Recombinant Human CTLA-4 Fc Chimera (CHO-expressed), CF | R&D Systems 7268-CT-100 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human CTLA-4 Fc Chimera (CHO-expressed), CF

catalog :

7268-CT-100

quantity :

100 ug

price :

480 USD

more info or order :

R&D Systems product webpage

citations: 3

Reference
Hanson A, Elpek K, Duong E, Shallberg L, Fan M, Johnson C, et al. ICOS agonism by JTX-2011 (vopratelimab) requires initial T cell priming and Fc cross-linking for optimal T cell activation and anti-tumor immunity in preclinical models. PLoS ONE. 2020;15:e0239595 pubmed publisher
Garrett Thomson S, Massimi A, Fedorov E, Bonanno J, Scandiuzzi L, Hillerich B, et al. Mechanistic dissection of the PD-L1:B7-1 co-inhibitory immune complex. PLoS ONE. 2020;15:e0233578 pubmed publisher
Ramagopal U, Liu W, Garrett Thomson S, Bonanno J, Yan Q, Srinivasan M, et al. Structural basis for cancer immunotherapy by the first-in-class checkpoint inhibitor ipilimumab. Proc Natl Acad Sci U S A. 2017;114:E4223-E4232 pubmed publisher

image

image 1 :

Recombinant Human CTLA-4 Fc Chimera (CHO-expressed) Bioactivity

product information

brand :

R&D Systems, a Bio-Techne brand

catalog number base :

7268-CT

SKU :

7268-CT-100

product name :

Recombinant Human CTLA-4 Fc Chimera (CHO-expressed), CF

description :

The Recombinant Human CTLA-4 Fc Chimera (CHO-expressed), CF from R&D Systems is derived from CHO. The Recombinant Human CTLA-4 Fc Chimera (CHO-expressed), CF has been validated for the following applications: Bioactivity.

target :

CTLA-4

unit size :

100 ug

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

observed molecular weight :

53-58 kDa, reducing conditions

theoretical molecular weight :

40.1 kDa (monomer)

gene symbol :

CTLA4

details of functionality :

Measured by its ability to inhibit IL-2 secretion by stimulated Jurkat human acute T cell leukemia cells. Linsley, P.S. et al . (1991) J. Exp. Med. 174 :561. The ED50 for this effect is 0.03-0.15 µg/mL when stimulated with 1 µg/mL Recombinant Human B7-1/CD80 Fc Chimera (Catalog # 140-B1 ).

endotoxin note :

<0.01 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

P16410

applications :

Bioactivity

product keywords :

7268-CT, rhCTLA-4 Fc, hCTLA-4, carrier-free, carrier free, b7 family, 7268CT, immunechecktargets, CTLA4, CTLA 4, B7family

source :

CHO-derived Recombinant Human CTLA-4 Fc Chimera (CHO-expressed), CF

USD :

470

USD 2025 :

480 USD

alt names :

CD, CD152, CD152 antigen, CD152IDDM12, CD28, celiac disease 3, CELIAC3, CTLA4, CTLA-4, cytotoxic T-lymphocyte antigen 4, cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4, cytotoxic T-lymphocyte-associated protein 4, cytotoxic T-lymphocyte-associated serine esterase-4, GRD4, GSE, ICOS, ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4

more info or order :

R&D Systems product webpage