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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human TrkB Fc Chimera Protein, CF
catalog :
688-TK-100
quantity :
100 ug
price :
438 USD
more info or order :
citations: 51
Reference
Pavon M, Navakkode S, Wong L, Sajikumar S. Inhibition of Nogo-A rescues synaptic plasticity and associativity in APP/PS1 animal model of Alzheimer's disease. Semin Cell Dev Biol. 2022;: pubmed publisher
Zhou J, Geng Y, Su T, Wang Q, Ren Y, Zhao J, et al. NMDA receptor-dependent prostaglandin-endoperoxide synthase 2 induction in neurons promotes glial proliferation during brain development and injury. Cell Rep. 2022;38:110557 pubmed publisher
Petkova Tuffy A, Gödecke N, Viotti J, Korte M, Dresbach T. Neuroligin-1 mediates presynaptic maturation through brain-derived neurotrophic factor signaling. BMC Biol. 2021;19:215 pubmed publisher
Horvath P, Chanaday N, Alten B, Kavalali E, Monteggia L. A subthreshold synaptic mechanism regulating BDNF expression and resting synaptic strength. Cell Rep. 2021;36:109467 pubmed publisher
Zhang Y, Smolen P, Cleary L, Byrne J. Quantitative description of the interactions among kinase cascades underlying long-term plasticity of Aplysia sensory neurons. Sci Rep. 2021;11:14931 pubmed publisher
Lin Y, Yao M, Wu H, Wu F, Cao S, Ni H, et al. Environmental enrichment implies GAT-1 as a potential therapeutic target for stroke recovery. Theranostics. 2021;11:3760-3780 pubmed publisher
González Gutiérrez A, Lazo O, Bronfman F. The Rab5-Rab11 Endosomal Pathway is Required for BDNF-Induced CREB Transcriptional Regulation in Hippocampal Neurons. J Neurosci. 2020;40:8042-8054 pubmed publisher
Li X, Wang Q, Ding J, Wang S, Dong C, Wu Q. Exercise training modulates glutamic acid decarboxylase-65/67 expression through TrkB signaling to ameliorate neuropathic pain in rats with spinal cord injury. Mol Pain. 2020;16:1744806920924511 pubmed publisher
Patnaik A, Spiombi E, Frasca A, Landsberger N, Zagrebelsky M, Korte M. Fingolimod Modulates Dendritic Architecture in a BDNF-Dependent Manner. Int J Mol Sci. 2020;21: pubmed publisher
Fulgenzi G, Hong Z, Tomassoni Ardori F, Barella L, Becker J, Barrick C, et al. Novel metabolic role for BDNF in pancreatic β-cell insulin secretion. Nat Commun. 2020;11:1950 pubmed publisher
Montroull L, Danelon V, Cragnolini A, Mascó D. Loss of TrkB Signaling Due to Status Epilepticus Induces a proBDNF-Dependent Cell Death. Front Cell Neurosci. 2019;13:4 pubmed publisher
Hall J, Gomez Pinilla F, Savage L. Nerve Growth Factor Is Responsible for Exercise-Induced Recovery of Septohippocampal Cholinergic Structure and Function. Front Neurosci. 2018;12:773 pubmed publisher
Zhang H, Zhang C, Vincent J, Zala D, Benstaali C, Sainlos M, et al. Modulation of AMPA receptor surface diffusion restores hippocampal plasticity and memory in Huntington's disease models. Nat Commun. 2018;9:4272 pubmed publisher
Wu Q, Wang Q, Li Z, Li X, Zang J, Wang Z, et al. Human menstrual blood-derived stem cells promote functional recovery in a rat spinal cord hemisection model. Cell Death Dis. 2018;9:882 pubmed publisher
Li X, Wu Q, Xie C, Wang C, Wang Q, Dong C, et al. Blocking of BDNF-TrkB signaling inhibits the promotion effect of neurological function recovery after treadmill training in rats with spinal cord injury. Spinal Cord. 2019;57:65-74 pubmed publisher
Diniz C, Casarotto P, Fred S, Biojone C, Castren E, Joca S. Antidepressant-like effect of losartan involves TRKB transactivation from angiotensin receptor type 2 (AGTR2) and recruitment of FYN. Neuropharmacology. 2018;135:163-171 pubmed publisher
Suzuki A, Matsuura D, Kanatani H, Yano S, Tsunakawa M, Matsuyama S, et al. Inhibitory Effects of Polyacetylene Compounds from Panax ginseng on Neurotrophin Receptor-Mediated Hair Growth. Biol Pharm Bull. 2017;40:1784-1788 pubmed publisher
Hurtado Zavala J, Ramachandran B, Ahmed S, Halder R, Bolleyer C, Awasthi A, et al. TRPV1 regulates excitatory innervation of OLM neurons in the hippocampus. Nat Commun. 2017;8:15878 pubmed publisher
Sharma M, Dierkes T, Sajikumar S. Epigenetic regulation by G9a/GLP complex ameliorates amyloid-beta 1-42 induced deficits in long-term plasticity and synaptic tagging/capture in hippocampal pyramidal neurons. Aging Cell. 2017;16:1062-1072 pubmed publisher
