product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human GITR Ligand/TNFSF18 (CHO-expressed)
catalog :
6987-GL-025
quantity :
25 ug
price :
432 USD
more info or order :
R&D Systems product webpage
citations: 1
Reference
Clarke A, Poulton L, Shim D, Mabon D, Butt D, Pollard M, et al. An anti-TL1A antibody for the treatment of asthma and inflammatory bowel disease. MAbs. 2018;10:664-677 pubmed publisher
product information
master code :
6987-GL
SKU :
6987-GL-025
product name :
Recombinant Human GITR Ligand/TNFSF18 (CHO-expressed)
unit size :
25 ug
description :
The Recombinant Human GITR Ligand/TNFSF18 (CHO-expressed) from R&D Systems is derived from CHO. The Recombinant Human GITR Ligand/TNFSF18 (CHO-expressed) has been validated for the following applications: Bioactivity.
target :
GITR Ligand/TNFSF18
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
species :
Human
observed molecular weight :
21-30 kDa, reducing conditions
theoretical molecular weight :
19.6 kDa (monomer)
gene symbol :
TNFSF18
details of functionality :
Measured by its ability to induce IL-8 secretion in HT1080 human fibrosarcoma cells transfected with human GITR. Wyzgol, A. et al . (2009) J. Immunol. 183 :1851. The ED50 for this effect is 4-20 ng/mL. The activity can be enhanced approximately 10-fold in the presence of Mouse Anti-Hemagglutinin/HA Peptide Monoclonal Antibody (Catalog # MAB060 ).
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
Q9UNG2.3
applications :
Bioactivity
source long :
Chinese Hamster Ovary cell line, CHO-derived human GITR Ligand/TNFSF18 protein Hemagglutinin Tag (YPYDVPDYA) GCN4-IZ GGGSGGGSGGGS Human GITR Ligand (Glu52-Ser177) Accession # Q9UNG2.3 N-terminus C-terminus
source short :
CHO
USD :
432 USD
alt names :
Activation-inducible TNF-related ligand, AITRL, AITRLMGC138237, GITRL, GITRLglucocorticoid-induced TNFR-related protein ligand, Glucocorticoid-induced TNF-related ligand, hGITRLGITR ligand, TL6AITR ligand, TNFSF18, tumor necrosis factor (ligand) superfamily, member 18, tumor necrosis factor ligand superfamily member 18
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.