This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Human CTLA-4 Fc Chimera (CHO-expressed), CF
catalog :
7268-CT
quantity :
100 ug
price :
379 USD
citations: 1
Reference
Ramagopal U, Liu W, Garrett Thomson S, Bonanno J, Yan Q, Srinivasan M, et al. Structural basis for cancer immunotherapy by the first-in-class checkpoint inhibitor ipilimumab. Proc Natl Acad Sci U S A. 2017;114:E4223-E4232 pubmed publisher
product information
brand :
R&D Systems
master code :
7268-CT
SKU :
7268-CT-100
product name :
Recombinant Human CTLA-4 Fc Chimera (CHO-expressed), CF
description :
The Recombinant Human CTLA-4 Fc Chimera (CHO-expressed), CF from R&D Systems is derived from CHO. The Recombinant Human CTLA-4 Fc Chimera (CHO-expressed), CF has been validated for the following applications: Bioactivity.
target :
CTLA-4
category :
Proteins and Enzymes
unit size :
100 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Human
observed molecular weight :
53-58 kDa, reducing conditions
theoretical molecular weight :
40.1 kDa (monomer)
gene symbol :
CTLA4
details of functionality :
Measured by its ability to inhibit IL-2 secretion by stimulated Jurkat human acute T cell leukemia cells. Linsley, P.S. et al . (1991) J. Exp. Med. 174 :561. The ED50 for this effect is 0.03-0.15 µg/mL when stimulated with 1 µg/mL Recombinant Human B7-1/CD80 Fc Chimera (Catalog # 140-B1 ).
endotoxin note :
<0.01 EU per 1 µg of the protein by the LAL method.
catalog number base :
7268-CT
accessionNumbers :
P16410
applications :
Bioactivity
source :
Chinese Hamster Ovary cell line, CHO-derived human CTLA-4 protein Human CTLA-4 (Ala37-Phe162) Accession # P16410 IEGRMD Human IgG1 (Pro100-Lys330) N-terminus C-terminus
2020 USD :
379
2021 USD :
379 USD
alt names :
CD, CD152, CD152 antigen, CD152IDDM12, CD28, celiac disease 3, CELIAC3, CTLA4, CTLA-4, cytotoxic T-lymphocyte antigen 4, cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4, cytotoxic T-lymphocyte-associated protein 4, cytotoxic T-lymphocyte-associated serine esterase-4, GRD4, GSE, ICOS, ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.