product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human IL-6 (HEK293-expressed) Protein
catalog :
7270-IL-025
quantity :
25 ug
price :
297 USD
more info or order :
R&D Systems product webpage
citations: 9
Reference
Sarieva K, Hildebrand F, Kagermeier T, Yent xfc r Z, Becker K, Mayer S. Pluripotent stem cell-derived neural progenitor cells can be used to model effects of IL-6 on human neurodevelopment. Dis Model Mech. 2023;16: pubmed publisher
Barilli A, Recchia Luciani G, Visigalli R, Sala R, Soli M, Dall Asta V, et al. Cytokine-Induced iNOS in A549 Alveolar Epithelial Cells: A Potential Role in COVID-19 Lung Pathology. Biomedicines. 2023;11: pubmed publisher
de Ruiter R, Wisse L, Schoenmaker T, Yaqub M, S xe1 nchez Duffhues G, Eekhoff E, et al. TGF-Beta Induces Activin A Production in Dermal Fibroblasts Derived from Patients with Fibrodysplasia Ossificans Progressiva. Int J Mol Sci. 2023;24: pubmed publisher
Cai Z, Tian S, Klein T, Tu L, Geenen L, Koudstaal T, et al. Kynurenine metabolites predict survival in pulmonary arterial hypertension: A role for IL-6/IL-6Rα. Sci Rep. 2022;12:12326 pubmed publisher
Manshouri T, Veletic I, Li P, Yin C, Post S, Verstovsek S, et al. GLI1 activates pro-fibrotic pathways in myelofibrosis fibrocytes. Cell Death Dis. 2022;13:481 pubmed publisher
Ajay A, Zhao L, Vig S, Fujiwara M, Thakurela S, Jadhav S, et al. Deletion of STAT3 from Foxd1 cell population protects mice from kidney fibrosis by inhibiting pericytes trans-differentiation and migration. Cell Rep. 2022;38:110473 pubmed publisher
Chou C, Hua K, Chen M, Wu C, Hsu C, Wang J, et al. Discovery and characterization of a monoclonal antibody targeting a conformational epitope of IL-6/IL-6Rα to inhibit IL-6/ IL-6Rα/gp130 hexameric signaling complex formation. MAbs. 2022;14:2029675 pubmed publisher
Jadhav S, Tripathi S, Chandrekar A, Waikar S, Hsiao L. A novel antibody for the detection of alternatively spliced secreted KLOTHO isoform in human plasma. PLoS ONE. 2021;16:e0245614 pubmed publisher
Wada Y, Tokuda K, Morine Y, Okikawa S, Yamashita S, Ikemoto T, et al. The inhibitory effect of TU-100 on hepatic stellate cell activation in the tumor microenvironment. Oncotarget. 2020;11:4593-4604 pubmed publisher
product information
master code :
7270-IL
SKU :
7270-IL-025
product name :
Recombinant Human IL-6 (HEK293-expressed) Protein
unit size :
25 ug
description :
The Recombinant Human IL-6 (HEK293-expressed) Protein from R&D Systems is derived from HEK293. The Recombinant Human IL-6 (HEK293-expressed) Protein has been validated for the following applications: Bioactivity.
target :
IL-6
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
species :
Human
observed molecular weight :
22 kDa, reducing conditions
theoretical molecular weight :
20.8 kDa
gene symbol :
IL6
details of functionality :
Measured in a cell proliferation assay using T1165.85.2.1 mouse plasmacytoma cells. Nordan, R.P. etáal . (1987) J. Immunol. 139 :813. The ED50 for this effect is 0.1-0.6 ng/mL.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
top caption :
Recombinant Human IL-6 (HEK293-expressed) Protein Bioactivity
accessionNumbers :
P05231.1
applications :
Bioactivity
source long :
Human embryonic kidney cell, HEK293-derived human IL-6 protein Val30-Met212
source short :
HEK293
USD :
297 USD
alt names :
B-cell differentiation factor, B-cell stimulatory factor 2, BSF2, BSF-2, CDF, CTL differentiation factor, HSF, hybridoma growth factor, IFNB2, IFN-beta-2, IL6, IL-6, Interferon beta-2, interleukin 6 (interferon, beta 2), interleukin BSF-2, interleukin-6, MGI-2A
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.