product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human IL-36 gamma/IL-1F9 (aa 18-169) Protein, CF
catalog :
6835-IL-010/CF
quantity :
10 ug
price :
400 USD
more info or order :
R&D Systems product webpage
citations: 10
Reference
Muller A, Dickmanns A, Resch C, Schakel K, Hailfinger S, Dobbelstein M, et al. The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis. J Clin Invest. 2020;: pubmed publisher
Heath J, Scholz G, Veith P, Reynolds E. IL-36γ regulates mediators of tissue homeostasis in epithelial cells. Cytokine. 2019;119:24-31 pubmed publisher
Guo J, Tu J, Hu Y, Song G, Yin Z. Cathepsin G cleaves and activates IL-36γ and promotes the inflammation of psoriasis. Drug Des Devel Ther. 2019;13:581-588 pubmed publisher
Mercurio L, Morelli M, Scarponi C, Eisenmesser E, Doti N, Pagnanelli G, et al. IL-38 has an anti-inflammatory action in psoriasis and its expression correlates with disease severity and therapeutic response to anti-IL-17A treatment. Cell Death Dis. 2018;9:1104 pubmed publisher
Stanfield B, Rider P, Caskey J, Del Piero F, Kousoulas K. Intramuscular vaccination of guinea pigs with the live-attenuated human herpes simplex vaccine VC2 stimulates a transcriptional profile of vaginal Th17 and regulatory Tr1 responses. Vaccine. 2018;36:2842-2849 pubmed publisher
Swindell W, Beamer M, Sarkar M, Loftus S, Fullmer J, Xing X, et al. RNA-Seq Analysis of IL-1B and IL-36 Responses in Epidermal Keratinocytes Identifies a Shared MyD88-Dependent Gene Signature. Front Immunol. 2018;9:80 pubmed publisher
Wang W, Yu X, Wu C, Jin H. IL-36γ inhibits differentiation and induces inflammation of keratinocyte via Wnt signaling pathway in psoriasis. Int J Med Sci. 2017;14:1002-1007 pubmed publisher
Yi G, Ybe J, Saha S, Caviness G, Raymond E, Ganesan R, et al. Structural and Functional Attributes of the Interleukin-36 Receptor. J Biol Chem. 2016;291:16597-609 pubmed publisher
Saha S, Singh D, Raymond E, Ganesan R, Caviness G, Grimaldi C, et al. Signal Transduction and Intracellular Trafficking by the Interleukin 36 Receptor. J Biol Chem. 2015;290:23997-4006 pubmed publisher
Scheiermann P, Bachmann M, Härdle L, Pleli T, Piiper A, Zwissler B, et al. Application of IL-36 receptor antagonist weakens CCL20 expression and impairs recovery in the late phase of murine acetaminophen-induced liver injury. Sci Rep. 2015;5:8521 pubmed publisher
product information
master code :
6835-IL/CF
SKU :
6835-IL-010/CF
product name :
Recombinant Human IL-36 gamma/IL-1F9 (aa 18-169) Protein, CF
unit size :
10 ug
description :
The Recombinant Human IL-36 gamma/IL-1F9 (aa 18-169) Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human IL-36 gamma/IL-1F9 (aa 18-169) Protein, CF has been validated for the following applications: Bioactivity.
target :
IL-36 gamma/IL-1F9
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in MOPS, NaCl, TCEP and EDTA.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Human
observed molecular weight :
17 kDa, reducing coditions
theoretical molecular weight :
17 kDa
gene symbol :
IL36G
details of functionality :
Measured by its ability to induce IL-8 secretion in A431 human epithelial carcinoma cells. The ED50 for for this effect is 1.5-9 ng/mL.
endotoxin note :
<0.01 EU per 1 ╡g of the protein by the LAL method.
top caption :
Recombinant Human IL-36 gamma/IL-1F9 (aa 18-169) Protein Bioactivity
accessionNumbers :
Q9NZH8
applications :
Bioactivity
source long :
E. coli -derived human IL-36 gamma/IL-1F9 protein Ser18-Asp169
source short :
E. coli
USD :
400 USD
alt names :
IL-1 epsilon, IL-1 H1, IL-1 Related Protein 2, IL-1(EPSILON), IL1E, IL-1-epsilon, IL1F9, IL-1F9, IL1H1, IL-1H1, IL-1-Related Protein 2, IL1RP2, IL-1RP2, IL36 gamma, IL36G, interleukin 1 family, member 9, interleukin 1-related protein 2, Interleukin 36, Gamma, Interleukin-1 epsilon, interleukin-1 family member 9, Interleukin-1 homolog 1, Interleukin-36 Gamma
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.