Recombinant Human IL-36 alpha/IL-1F6 (aa 6-158) Protein, CF | R&D Systems 6995-IL-010/CF product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human IL-36 alpha/IL-1F6 (aa 6-158) Protein, CF

catalog :

6995-IL-010/CF

quantity :

10 ug

price :

400 USD

more info or order :

R&D Systems product webpage

citations: 5

Reference
Muller A, Dickmanns A, Resch C, Schakel K, Hailfinger S, Dobbelstein M, et al. The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis. J Clin Invest. 2020;: pubmed publisher
Heath J, Scholz G, Veith P, Reynolds E. IL-36γ regulates mediators of tissue homeostasis in epithelial cells. Cytokine. 2019;119:24-31 pubmed publisher
Swindell W, Beamer M, Sarkar M, Loftus S, Fullmer J, Xing X, et al. RNA-Seq Analysis of IL-1B and IL-36 Responses in Epidermal Keratinocytes Identifies a Shared MyD88-Dependent Gene Signature. Front Immunol. 2018;9:80 pubmed publisher
Yi G, Ybe J, Saha S, Caviness G, Raymond E, Ganesan R, et al. Structural and Functional Attributes of the Interleukin-36 Receptor. J Biol Chem. 2016;291:16597-609 pubmed publisher
Saha S, Singh D, Raymond E, Ganesan R, Caviness G, Grimaldi C, et al. Signal Transduction and Intracellular Trafficking by the Interleukin 36 Receptor. J Biol Chem. 2015;290:23997-4006 pubmed publisher

product information

master code :

6995-IL/CF

SKU :

6995-IL-010/CF

product name :

Recombinant Human IL-36 alpha/IL-1F6 (aa 6-158) Protein, CF

unit size :

10 ug

description :

The Recombinant Human IL-36 alpha/IL-1F6 (aa 6-158) Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human IL-36 alpha/IL-1F6 (aa 6-158) Protein, CF has been validated for the following applications: Bioactivity.

target :

IL-36 alpha/IL-1F6

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in Tris, NaCl, TCEP, EDTA and Tween« 20 with Trehalose.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

observed molecular weight :

16 kDa, reducing conditions

theoretical molecular weight :

17 kDa

gene symbol :

IL36A

details of functionality :

Measured by its ability to induce IL-8 secretion in A431 human epithelial carcinoma cells. The ED50 for this effect is 4-24 ng/mL.

endotoxin note :

<0.01 EU per 1 ╡g of the protein by the LAL method.

top caption :

Recombinant Human IL-36 alpha/IL-1F6 (aa 6-158) Protein Bioactivity

accessionNumbers :

NP_055255

applications :

Bioactivity

source long :

E. coli -derived human IL-36 alpha/IL-1F6 protein Lys6-Phe158

source short :

E. coli

USD :

400 USD

alt names :

FIL1, FIL1 epsilon, FIL1(EPSILON), FIL1E, IL-1 epsilon, IL1(EPSILON), IL1E, IL-1E, IL1F6, IL-1F6, IL-1F6 (FIL-1-epsilon), IL36 alpha, IL36A, interleukin 1 family, member 6 (epsilon), interleukin 1, epsilon, Interleukin 36, Alpha, Interleukin-1 epsilon, interleukin-1 family member 6, Interleukin-36 Alpha

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage