product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse IL-36 alpha/IL-1F6 (aa 8-160) Protein, CF
catalog :
7059-ML-010/CF
quantity :
10 ug
price :
432 USD
more info or order :
R&D Systems product webpage
citations: 3
Reference
Muller A, Dickmanns A, Resch C, Schakel K, Hailfinger S, Dobbelstein M, et al. The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis. J Clin Invest. 2020;: pubmed publisher
Kurinna S, Muzumdar S, Köhler U, Kockmann T, auf dem Keller U, Schafer M, et al. Autocrine and Paracrine Regulation of Keratinocyte Proliferation through a Novel Nrf2-IL-36? Pathway. J Immunol. 2016;196:4663-70 pubmed publisher
Milora K, Fu H, Dubaz O, Jensen L. Unprocessed Interleukin-36α Regulates Psoriasis-Like Skin Inflammation in Cooperation With Interleukin-1. J Invest Dermatol. 2015;135:2992-3000 pubmed publisher
product information
master code :
7059-ML/CF
SKU :
7059-ML-010/CF
product name :
Recombinant Mouse IL-36 alpha/IL-1F6 (aa 8-160) Protein, CF
unit size :
10 ug
description :
The Recombinant Mouse IL-36 alpha/IL-1F6 (aa 8-160) Protein, CF from R&D Systems is derived from E. coli. The Recombinant Mouse IL-36 alpha/IL-1F6 (aa 8-160) Protein, CF has been validated for the following applications: Bioactivity.
target :
IL-36 alpha/IL-1F6
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in MOPS, NaCl, TCEP and EDTA with Trehalose.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
species :
Mouse
observed molecular weight :
16.5 kDa, reducing conditions
theoretical molecular weight :
17 kDa
gene symbol :
IL36A
details of functionality :
Measured by its ability to induce IL-6 secretion by NIH-3T3 mouse embryonic fibroblast cells. Towne, J.E. et al . (2004) J. Biol. Chem. 279 :13677. The ED50 for this effect is typically 3-18 ng/mL.
endotoxin note :
<0.01 EU per 1 ╡g of the protein by the LAL method.
top caption :
Recombinant Mouse IL-36 alpha/IL-1F6 (aa 8-160) Protein Bioactivity
accessionNumbers :
Q9JLA2
applications :
Bioactivity
source long :
E. coli -derived mouse IL-36 alpha/IL-1F6 protein Arg8-His160
source short :
E. coli
USD :
432 USD
alt names :
FIL1, FIL1 epsilon, FIL1(EPSILON), FIL1E, IL-1 epsilon, IL1(EPSILON), IL1E, IL-1E, IL1F6, IL-1F6, IL-1F6 (FIL-1-epsilon), IL36 alpha, IL36A, interleukin 1 family, member 6 (epsilon), interleukin 1, epsilon, Interleukin 36, Alpha, Interleukin-1 epsilon, interleukin-1 family member 6, Interleukin-36 Alpha
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.