Recombinant Human sFRP-2 Protein | R&D Systems 6838-FR-025 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human sFRP-2 Protein

catalog :

6838-FR-025

quantity :

25 ug

price :

525 USD

more info or order :

R&D Systems product webpage

citations: 8

Reference
Cohen M, Brumwell A, Che Ho T, Montas G, Golden J, Jones K, et al. A fibroblast-dependent TGFβ1/sFRP2 noncanonical Wnt signaling axis underlies epithelial metaplasia in idiopathic pulmonary fibrosis. bioRxiv. 2023;: pubmed publisher
Hsueh Y, Pratt R, Dzau V, Hodgkinson C. Novel method of differentiating human induced pluripotent stem cells to mature cardiomyocytes via Sfrp2. Sci Rep. 2023;13:3920 pubmed publisher
Jayabal P, Zhou F, Ma X, Bondra K, Blackman B, Weintraub S, et al. Nitric oxide suppression by secreted frizzled-related protein 2 drives retinoblastoma. Cell Rep. 2023;42:112103 pubmed publisher
Ledwon J, Vaca E, Huang C, Kelsey L, McGrath J, Topczewski J, et al. Langerhans cells and SFRP2/Wnt/beta-catenin signalling control adaptation of skin epidermis to mechanical stretching. J Cell Mol Med. 2022;26:764-775 pubmed publisher
Liu G, Yan T, Li X, Sun J, Zhang B, Wang H, et al. Daam1 activates RhoA to regulate Wnt5a?induced glioblastoma cell invasion. Oncol Rep. 2017;: pubmed publisher
Zhang A, Yan T, Wang K, Huang Z, Liu J. PI3Kα isoform-dependent activation of RhoA regulates Wnt5a-induced osteosarcoma cell migration. Cancer Cell Int. 2017;17:27 pubmed publisher
Kim M, Han J, Kim J, Park T, Kang H. Secreted Frizzled-Related Protein 2 (sFRP2) Functions as a Melanogenic Stimulator; the Role of sFRP2 in UV-Induced Hyperpigmentary Disorders. J Invest Dermatol. 2016;136:236-44 pubmed publisher
Carthy J, EngstrÃ¶m U, Heldin C, Moustakas A. Commercially Available Preparations of Recombinant Wnt3a Contain Non-Wnt Related Activities Which May Activate TGF-Î² Signaling. J Cell Biochem. 2016;117:938-45 pubmed publisher

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

6838-FR

SKU :

6838-FR-025

product name :

Recombinant Human sFRP-2 Protein

Description :

The Recombinant Human sFRP-2 Protein from R&D Systems is derived from NS0. The Recombinant Human sFRP-2 Protein has been validated for the following applications: Bioactivity.

target :

sFRP-2

category :

Proteins and Enzymes

unit size :

25 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS and NaCl with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

34-36 kDa, reducing conditions

theoretical molecular weight :

31 kDa

gene symbol :

SFRP2

details of functionality :

Measured by its ability to synergize with Wnt-3a to induce Topflash reporter activity in HEK293T human embryonic kidney cells. The ED50 for this effect is 10-40 ng/mL in the presence of 20 ng/mL of Recombinant Mouse Wnt-3a (Catalog # 1324-WN ).

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

AAH08666

applications :

Bioactivity

source :

NS0-derived Recombinant Human sFRP-2 Protein

USD :

525 USD

alt names :

FRP2, FRP-2secreted apoptosis related protein 1, SARP-1, SARP1sFRP-2, SDF-5, Secreted apoptosis-related protein 1, secreted frizzled-related protein 2, sFRP2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage