product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse RANK/TNFRSF11A Fc Chimera Protein, CF
catalog :
692-RK-100
quantity :
100 ug
price :
456 USD
more info or order :
R&D Systems product webpage
citations: 4
Reference
Rotman S, Thompson K, Grijpma D, Richards R, Moriarty T, Eglin D, et al. Development of bone seeker-functionalised microspheres as a targeted local antibiotic delivery system for bone infections. J Orthop Translat. 2020;21:136-145 pubmed publisher
Shimamura M, Nakagami H, Osako M, Kurinami H, Koriyama H, Zhengda P, et al. OPG/RANKL/RANK axis is a critical inflammatory signaling system in ischemic brain in mice. Proc Natl Acad Sci U S A. 2014;111:8191-6 pubmed publisher
Aupperlee M, Zhao Y, Tan Y, Leipprandt J, Bennett J, Haslam S, et al. Epidermal growth factor receptor (EGFR) signaling is a key mediator of hormone-induced leukocyte infiltration in the pubertal female mammary gland. Endocrinology. 2014;155:2301-13 pubmed publisher
Nakamichi Y, Udagawa N, Kobayashi Y, Nakamura M, Yamamoto Y, Yamashita T, et al. Osteoprotegerin reduces the serum level of receptor activator of NF-kappaB ligand derived from osteoblasts. J Immunol. 2007;178:192-200 pubmed
product information
brand :
R&D Systems, a Bio-Techne brand
catalog number base :
692-RK
SKU :
692-RK-100
product name :
Recombinant Mouse RANK/TNFRSF11A Fc Chimera Protein, CF
description :
The Recombinant Mouse RANK/TNFRSF11A Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse RANK/TNFRSF11A Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.
target :
RANK/TNFRSF11A
unit size :
100 ug
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Mouse
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
observed molecular weight :
60 kDa, reducing conditions
theoretical molecular weight :
48 kDa (monomer)
gene symbol :
Tnfrsf11a
details of functionality :
Measured by its ability to inhibit TRANCE-induced osteoclast differentiation of mouse splenocytes. The ED50 for this effect is 0.05-0.15 µg/mL in the presence of 10 ng/mL of rmTRANCE.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
O35305.1
applications :
Bioactivity
product keywords :
692-RK, rmRANK/Fc, mRANK, carrier-free, carrier free, 692RK, TNFRSF 11A, TRANCER, cytokine, cytokines, cytokine receptor, cytokine receptors
source :
NS0-derived Recombinant Mouse RANK/TNFRSF11A Fc Chimera Protein, CF
USD :
447
USD 2025 :
456 USD
alt names :
CD265, CD265 antigen, FEO, loss of heterozygosity, 18, chromosomal region 1, ODFR, ODFROSTS, OFE, OPTB7, Osteoclast differentiation factor receptor, PDB2, RANKLOH18CR1, Receptor activator of NF-KB, receptor activator of nuclear factor-kappa B, TNFRSF11A, TRANCE R, TRANCER, tumor necrosis factor receptor superfamily member 11A, tumor necrosis factor receptor superfamily, member 11a, activator of NFKB, tumor necrosis factor receptor superfamily, member 11a, NFKB activator
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.