product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human GFR alpha-1 Fc Chimera Protein, CF
catalog :
714-GR-100
quantity :
100 ug
price :
394 USD
more info or order :
R&D Systems product webpage
citations: 11
Reference
Rhymes E, Tosolini A, Fellows A, Mahy W, McDonald N, Schiavo G. Bimodal regulation of axonal transport by the GDNF-RET signalling axis in healthy and diseased motor neurons. Cell Death Dis. 2022;13:584 pubmed publisher
Inglés Prieto A, Furthmann N, Crossman S, Tichy A, Hoyer N, Petersen M, et al. Optogenetic delivery of trophic signals in a genetic model of Parkinson's disease. PLoS Genet. 2021;17:e1009479 pubmed publisher
Ban K, Feng S, Shao L, Ittmann M. RET Signaling in Prostate Cancer. Clin Cancer Res. 2017;23:4885-4896 pubmed publisher
Meka D, Müller Rischart A, Nidadavolu P, Mohammadi B, Motori E, Ponna S, et al. Parkin cooperates with GDNF/RET signaling to prevent dopaminergic neuron degeneration. J Clin Invest. 2015;125:1873-85 pubmed publisher
Klein P, Müller Rischart A, Motori E, Schönbauer C, Schnorrer F, Winklhofer K, et al. Ret rescues mitochondrial morphology and muscle degeneration of Drosophila Pink1 mutants. EMBO J. 2014;33:341-55 pubmed publisher
Gatto G, Dudanova I, Suetterlin P, Davies A, Drescher U, Bixby J, et al. Protein tyrosine phosphatase receptor type O inhibits trigeminal axon growth and branching by repressing TrkB and Ret signaling. J Neurosci. 2013;33:5399-410 pubmed publisher
Lundgren T, Nakahata K, Fritz N, Rebellato P, Zhang S, Uhlen P. RET PLC? phosphotyrosine binding domain regulates Ca2+ signaling and neocortical neuronal migration. PLoS ONE. 2012;7:e31258 pubmed publisher
Lu B, PereiraPerrin M. A novel immunoprecipitation strategy identifies a unique functional mimic of the glial cell line-derived neurotrophic factor family ligands in the pathogen Trypanosoma cruzi. Infect Immun. 2008;76:3530-8 pubmed publisher
Tatsumi N, Miki R, Katsu K, Yokouchi Y. Neurturin-GFRalpha2 signaling controls liver bud migration along the ductus venosus in the chick embryo. Dev Biol. 2007;307:14-28 pubmed
Murase S, McKay R. A specific survival response in dopamine neurons at most risk in Parkinson's disease. J Neurosci. 2006;26:9750-60 pubmed
Carmillo P, Dagø L, Day E, Worley D, Rossomando A, Walus L, et al. Glial cell line-derived neurotrophic factor (GDNF) receptor alpha-1 (GFR alpha 1) is highly selective for GDNF versus artemin. Biochemistry. 2005;44:2545-54 pubmed
product information
brand :
R&D Systems
master code :
714-GR
SKU :
714-GR-100
product name :
Recombinant Human GFR alpha-1 Fc Chimera Protein, CF
description :
The Recombinant Human GFR alpha-1 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human GFR alpha-1 Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.
target :
GFR alpha-1/GDNF R alpha-1
category :
Proteins and Enzymes
unit sizes :
100 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS.
conjugate :
Unconjugated
purity :
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Human
observed molecular weight :
88-95 kDa, reducing conditions
theoretical molecular weight :
73.3 kDa (monomer)
gene symbol :
GFRA1
details of functionality :
Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human GDNF (Catalog # 212-GD ) at 1 µg/mL binds Recombinant Human GFR alpha-1/GDNF R alpha-1 Fc Chimera with an apparent Kd 2 nM.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
NP_665736
applications :
Binding Activity
source :
NS0-derived Recombinant Human GFR alpha-1 Fc Chimera Protein, CF
USD :
394 USD
alt names :
DKFZp313E1012, DKFZp686J0156, GDNF family receptor alpha 1, GDNF family receptor alpha-1, GDNF R alpha-1, GDNF receptor alpha-1, GDNFRAGFR-ALPHA-1, GDNFR-alpha-1, GDNFRMGC23045, GFR alpha1, GFRa-1, GFRA1, GFR-alpha-1, Glial cell line-derived neurotrophic factor receptor alpha, GPI-linked anchor protein, PI-linked cell-surface accessory protein, RET ligand 1, RET1L, RETL1FLJ10561, TGF-beta related neurotrophic factor receptor 1, TGF-beta-related neurotrophic factor receptor 1, TRNR1FLJ31546
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.