This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Human IL-36 alpha/IL-1F6 (aa 6-158) Protein
catalog :
6995-IL
quantity :
10 ug
price :
339 USD
citations: 4
Reference
Heath J, Scholz G, Veith P, Reynolds E. IL-36γ regulates mediators of tissue homeostasis in epithelial cells. Cytokine. 2019;119:24-31 pubmed publisher
Swindell W, Beamer M, Sarkar M, Loftus S, Fullmer J, Xing X, et al. RNA-Seq Analysis of IL-1B and IL-36 Responses in Epidermal Keratinocytes Identifies a Shared MyD88-Dependent Gene Signature. Front Immunol. 2018;9:80 pubmed publisher
Yi G, Ybe J, Saha S, Caviness G, Raymond E, Ganesan R, et al. Structural and Functional Attributes of the Interleukin-36 Receptor. J Biol Chem. 2016;291:16597-609 pubmed publisher
Saha S, Singh D, Raymond E, Ganesan R, Caviness G, Grimaldi C, et al. Signal Transduction and Intracellular Trafficking by the Interleukin 36 Receptor. J Biol Chem. 2015;290:23997-4006 pubmed publisher
product information
brand :
R&D Systems
master code :
6995-IL
SKU :
6995-IL-010
product name :
Recombinant Human IL-36 alpha/IL-1F6 (aa 6-158) Protein
description :
The Recombinant Human IL-36 alpha/IL-1F6 (aa 6-158) Protein from R&D Systems is derived from E. coli. The Recombinant Human IL-36 alpha/IL-1F6 (aa 6-158) Protein has been validated for the following applications: Bioactivity.
target :
IL-36 alpha/IL-1F6
category :
Proteins and Enzymes
unit size :
10 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in Tris, NaCl, TCEP, EDTA and Tween® 20 with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Human
observed molecular weight :
16 kDa, reducing conditions
theoretical molecular weight :
17 kDa
gene symbol :
IL36A
details of functionality :
Measured by its ability to induce IL-8 secretion in A431 human epithelial carcinoma cells. The ED50 for this effect is 4-24 ng/mL.
endotoxin note :
<0.01 EU per 1 µg of the protein by the LAL method.
catalog number base :
6995-IL
accessionNumbers :
NP_055255
applications :
Bioactivity
source :
E. coli -derived human IL-36 alpha/IL-1F6 protein Lys6-Phe158
2020 USD :
339
2021 USD :
339 USD
alt names :
FIL1, FIL1 epsilon, FIL1(EPSILON), FIL1E, IL-1 epsilon, IL1(EPSILON), IL1E, IL-1E, IL1F6, IL-1F6, IL-1F6 (FIL-1-epsilon), IL36 alpha, IL36A, interleukin 1 family, member 6 (epsilon), interleukin 1, epsilon, Interleukin 36, Alpha, Interleukin-1 epsilon, interleukin-1 family member 6, Interleukin-36 Alpha
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.