Recombinant Mouse Noggin Fc Chimera Protein, CF | R&D Systems 719-NG-050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse Noggin Fc Chimera Protein, CF

catalog :

719-NG-050

quantity :

50 ug (also 10 ug, 100 ug)

price :

432 USD

citations: 20

Reference
Park D, Kozaki T, Tiwari S, Moreira M, Khalilnezhad A, Torta F, et al. iPS-cell-derived microglia promote brain organoid maturation via cholesterol transfer. Nature. 2023;623:397-405 pubmed publisher
Das S, Mondal A, Dey C, Chakraborty S, Bhowmik R, Karmakar S, et al. ER stress induces upregulation of transcription factor Tbx20 and downstream Bmp2 signaling to promote cardiomyocyte survival. J Biol Chem. 2023;299:103031 pubmed publisher
Bergström P, Trybala E, Eriksson C, Johansson M, Satir T, Widéhn S, et al. Herpes Simplex Virus 1 and 2 Infections during Differentiation of Human Cortical Neurons. Viruses. 2021;13: pubmed publisher
Ouahoud S, Jacobs R, Peppelenbosch M, Fuhler G, Heijmans J, Diks S, et al. Kinome-wide analysis of the effect of statins in colorectal cancer. Br J Cancer. 2021;124:1978-1987 pubmed publisher
Boswell B, Korol A, West Mays J, Musil L. Dual function of TGF? in lens epithelial cell fate: implications for secondary cataract. Mol Biol Cell. 2017;28:907-921 pubmed publisher
Bergström P, Agholme L, Nazir F, Satir T, Toombs J, Wellington H, et al. Amyloid precursor protein expression and processing are differentially regulated during cortical neuron differentiation. Sci Rep. 2016;6:29200 pubmed publisher
Sengle G, Carlberg V, Tufa S, Charbonneau N, Smaldone S, Carlson E, et al. Abnormal Activation of BMP Signaling Causes Myopathy in Fbn2 Null Mice. PLoS Genet. 2015;11:e1005340 pubmed publisher
Ueki Y, Wilken M, Cox K, Chipman L, Bermingham McDonogh O, Reh T. A transient wave of BMP signaling in the retina is necessary for MÃ¼ller glial differentiation. Development. 2015;142:533-43 pubmed publisher
Yamamoto Shiraishi Y, Kuroiwa A. Wnt and BMP signaling cooperate with Hox in the control of Six2 expression in limb tendon precursor. Dev Biol. 2013;377:363-74 pubmed publisher
Boswell B, Overbeek P, Musil L. Essential role of BMPs in FGF-induced secondary lens fiber differentiation. Dev Biol. 2008;324:202-12 pubmed publisher
Boswell B, Lein P, Musil L. Cross-talk between fibroblast growth factor and bone morphogenetic proteins regulates gap junction-mediated intercellular communication in lens cells. Mol Biol Cell. 2008;19:2631-41 pubmed publisher
Shiraki N, Yoshida T, Araki K, Umezawa A, Higuchi Y, Goto H, et al. Guided differentiation of embryonic stem cells into Pdx1-expressing regional-specific definitive endoderm. Stem Cells. 2008;26:874-85 pubmed publisher
Yao Y, Zebboudj A, Torres A, Shao E, BOSTROM K. Activin-like kinase receptor 1 (ALK1) in atherosclerotic lesions and vascular mesenchymal cells. Cardiovasc Res. 2007;74:279-89 pubmed
Lindsley R, Gill J, Kyba M, Murphy T, Murphy K. Canonical Wnt signaling is required for development of embryonic stem cell-derived mesoderm. Development. 2006;133:3787-96 pubmed
Reversade B, De Robertis E. Regulation of ADMP and BMP2/4/7 at opposite embryonic poles generates a self-regulating morphogenetic field. Cell. 2005;123:1147-60 pubmed
Holzschuh J, Wada N, Wada C, Schaffer A, Javidan Y, Tallafuss A, et al. Requirements for endoderm and BMP signaling in sensory neurogenesis in zebrafish. Development. 2005;132:3731-42 pubmed
Delaune E, Lemaire P, Kodjabachian L. Neural induction in Xenopus requires early FGF signalling in addition to BMP inhibition. Development. 2005;132:299-310 pubmed
Chang W, Brigande J, Fekete D, Wu D. The development of semicircular canals in the inner ear: role of FGFs in sensory cristae. Development. 2004;131:4201-11 pubmed
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Chang C, Morales M, Chou J, Chen H, Hoffer B, Wang Y. Bone morphogenetic proteins are involved in fetal kidney tissue transplantation-induced neuroprotection in stroke rats. Neuropharmacology. 2002;43:418-26 pubmed

product information

master code :

719-NG

SKU :

719-NG-050

product name :

Recombinant Mouse Noggin Fc Chimera Protein, CF

unit size :

50 ug (also 10 ug, 100 ug)

description :

The Recombinant Mouse Noggin Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse Noggin Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

Noggin

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS and EDTA.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Mouse

observed molecular weight :

55-60 kDa, reducing conditions

theoretical molecular weight :

50 kDa (monomer)

gene symbol :

Nog

details of functionality :

Measured by its ability to inhibit BMP-4-induced alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The ED50 for this effect is 0.06-0.3 ╡g/mL in the presence of 30 ng/mL of Recombinant Human BMP-4 (Catalog # 314-BP ).

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

top caption :

Recombinant Mouse Noggin Fc Chimera Protein Bioactivity

accessionNumbers :

U79163

applications :

Bioactivity

source long :

Mouse myeloma cell line, NS0-derived mouse Noggin protein Mouse Noggin (Leu20-Cys232) Accession # U79163 IEGRMD Human IgG1 (Pro100-Lys330) N-terminus C-terminus

source short :

NS0

USD :

432 USD

alt names :

NOG, noggin, SYM1, symphalangism 1 (proximal), synostoses (multiple) syndrome 1, SYNS1, SYNS1A

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.