Recombinant Mouse IL-36 gamma/IL-1F9 (aa 13-164) Protein, CF | R&D Systems 6996-IL-010/CF product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse IL-36 gamma/IL-1F9 (aa 13-164) Protein, CF

catalog :

6996-IL-010/CF

quantity :

10 ug

price :

394 USD

more info or order :

R&D Systems product webpage

citations: 6

Reference
El Awaisi J, Kavanagh D, Rink M, Weston C, Drury N, Kalia N. Targeting IL-36 improves age-related coronary microcirculatory dysfunction and attenuates myocardial ischemia/reperfusion injury in mice. JCI Insight. 2022;7: pubmed publisher
Zhang M, Liu J, Gao R, Hu Y, Lu L, Liu C, et al. Interleukin-36γ aggravates macrophage foam cell formation and atherosclerosis progression in ApoE knockout mice. Cytokine. 2021;146:155630 pubmed publisher
Gao N, Me R, Dai C, Seyoum B, Yu F. Opposing Effects of IL-1Ra and IL-36Ra on Innate Immune Response to Pseudomonas aeruginosa Infection in C57BL/6 Mouse Corneas. J Immunol. 2018;201:688-699 pubmed publisher
Ngo V, Abo H, Maxim E, Harusato A, Geem D, Medina Contreras O, et al. A cytokine network involving IL-36γ, IL-23, and IL-22 promotes antimicrobial defense and recovery from intestinal barrier damage. Proc Natl Acad Sci U S A. 2018;115:E5076-E5085 pubmed publisher
Kurinna S, Muzumdar S, Köhler U, Kockmann T, auf dem Keller U, Schafer M, et al. Autocrine and Paracrine Regulation of Keratinocyte Proliferation through a Novel Nrf2-IL-36? Pathway. J Immunol. 2016;196:4663-70 pubmed publisher
Bozoyan L, Dumas A, Patenaude A, ValliÃ¨res L. Interleukin-36Î³ is expressed by neutrophils and can activate microglia, but has no role in experimental autoimmune encephalomyelitis. J Neuroinflammation. 2015;12:173 pubmed publisher

image

image 1 :

Recombinant Mouse IL-36 gamma/IL-1F9 (aa 13-164) Protein Bioactivity

product information

brand :

R&D Systems

master code :

6996-IL/CF

SKU :

6996-IL-010/CF

product name :

Recombinant Mouse IL-36 gamma/IL-1F9 (aa 13-164) Protein, CF

description :

The Recombinant Mouse IL-36 gamma/IL-1F9 (aa 13-164) Protein, CF from R&D Systems is derived from E. coli. The Recombinant Mouse IL-36 gamma/IL-1F9 (aa 13-164) Protein, CF has been validated for the following applications: Bioactivity.

target :

IL-36 gamma/IL-1F9

category :

Proteins and Enzymes

unit sizes :

10 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in MES, NaCl, TCEP, EDTA, CHAPS and PEG 8000 with Trehalose.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Mouse

observed molecular weight :

17 kDa, reducing conditions

theoretical molecular weight :

17.3 kDa

gene symbol :

IL36G

details of functionality :

Measured by its ability to induce IL-6 secretion by NIH-3T3 mouse embryonic fibroblast cells. Towne, J.E. et al . (2004) J. Biol. Chem. 279 :13677. The ED50 for this effect is 3-18 ng/mL.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

Q8R460

applications :

Bioactivity

source :

E. coli-derived Recombinant Mouse IL-36 gamma/IL-1F9 (aa 13-164) Protein, CF

USD :

394 USD

alt names :

IL-1 epsilon, IL-1 H1, IL-1 Related Protein 2, IL-1(EPSILON), IL1E, IL-1-epsilon, IL1F9, IL-1F9, IL1H1, IL-1H1, IL-1-Related Protein 2, IL1RP2, IL-1RP2, IL36 gamma, IL36G, interleukin 1 family, member 9, interleukin 1-related protein 2, Interleukin 36, Gamma, Interleukin-1 epsilon, interleukin-1 family member 9, Interleukin-1 homolog 1, Interleukin-36 Gamma

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage