This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Human IL-13 R alpha 2 Fc Chimera (CHO), CF
catalog :
7147-IR
quantity :
100 ug
price :
379 USD
citations: 4
Reference
Brown C, Aguilar B, Starr R, Yang X, Chang W, Weng L, et al. Optimization of IL13Rα2-Targeted Chimeric Antigen Receptor T Cells for Improved Anti-tumor Efficacy against Glioblastoma. Mol Ther. 2018;26:31-44 pubmed publisher
Bielamowicz K, Fousek K, Byrd T, Samaha H, Mukherjee M, Aware N, et al. Trivalent CAR T-cells Overcome Interpatient Antigenic Variability in Glioblastoma. Neuro Oncol. 2017;: pubmed publisher
Mahadev V, Starr R, Wright S, Martinez C, Jensen M, Barish M, et al. Cytokine induction of VCAM-1 but not IL13R?2 on glioma cells: a tale of two antibodies. PLoS ONE. 2014;9:e95123 pubmed publisher
Hegde M, Corder A, Chow K, Mukherjee M, Ashoori A, Kew Y, et al. Combinational targeting offsets antigen escape and enhances effector functions of adoptively transferred T cells in glioblastoma. Mol Ther. 2013;21:2087-101 pubmed publisher
product information
brand :
R&D Systems
master code :
7147-IR
SKU :
7147-IR-100
product name :
Recombinant Human IL-13 R alpha 2 Fc Chimera (CHO), CF
description :
The Recombinant Human IL-13 R alpha 2 Fc Chimera (CHO), CF from R&D Systems is derived from CHO. The Recombinant Human IL-13 R alpha 2 Fc Chimera (CHO), CF has been validated for the following applications: Bioactivity.
target :
IL-13R alpha 2
category :
Proteins and Enzymes
unit size :
100 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Human
observed molecular weight :
75-95 kDa, reducing conditions
theoretical molecular weight :
64 kDa (monomer)
gene symbol :
IL13RA2
details of functionality :
Measured by its ability to inhibit IL-13-dependent proliferation of TF-1 human erythroleukemic cells. Kitamura, T. et al . (1989) J. Cell Physiol. 140 :323. The ED50 for this effect is 0.1-0.5 µg/mL in the presence of 8 ng/mL recombinant human IL-13.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
catalog number base :
7147-IR
accessionNumbers :
NP_000631
applications :
Bioactivity
source :
Chinese Hamster Ovary cell line, CHO-derived human IL-13 R alpha 2 protein Human IL-13 R alpha 2 (Met1-Leu342) Accession # NP_000631 IEGRMD Human IgG1 (Pro100-Lys330) N-terminus C-terminus
2020 USD :
379
2021 USD :
379 USD
alt names :
cancer/testis antigen 19, CD213a2, CD213a2 antigen, CT19, IL-13 receptor subunit alpha-2, IL13BP, IL13R, IL-13R, IL13R alpha 2, IL-13R subunit alpha-2, IL13RA2, IL-13RA2, IL-13R-alpha-2, interleukin 13 binding protein, interleukin 13 receptor alpha 2 chain, interleukin 13 receptor, alpha 2, interleukin-13 receptor subunit alpha-2, Interleukin-13-binding protein
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.