Martins L, Costa R, Pedro J, Aguiar P, Serra S, Teixeira F, et al. Mesenchymal stem cells secretome-induced axonal outgrowth is mediated by BDNF. Sci Rep. 2017;7:4153 pubmed publisher
Nair R, Patil S, Tiron A, Kanhema T, Panja D, Schiro L, et al. Dynamic Arc SUMOylation and Selective Interaction with F-Actin-Binding Protein Drebrin A in LTP Consolidation In Vivo. Front Synaptic Neurosci. 2017;9:8 pubmed publisher
Guo Y, Su Z, Chen Y, Chai Z. Brain-derived neurotrophic factor/neurotrophin 3 regulate axon initial segment location and affect neuronal excitability in cultured hippocampal neurons. J Neurochem. 2017;142:260-271 pubmed publisher
Sleigh J, Dawes J, West S, Wei N, Spaulding E, Gómez Martín A, et al. Trk receptor signaling and sensory neuron fate are perturbed in human neuropathy caused by Gars mutations. Proc Natl Acad Sci U S A. 2017;114:E3324-E3333 pubmed publisher
Hildebrand M, Xu J, Dedek A, Li Y, Sengar A, Beggs S, et al. Potentiation of Synaptic GluN2B NMDAR Currents by Fyn Kinase Is Gated through BDNF-Mediated Disinhibition in Spinal Pain Processing. Cell Rep. 2016;17:2753-2765 pubmed publisher
Huang Y, Lee K, Grau J. Complete spinal cord injury (SCI) transforms how brain derived neurotrophic factor (BDNF) affects nociceptive sensitization. Exp Neurol. 2017;288:38-50 pubmed publisher
Hayashi Y, Morinaga S, Zhang J, Satoh Y, Meredith A, Nakata T, et al. BK channels in microglia are required for morphine-induced hyperalgesia. Nat Commun. 2016;7:11697 pubmed publisher
Sorge R, Mapplebeck J, Rosen S, Beggs S, Taves S, Alexander J, et al. Different immune cells mediate mechanical pain hypersensitivity in male and female mice. Nat Neurosci. 2015;18:1081-3 pubmed publisher
Obis T, Besalduch N, Hurtado E, Nadal L, Santafe M, Garcia N, et al. The novel protein kinase C epsilon isoform at the adult neuromuscular synapse: location, regulation by synaptic activity-dependent muscle contraction through TrkB signaling and coupling to ACh release. Mol Brain. 2015;8:8 pubmed publisher
Zhu G, Liu Y, Wang Y, Bi X, Baudry M. Different patterns of electrical activity lead to long-term potentiation by activating different intracellular pathways. J Neurosci. 2015;35:621-33 pubmed publisher
Bambah Mukku D, Travaglia A, Chen D, Pollonini G, Alberini C. A positive autoregulatory BDNF feedback loop via C/EBPβ mediates hippocampal memory consolidation. J Neurosci. 2014;34:12547-59 pubmed publisher
Bao Y, Hou W, Liu R, Gao Y, Kong X, Yang L, et al. PAR2-mediated upregulation of BDNF contributes to central sensitization in bone cancer pain. Mol Pain. 2014;10:28 pubmed publisher
Rittase W, Dong Y, Barksdale D, Galdzicki Z, Bausch S. Dynorphin up-regulation in the dentate granule cell mossy fiber pathway following chronic inhibition of GluN2B-containing NMDAR is associated with increased CREB (Ser 133) phosphorylation, but is independent of BDNF/TrkB signaling pathways. Mol Cell Neurosci. 2014;60:63-71 pubmed publisher
Vermehren Schmaedick A, KRUEGER W, Jacob T, Ramunno Johnson D, Balkowiec A, Lidke K, et al. Heterogeneous intracellular trafficking dynamics of brain-derived neurotrophic factor complexes in the neuronal soma revealed by single quantum dot tracking. PLoS ONE. 2014;9:e95113 pubmed publisher
Melemedjian O, Tillu D, Asiedu M, Mandell E, Moy J, Blute V, et al. BDNF regulates atypical PKC at spinal synapses to initiate and maintain a centralized chronic pain state. Mol Pain. 2013;9:12 pubmed publisher
Chen D, Bambah Mukku D, Pollonini G, Alberini C. Glucocorticoid receptors recruit the CaMKII?-BDNF-CREB pathways to mediate memory consolidation. Nat Neurosci. 2012;15:1707-14 pubmed publisher
Makino K, Kawamura K, Sato W, Kawamura N, Fujimoto T, Terada Y. Inhibition of uterine sarcoma cell growth through suppression of endogenous tyrosine kinase B signaling. PLoS ONE. 2012;7:e41049 pubmed publisher
Tsai C, Chan J, Hsu K, Chang A, Chan S. Brain-derived neurotrophic factor ameliorates brain stem cardiovascular dysregulation during experimental temporal lobe status epilepticus. PLoS ONE. 2012;7:e33527 pubmed publisher
Renn C, Leitch C, Lessans S, Rhee P, McGuire W, Smith B, et al. Brain-derived neurotrophic factor modulates antiretroviral-induced mechanical allodynia in the mouse. J Neurosci Res. 2011;89:1551-65 pubmed publisher
