Recombinant Human TNF RII/TNFRSF1B Fc Chimera Protein, CF | R&D Systems 726-R2-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human TNF RII/TNFRSF1B Fc Chimera Protein, CF

catalog :

726-R2-050

quantity :

50 ug

price :

423 USD

more info or order :

R&D Systems product webpage

citations: 5

Reference
Inoue M, Ando D, Kamada H, Taki S, Niiyama M, Mukai Y, et al. A trimeric structural fusion of an antagonistic tumor necrosis factor-Î± mutant enhances molecular stability and enables facile modification. J Biol Chem. 2017;292:6438-6451 pubmed publisher
Dulos J, van der Vleuten M, Kavelaars A, Heijnen C, Boots A. CYP7B expression and activity in fibroblast-like synoviocytes from patients with rheumatoid arthritis: regulation by proinflammatory cytokines. Arthritis Rheum. 2005;52:770-8 pubmed
Jyonouchi H, Sun S, Itokazu N. Innate immunity associated with inflammatory responses and cytokine production against common dietary proteins in patients with autism spectrum disorder. Neuropsychobiology. 2002;46:76-84 pubmed
Ryon J, Moss W, Monze M, Griffin D. Functional and phenotypic changes in circulating lymphocytes from hospitalized zambian children with measles. Clin Diagn Lab Immunol. 2002;9:994-1003 pubmed
Bharucha A, Jorgensen R, Lichtman S, LaRusso N, Lindor K. A pilot study of pentoxifylline for the treatment of primary sclerosing cholangitis. Am J Gastroenterol. 2000;95:2338-42 pubmed

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

726-R2

SKU :

726-R2-050

product name :

Recombinant Human TNF RII/TNFRSF1B Fc Chimera Protein, CF

Description :

The Recombinant Human TNF RII/TNFRSF1B Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human TNF RII/TNFRSF1B Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

TNF RII/TNFRSF1B

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

70 kDa, reducing conditions

theoretical molecular weight :

52.6 kDa (monomer)

gene symbol :

TNFRSF1B

details of functionality :

Measured by its ability to inhibit the TNF-alpha mediated cytotoxicity in the L-929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D. Matthews, N. and M.L. Neale (1987) in Lymphokines and Interferons, A Practical Approach. Clemens, M.J. et al . (eds): IRL Press. 221. The ED50 for this effect, in the presence of 0.25 ng/mL of TNF-alpha , is 0.004-0.016 µg/mL.

endotoxin note :

<0.01 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

AAA36755

applications :

Bioactivity

source :

NS0-derived Recombinant Human TNF RII/TNFRSF1B Fc Chimera Protein

extended description :

His-tag

USD :

423 USD

product details :

His-tag

alt names :

CD120b, CD120b antigen, Etanercept, p75 TNF receptor, p75TBPII, p75TNFR, soluble TNFR1B variant 1, TNFBRp80 TNF-alpha receptor, TNF-R2, TNFR2TNFR1B, TNF-R75, TNFR80, TNFRII, TNF-RII, TNF-R-II, TNFR-II, TNFRSF1B, tumor necrosis factor beta receptor, tumor necrosis factor binding protein 2, Tumor necrosis factor receptor 2, tumor necrosis factor receptor superfamily member 1B, tumor necrosis factor receptor superfamily, member 1B, Tumor necrosis factor receptor type II

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage