Recombinant Mouse TRAIL R2/TNFRSF10B Fc Chimera Protein, CF | R&D Systems 721-DR-100 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse TRAIL R2/TNFRSF10B Fc Chimera Protein, CF

catalog :

721-DR-100

quantity :

100 ug

price :

456 USD

citations: 2

Reference
Luo Y, Hao H, Wang Z, Ong C, Dutcher R, Xu Y, et al. Heparan sulfate promotes TRAIL-induced tumor cell apoptosis. bioRxiv. 2023;: pubmed publisher
Park J, Oh Y, Park Y, Park O, Yang H, Slania S, et al. Targeting of dermal myofibroblasts through death receptor 5 arrests fibrosis in mouse models of scleroderma. Nat Commun. 2019;10:1128 pubmed publisher

product information

master code :

721-DR

SKU :

721-DR-100

product name :

Recombinant Mouse TRAIL R2/TNFRSF10B Fc Chimera Protein, CF

unit size :

100 ug

description :

The Recombinant Mouse TRAIL R2/TNFRSF10B Fc Chimera Protein, CF from R&D Systems is derived from Sf 21 (baculovirus). The Recombinant Mouse TRAIL R2/TNFRSF10B Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

TRAIL R2/TNFRSF10B

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Mouse

observed molecular weight :

49 kDa, reducing conditions

theoretical molecular weight :

40 kDa (monomer)

gene symbol :

Tnfrsf10b

details of functionality :

Measured by its ability to inhibit TRAIL-mediated cytotoxicity using L-929 mouse fibroblast cells treated with TRAIL. The ED50 for this effect is 3-12áng/mL in the presence of 20 ng/mL of rhTRAIL or 12áng/mL cross-linked rhTRAIL (Catalog # 375-TL and MAB050).

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q6GSD9

applications :

Bioactivity

source long :

Spodoptera frugiperda , Sf 21 (baculovirus)-derived mouse TRAIL R2/TNFRSF10B protein Mouse TRAIL R2 (Asn53 - Ser177) (Arg58 - Ser177) Accession # Q6GSD9 IEGRMD Human IgG1 (Pro100 - Lys330) N-terminus C-terminus

source short :

Sf 21 (baculovirus)

USD :

456 USD

alt names :

CD262, CD262 antigen, death domain containing receptor for TRAIL/Apo-2L, Death receptor 5, DR5, DR5TRICK2B, Fas-like protein, KILLER/DR5, KILLERapoptosis inducing protein TRICK2A/2B, TNF-related apoptosis-inducing ligand receptor 2, TNFRSF10B, TRAIL receptor 2, TRAILR2, TRAIL-R2apoptosis inducing receptor TRAIL-R2, TRAILR2cytotoxic TRAIL receptor-2, TRICK2, TRICK2A, TRICKB, tumor necrosis factor receptor superfamily member 10B, tumor necrosis factor receptor superfamily, member 10b, tumor necrosis factor receptor-like protein ZTNFR9, ZTNFR9

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.