product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse R-Spondin 1 (CHO-expressed) Protein
catalog :
7150-RS-025
quantity :
25 ug (also 50 ug, 250 ug)
price :
288 USD
more info or order :
R&D Systems product webpage
citations: 13
Reference
Xie S, Zhang S, de Medeiros G, Liberali P, Skotheim J. The G1/S transition in mammalian stem cells in vivo is autonomously regulated by cell size. bioRxiv. 2024;: pubmed publisher
Hao J, Liu C, Gu Z, Yang X, Lan X, Guo X. Dysregulation of Wnt/β-catenin signaling contributes to intestinal inflammation through regulation of group 3 innate lymphoid cells. Nat Commun. 2024;15:2820 pubmed publisher
Wang T, Zhu Y, Chen L, Zhang W, Qi H, Shi X, et al. ESRRG-PKM2 axis reprograms metabolism to suppress esophageal squamous carcinoma progression and enhance anti-PD-1 therapy efficacy. J Transl Med. 2023;21:605 pubmed publisher
Hiroto A, Kim W, Pineda A, He Y, Lee D, Le V, et al. Stromal androgen signaling acts as tumor niches to drive prostatic basal epithelial progenitor-initiated oncogenesis. Nat Commun. 2022;13:6552 pubmed publisher
Hadefi A, Leprovots M, Thulliez M, Bastin O, Lefort A, Libert F, et al. Cold atmospheric plasma differentially affects cell renewal and differentiation of stem cells and APC-deficient-derived tumor cells in intestinal organoids. Cell Death Discov. 2022;8:66 pubmed publisher
Fu Z, Dean J, Xiong L, Dougherty M, Oliff K, Chen Z, et al. Mitochondrial transcription factor A in RORγt+ lymphocytes regulate small intestine homeostasis and metabolism. Nat Commun. 2021;12:4462 pubmed publisher
Dunbar K, Valanciute A, Lima A, Vinuela P, Jamieson T, Rajasekaran V, et al. Aspirin Rescues Wnt-Driven Stem-like Phenotype in Human Intestinal Organoids and Increases the Wnt Antagonist Dickkopf-1. Cell Mol Gastroenterol Hepatol. 2021;11:465-489 pubmed publisher
Dougherty M, Kudin O, Muhlbauer M, Neu J, Gharaibeh R, Jobin C. Gut microbiota maturation during early human life induces enterocyte proliferation via microbial metabolites. BMC Microbiol. 2020;20:205 pubmed publisher
Cai Y, Zhu G, Liu S, Pan Z, Quintero M, Poole C, et al. Indispensable role of the Ubiquitin-fold modifier 1-specific E3 ligase in maintaining intestinal homeostasis and controlling gut inflammation. Cell Discov. 2019;5:7 pubmed publisher
Eriguchi Y, Nakamura K, Yokoi Y, Sugimoto R, Takahashi S, Hashimoto D, et al. Essential role of IFN-γ in T cell-associated intestinal inflammation. JCI Insight. 2018;3: pubmed publisher
Greicius G, Kabiri Z, Sigmundsson K, Liang C, Bunte R, Singh M, et al. PDGFR?+ pericryptal stromal cells are the critical source of Wnts and RSPO3 for murine intestinal stem cells in vivo. Proc Natl Acad Sci U S A. 2018;115:E3173-E3181 pubmed publisher
Yin X, Yi H, Wang L, Wu W, Wu X, Yu L. RSPOs facilitated HSC activation and promoted hepatic fibrogenesis. Oncotarget. 2016;7:63767-63778 pubmed publisher
Fernandez Vallone V, Leprovots M, Strollo S, Vasile G, Lefort A, Libert F, et al. Trop2 marks transient gastric fetal epithelium and adult regenerating cells after epithelial damage. Development. 2016;143:1452-63 pubmed publisher
product information
brand :
R&D Systems
catalog number base :
7150-RS
SKU :
7150-RS-025
product name :
Recombinant Mouse R-Spondin 1 (CHO-expressed) Protein
units size :
25 ug (also 50 ug, 250 ug)
description :
The Recombinant Mouse R-Spondin 1 (CHO-expressed) Protein from R&D Systems is derived from CHO. The Recombinant Mouse R-Spondin 1 (CHO-expressed) Protein has been validated for the following applications: Bioactivity.
target :
R-Spondin 1
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.
conjugate :
Unconjugated
all_available conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Mouse
observed molecular weight :
40-43 kDa, reducing conditions
theoretical molecular weight :
27 kDa
gene symbol :
Rspo1
details of functionality :
Measured by its ability to induce Topflash reporter activity in HEK293T human embryonic kidney cells. The typical ED50 is 8-40 ng/mL in the presence of 5 ng/mL Recombinant Mouse Wnt-3a (Catalog # 1324-WN ).
endotoxin note :
<0.01 EU per 1 µg of the protein by the LAL method.
top caption :
Recombinant Mouse R-Spondin 1 (CHO-expressed) Protein Bioactivity
accessionNumbers :
NP_619624
applications :
Bioactivity
source :
CHO-derived Recombinant Mouse R-Spondin 1 (CHO-expressed) Protein
USD :
288 USD
alt names :
Cristin 3, CRISTIN3, FLJ40906Roof plate-specific spondin-1, hRspo1, roof plate-specific spondin, RSPO, RSPO1, RSPONDIN, RSpondin 1, R-spondin homolog (Xenopus laevis), R-spondin1, R-spondin-1
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.