Vaegter C, Jansen P, Fjorback A, Glerup S, Skeldal S, Kjolby M, et al. Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling. Nat Neurosci. 2011;14:54-61 pubmed publisher
Huang Y, Lai P, Wu C, Hsu S, Cheng C, Lan Y, et al. BDNF mediated TrkB activation is a survival signal for transitional cell carcinoma cells. Int J Oncol. 2010;36:1469-76 pubmed
Fobian K, Owczarek S, Budtz C, Bock E, Berezin V, Pedersen M. Peptides derived from the solvent-exposed loops 3 and 4 of BDNF bind TrkB and p75(NTR) receptors and stimulate neurite outgrowth and survival. J Neurosci Res. 2010;88:1170-81 pubmed publisher
Endo T, Ajiki T, Inoue H, Kikuchi M, Yashiro T, Nakama S, et al. Early exercise in spinal cord injured rats induces allodynia through TrkB signaling. Biochem Biophys Res Commun. 2009;381:339-44 pubmed publisher
Gomez Pinilla F, Vaynman S, Ying Z. Brain-derived neurotrophic factor functions as a metabotrophin to mediate the effects of exercise on cognition. Eur J Neurosci. 2008;28:2278-87 pubmed publisher
Fitzgerald M, Buckley A, Lukehurst S, Dunlop S, Beazley L, Rodger J. Neurite responses to ephrin-A5 modulated by BDNF: evidence for TrkB-EphA interactions. Biochem Biophys Res Commun. 2008;374:625-30 pubmed publisher
Ying Z, Roy R, Zhong H, Zdunowski S, Edgerton V, Gomez Pinilla F. BDNF-exercise interactions in the recovery of symmetrical stepping after a cervical hemisection in rats. Neuroscience. 2008;155:1070-8 pubmed publisher
Lu B, PereiraPerrin M. A novel immunoprecipitation strategy identifies a unique functional mimic of the glial cell line-derived neurotrophic factor family ligands in the pathogen Trypanosoma cruzi. Infect Immun. 2008;76:3530-8 pubmed publisher
Xapelli S, Bernardino L, Ferreira R, Grade S, Silva A, Salgado J, et al. Interaction between neuropeptide Y (NPY) and brain-derived neurotrophic factor in NPY-mediated neuroprotection against excitotoxicity: a role for microglia. Eur J Neurosci. 2008;27:2089-102 pubmed publisher
Chytrova G, Ying Z, Gomez Pinilla F. Exercise normalizes levels of MAG and Nogo-A growth inhibitors after brain trauma. Eur J Neurosci. 2008;27:1-11 pubmed
Gomez Pinilla F, Huie J, Ying Z, Ferguson A, Crown E, Baumbauer K, et al. BDNF and learning: Evidence that instrumental training promotes learning within the spinal cord by up-regulating BDNF expression. Neuroscience. 2007;148:893-906 pubmed
Vaynman S, Ying Z, Yin D, Gomez Pinilla F. Exercise differentially regulates synaptic proteins associated to the function of BDNF. Brain Res. 2006;1070:124-30 pubmed
Esper R, Loeb J. Rapid axoglial signaling mediated by neuregulin and neurotrophic factors. J Neurosci. 2004;24:6218-27 pubmed
image
image 1 :
R&D Systems 688-TK-100 image 1
Recombinant Human TrkB Fc Chimera Protein Bioactivity
product information
brand :
R&D Systems
master code :
688-TK
SKU :
688-TK-100
product name :
Recombinant Human TrkB Fc Chimera Protein, CF
description :
The Recombinant Human TrkB Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human TrkB Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.
target :
TrkB
category :
Proteins and Enzymes
unit sizes :
100 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS.
conjugate :
Unconjugated
purity :
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Human
observed molecular weight :
120 kDa-130 kDa, reducing conditions
theoretical molecular weight :
71.7 kDa (monomer)
gene symbol :
NTRK2
details of functionality :
Measured by its ability to inhibit BDNF-induced proliferation of BaF-TrkB-BD mouse pro-B cells transfected with TrkB. The ED50 for this effect is 0.1-0.4 µg/mL in the presence of 16 ng/mL of recombinant human BDNF.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
Q16620.1
applications :
Bioactivity
source :
NS0-derived Recombinant Human TrkB Fc Chimera Protein, CF
USD :
438 USD
alt names :
BDNF/NT-3 growth factors receptor, EC 2.7.10, EC 2.7.10.1, GP145-TrkB, Neurotrophic tyrosine kinase receptor type 2, neurotrophic tyrosine kinase, receptor, type 2, NTRK2, trk-B, TrkB tyrosine kinase, TRKBBDNF-tropomyosine receptor kinase B, tyrosine kinase receptor B
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.