product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse FGFR3 (IIIc) Fc Chimera Protein, CF
catalog :
710-MF-050
quantity :
50 ug
price :
432 USD
more info or order :
R&D Systems product webpage
citations: 4
Reference
Min B, Yoo M, Kim H, Cho M, Nam D, Yoon Y. Semi-Automated Cell Panning for Efficient Isolation of FGFR3-Targeting Antibody. Int J Mol Sci. 2021;22: pubmed publisher
Nakayama T, Mutsuga N, Tosato G. FGF2 posttranscriptionally down-regulates expression of SDF1 in bone marrow stromal cells through FGFR1 IIIc. Blood. 2007;109:1363-72 pubmed
Steinberg Z, Myers C, Heim V, Lathrop C, Rebustini I, Stewart J, et al. FGFR2b signaling regulates ex vivo submandibular gland epithelial cell proliferation and branching morphogenesis. Development. 2005;132:1223-34 pubmed
Gunhaga L, Marklund M, Sjödal M, Hsieh J, Jessell T, Edlund T. Specification of dorsal telencephalic character by sequential Wnt and FGF signaling. Nat Neurosci. 2003;6:701-7 pubmed
product information
master code :
710-MF
SKU :
710-MF-050
product name :
Recombinant Mouse FGFR3 (IIIc) Fc Chimera Protein, CF
unit size :
50 ug
description :
The Recombinant Mouse FGFR3 (IIIc) Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse FGFR3 (IIIc) Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.
target :
FGFR3
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS.
conjugate :
Unconjugated
purity :
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Mouse
observed molecular weight :
100-110 kDa, reducing conditions
theoretical molecular weight :
63 kDa (monomer)
gene symbol :
Fgfr3
details of functionality :
Measured by its ability to inhibit FGF acidic-dependent proliferation of NR6R-3T3 mouse fibroblast cells. The ED50 for this effect is 2-6áng/mL.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
Q61851
applications :
Bioactivity
source long :
Mouse myeloma cell line, NS0-derived mouse FGF R3 protein Mouse FGF R3 (IIIc) (Ala33 - Tyr367) Accession # Q61851 IEGRMD Human IgG1 (Pro100 - Lys330) N-terminus C-terminus
source short :
NS0
USD :
432 USD
alt names :
CD333, CEK, EC 2.7.10, FGF R3, fibroblast growth factor receptor 3, HSFGFR3EX, JTK4, JTK4thanatophoric dwarfism
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.