pubmed publisher
Farooq S, Ashour H. Type II Collagen-Specific B Cells Induce Immune Tolerance in Th1-Skewed, Th2-Skewed, and Arthritis-Prone Strains of Mice. Cells. 2021;10: pubmed publisher
Baxter P, Dando O, Emelianova K, He X, McKay S, Hardingham G, et al. Microglial identity and inflammatory responses are controlled by the combined effects of neurons and astrocytes. Cell Rep. 2021;34:108882 pubmed publisher
Girardi F, Taleb A, Ebrahimi M, Datye A, Gamage D, Peccate C, et al. TGFβ signaling curbs cell fusion and muscle regeneration. Nat Commun. 2021;12:750 pubmed publisher
Florez M, Matatall K, Jeong Y, Ortinau L, Shafer P, Lynch A, et al. Interferon Gamma Mediates Hematopoietic Stem Cell Activation and Niche Relocalization through BST2. Cell Rep. 2020;33:108530 pubmed publisher
Faralli J, Filla M, McDowell C, Peters D. Disruption of fibronectin fibrillogenesis affects intraocular pressure (IOP) in BALB/cJ mice. PLoS ONE. 2020;15:e0237932 pubmed publisher
Wang X, Wang B, Zhao N, Wang C, Huang M, Chen B, et al. Pharmacological Targeting of BET Bromodomains Inhibits Lens Fibrosis via Downregulation of MYC Expression. Invest Ophthalmol Vis Sci. 2019;60:4748-4758 pubmed publisher
Lange S, Banerjee I, Carrion K, Serrano R, Habich L, KAMENY R, et al. miR-486 is modulated by stretch and increases ventricular growth. JCI Insight. 2019;4: pubmed publisher
Forteza M, Polyzos K, Baumgartner R, Suur B, Mussbacher M, Johansson D, et al. Activation of the Regulatory T-Cell/Indoleamine 2,3-Dioxygenase Axis Reduces Vascular Inflammation and Atherosclerosis in Hyperlipidemic Mice. Front Immunol. 2018;9:950 pubmed publisher
Thiagarajan D, O Shea K, Sreejit G, Ananthakrishnan R, Quadri N, Li Q, et al. Aldose reductase modulates acute activation of mesenchymal markers via the ?-catenin pathway during cardiac ischemia-reperfusion. PLoS ONE. 2017;12:e0188981 pubmed publisher
Ross M, Esser A, Fox G, Schmieder A, Yang X, Hu G, et al. Bone-Induced Expression of Integrin β3 Enables Targeted Nanotherapy of Breast Cancer Metastases. Cancer Res. 2017;77:6299-6312 pubmed publisher
Oh B, Suh D, Bae D, Ha N, Choi Y, Yoo H, et al. Therapeutic effect of a novel histone deacetylase 6 inhibitor, CKD-L, on collagen-induced arthritis in vivo and regulatory T cells in rheumatoid arthritis in vitro. Arthritis Res Ther. 2017;19:154 pubmed publisher
Latil M, Nassar D, Beck B, Boumahdi S, Wang L, Brisebarre A, et al. Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition. Cell Stem Cell. 2017;20:191-204.e5 pubmed publisher
Okamura T, Sumitomo S, Morita K, Iwasaki Y, Inoue M, Nakachi S, et al. TGF-β3-expressing CD4+CD25(-)LAG3+ regulatory T cells control humoral immune responses. Nat Commun. 2015;6:6329 pubmed publisher
Trembley M, Velasquez L, de Mesy Bentley K, Small E. Myocardin-related transcription factors control the motility of epicardium-derived cells and the maturation of coronary vessels. Development. 2015;142:21-30 pubmed publisher
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Korol A, Pino G, Dwivedi D, Robertson J, Deschamps P, West Mays J. Matrix metalloproteinase-9-null mice are resistant to TGF-?-induced anterior subcapsular cataract formation. Am J Pathol. 2014;184:2001-12 pubmed publisher
Guo T, Landsman L, Li N, Hebrok M. Factors expressed by murine embryonic pancreatic mesenchyme enhance generation of insulin-producing cells from hESCs. Diabetes. 2013;62:1581-92 pubmed publisher
product information
brand :
R&D Systems
master code :
7346-B2/CF
SKU :
7346-B2-005/CF
product name :
Recombinant Mouse TGF-beta 2 Protein, CF
description :
The Recombinant Mouse TGF-beta 2 Protein, CF from R&D Systems is derived from CHO. The Recombinant Mouse TGF-beta 2 Protein, CF has been validated for the following applications: Bioactivity.
target :
TGF-beta 2
category :
Proteins and Enzymes
unit sizes :
5 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in HCl.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Mouse
observed molecular weight :
10 kDa, reducing conditions
theoretical molecular weight :
12.7 kDa
gene symbol :
Tgfb2
details of functionality :
Measured by its ability to inhibit the IL-4-dependent proliferation of HT-2 mouse T cells. Tsang, M. et al . (1995) Cytokine 7 :389. The ED50 for this effect is 0.05-0.3 ng/mL.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
NP_033393
applications :
Bioactivity
source :
CHO-derived Recombinant Mouse TGF-beta 2 Protein, CF
USD :
307 USD
alt names :
BSC-1 cell growth inhibitor, Cetermin, Glioblastoma-derived T-cell suppressor factor, G-TSF, MGC116892, Polyergin, TGFB2, TGFbeta 2, TGF-beta2, TGF-beta-2, transforming growth factor beta-2, transforming growth factor, beta 2
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.