Recombinant Human Laminin alpha 4 Protein, CF | R&D Systems 7340-A4-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Laminin alpha 4 Protein, CF

catalog :

7340-A4-050

quantity :

50 ug

price :

476 USD

more info or order :

R&D Systems product webpage

citations: 5

Reference
Gonzalez Porras M, Stojkova K, Vaicik M, Pelowe A, Goddi A, Carmona A, et al. Integrins and extracellular matrix proteins modulate adipocyte thermogenic capacity. Sci Rep. 2021;11:5442 pubmed publisher
Zheng B, Qu J, Ohuchida K, Feng H, Chong S, Yan Z, et al. LAMA4 upregulation is associated with high liver metastasis potential and poor survival outcome of Pancreatic Cancer. Theranostics. 2020;10:10274-10289 pubmed publisher
Nakamura M, Shiozawa S, Tsuboi D, Amano M, Watanabe H, Maeda S, et al. Pathological Progression Induced by the Frontotemporal Dementia-Associated R406W Tau Mutation in Patient-Derived iPSCs. Stem Cell Reports. 2019;13:684-699 pubmed publisher
Burgett M, Lathia J, Roth P, Nowacki A, Galileo D, Pugacheva E, et al. Direct contact with perivascular tumor cells enhances integrin ?v?3 signaling and migration of endothelial cells. Oncotarget. 2016;7:43852-43867 pubmed publisher
Ishikawa T, Wondimu Z, Oikawa Y, Ingerpuu S, Virtanen I, Patarroyo M. Monoclonal antibodies to human laminin ?4 chain globular domain inhibit tumor cell adhesion and migration on laminins 411 and 421, and binding of ?6?1 integrin and MCAM to ?4-laminins. Matrix Biol. 2014;36:5-14 pubmed publisher

product information

brand :

R&D Systems

master code :

7340-A4

SKU :

7340-A4-050

product name :

Recombinant Human Laminin alpha 4 Protein, CF

description :

The Recombinant Human Laminin alpha 4 Protein, CF from R&D Systems is derived from CHO. The Recombinant Human Laminin alpha 4 Protein, CF has been validated for the following applications: Bioactivity.

target :

Laminin alpha 4

category :

Proteins and Enzymes

unit sizes :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

110-120 kDa, reducing conditions

theoretical molecular weight :

111 kDa

gene symbol :

LAMA4

details of functionality :

Measured by the ability of the immobilized protein to support the adhesion of HT1080 human fibrosarcoma cells. The ED50 for this effect is 0.7-2.8 µg/mL. Optimal dilutions should be determined by each laboratory for each application.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

EAW48267

applications :

Bioactivity

source :

CHO-derived Recombinant Human Laminin alpha 4 Protein, CF

USD :

476 USD

alt names :

DKFZp686D23145, LAMA3LAMA4*-1, LAMA4, laminin alpha 4 chain, laminin subunit alpha-4, laminin, alpha 4, Laminin-14 subunit alpha, Laminin-8 subunit alpha, Laminin-9 subunit alpha

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage