Recombinant Human FGFR4 Fc Chimera Protein, CF | R&D Systems 685-FR-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human FGFR4 Fc Chimera Protein, CF

catalog :

685-FR-050

quantity :

50 ug

price :

468 USD

more info or order :

R&D Systems product webpage

citations: 5

Reference
Yanucil C, Kentrup D, Li X, Grabner A, Schramm K, Martinez E, et al. FGF21-FGFR4 signaling in cardiac myocytes promotes concentric cardiac hypertrophy in mouse models of diabetes. Sci Rep. 2022;12:7326 pubmed publisher
Bartz R, Fukuchi K, Ohtsuka T, Lange T, Grüner K, Watanabe I, et al. Preclinical Development of U3-1784, a Novel FGFR4 Antibody Against Cancer, and Avoidance of Its On-target Toxicity. Mol Cancer Ther. 2019;18:1832-1843 pubmed publisher
Agrawal A, Parlee S, Perez Tilve D, Li P, Pan J, Mroz P, et al. Molecular elements in FGF19 and FGF21 defining KLB/FGFR activity and specificity. Mol Metab. 2018;13:45-55 pubmed publisher
Marklund M, Sjödal M, Beehler B, Jessell T, Edlund T, Gunhaga L. Retinoic acid signalling specifies intermediate character in the developing telencephalon. Development. 2004;131:4323-32 pubmed
Gunhaga L, Marklund M, Sjödal M, Hsieh J, Jessell T, Edlund T. Specification of dorsal telencephalic character by sequential Wnt and FGF signaling. Nat Neurosci. 2003;6:701-7 pubmed

product information

master code :

685-FR

SKU :

685-FR-050

product name :

Recombinant Human FGFR4 Fc Chimera Protein, CF

unit size :

50 ug

description :

The Recombinant Human FGFR4 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human FGFR4 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

FGFR4

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

observed molecular weight :

100-110 kDa, reducing conditions

theoretical molecular weight :

65 kDa (monomer)

gene symbol :

FGFR4

details of functionality :

Measured by its ability to inhibit FGF acidic-dependent proliferation of NR6R-3T3 mouse fibroblast cells. The ED50 for this effect is 2-6áng/mL.

endotoxin note :

<0.01 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P22455

applications :

Bioactivity

source long :

Mouse myeloma cell line, NS0-derived human FGFR4 protein Human FGF R4 (Leu22-Asp369) Accession # P22455 IEGRMD Human IgG1 (Pro100-Lys330) N-terminus C-terminus

source short :

NS0

USD :

468 USD

alt names :

CD334, CD334 antigen, EC 2.7.10, EC 2.7.10.1, FGF R4, FGFR-4, fibroblast growth factor receptor 4, JTK2hydroxyaryl-protein kinase, MGC20292, protein-tyrosine kinase, TKF, tyrosine kinase related to fibroblast growth factor receptor, tyrosylprotein kinase

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage