Recombinant Human PDGF R alpha Fc Chimera Protein, CF | R&D Systems 6765-PR-050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human PDGF R alpha Fc Chimera Protein, CF

catalog :

6765-PR-050

quantity :

50 ug

price :

468 USD

citations: 4

Reference
Braun B, Laib Sampaio K, Kuderna A, Widmann M, Sinzger C. Viral and Cellular Factors Contributing to the Hematogenous Dissemination of Human Cytomegalovirus via Polymorphonuclear Leukocytes. Viruses. 2022;14: pubmed publisher
Park J, Gill K, Aghajani A, Heredia J, Choi H, Oberstein A, et al. Engineered receptors for human cytomegalovirus that are orthogonal to normal human biology. PLoS Pathog. 2020;16:e1008647 pubmed publisher
Stegmann C, Hochdorfer D, Lieber D, Subramanian N, Stöhr D, Laib Sampaio K, et al. A derivative of platelet-derived growth factor receptor alpha binds to the trimer of human cytomegalovirus and inhibits entry into fibroblasts and endothelial cells. PLoS Pathog. 2017;13:e1006273 pubmed publisher
Wu Y, Prager A, Boos S, Resch M, Brizic I, Mach M, et al. Human cytomegalovirus glycoprotein complex gH/gL/gO uses PDGFR-α as a key for entry. PLoS Pathog. 2017;13:e1006281 pubmed publisher

product information

master code :

6765-PR

SKU :

6765-PR-050

product name :

Recombinant Human PDGF R alpha Fc Chimera Protein, CF

unit size :

50 ug

description :

The Recombinant Human PDGF R alpha Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human PDGF R alpha Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

PDGF R alpha

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

110-130 kDa, reducing conditions

theoretical molecular weight :

82.8 kDa (monomer)

gene symbol :

PDGFRA

details of functionality :

Measured by its ability to inhibit the biological activity of PDGF-AB or PDGF-AA using NR6R-3T3 mouse fibroblast cells. Raines, E.W. et al . (1985) Methods Enzymol. 109 :749. The ED50 for this effect is 0.2-1 ╡g/mL in the presence of 100 ng/mL recombinant human PDGF-AB.

endotoxin note :

<0.01 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P16234

applications :

Bioactivity

source long :

Mouse myeloma cell line, NS0-derived human PDGF R alpha protein Human PDGF R alpha (Met1 - Glu524) Accession # P16234 IEGRMD Human IgG1 (Pro100 - Lys330) N-terminus C-terminus

source short :

NS0

USD :

468 USD

alt names :

alpha-type platelet-derived growth factor receptor, CD140 antigen-like family member A, CD140a, CD140a antigen, EC 2.7.10, EC 2.7.10.1, MGC74795, PDGFR alpha, PDGFR2, PDGFRA, PDGFRA/BCR fusion, PDGF-R-alpha, platelet-derived growth factor receptor, alpha polypeptide, rearranged-in-hypereosinophilia-platelet derived growth factor receptor alphafusion protein, RHEPDGFRA

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.