Recombinant Mouse Angiopoietin-2 Protein, CF | R&D Systems 7186-AN-025/CF product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse Angiopoietin-2 Protein, CF

catalog :

7186-AN-025/CF

quantity :

25 ug

price :

373 USD

more info or order :

R&D Systems product webpage

citations: 7

Reference
Bae J, Yang M, Jeong S, Kim J, Hong S, Kim J, et al. Gatekeeping role of Nf2/Merlin in vascular tip EC induction through suppression of VEGFR2 internalization. Sci Adv. 2022;8:eabn2611 pubmed publisher
Luck R, Karakatsani A, Shah B, Schermann G, Adler H, Kupke J, et al. The angiopoietin-Tie2 pathway regulates Purkinje cell dendritic morphogenesis in a cell-autonomous manner. Cell Rep. 2021;36:109522 pubmed publisher
Helaine C, Ferré A, Leblond M, Pérès E, Bernaudin M, Valable S, et al. Angiopoietin-2 Combined with Radiochemotherapy Impedes Glioblastoma Recurrence by Acting in an Autocrine and Paracrine Manner: A Preclinical Study. Cancers (Basel). 2020;12: pubmed publisher
Gadomski S, Singh S, Singh S, Sarkar T, Klarmann K, Berenschot M, et al. Id1 and Id3 Maintain Steady-State Hematopoiesis by Promoting Sinusoidal Endothelial Cell Survival and Regeneration. Cell Rep. 2020;31:107572 pubmed publisher
Pedrosa A, Bodrug N, Gómez Escudero J, Carter E, Reynolds L, Georgiou P, et al. Tumor angiogenesis is differentially regulated by phosphorylation of endothelial cell focal adhesion kinase tyrosines-397 and -861. Cancer Res. 2019;: pubmed publisher
Kong H, Lee J, Youm H, Kim S, Lee J, Suh C, et al. Effect of treatment with angiopoietin-2 and vascular endothelial growth factor on the quality of xenografted bovine ovarian tissue in mice. PLoS ONE. 2017;12:e0184546 pubmed publisher
Youm H, Lee J, Kim E, Kong H, Lee J, Suh C, et al. Effects of Angiopoietin-2 on Transplanted Mouse Ovarian Tissue. PLoS ONE. 2016;11:e0166782 pubmed publisher

product information

master code :

7186-AN/CF

SKU :

7186-AN-025/CF

product name :

Recombinant Mouse Angiopoietin-2 Protein, CF

unit size :

25 ug

description :

The Recombinant Mouse Angiopoietin-2 Protein, CF from R&D Systems is derived from CHO. The Recombinant Mouse Angiopoietin-2 Protein, CF has been validated for the following applications: Bioactivity.

target :

Angiopoietin-2

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in HEPES, NaCl and CHAPS with Trehalose.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Mouse

observed molecular weight :

60-66 kDa, reducing conditions

theoretical molecular weight :

49.7 kDa

gene symbol :

Angpt2

details of functionality :

Measured by its ability to activate Tie-2 in C6 rat glial cells transfected with human Tie-2. 1 ╡g/mL of Recombinant Mouse Angiopoietin-2 significantly induces phosphorylation of human Tie-2 in the presence of a cross-linking antibody, Mouse Anti-polyHistidine Monoclonal Antibody (Catalog # MAB050 ).

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

NP_031452

applications :

Bioactivity

source long :

Chinese Hamster Ovary cell line, CHO-derived mouse Angiopoietin-2 protein Met1-Phe496, with a C-terminal 6-His tag

source short :

CHO

USD :

373 USD

alt names :

AGPT2, ANG2, ANG-2, angiopoietin 2, angiopoietin-2, angiopoietin-2a, angiopoietin-2B, angiopoitin 2, ANGPT2, Tie2-ligand

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage