Recombinant Human CXCL11/I-TAC Protein, CF | R&D Systems 672-IT-025/CF product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human CXCL11/I-TAC Protein, CF

catalog :

672-IT-025/CF

quantity :

25 ug

price :

377 USD

more info or order :

R&D Systems product webpage

citations: 16

Reference
Kim S, Chu Y, Misoi M, Suarez Almazor M, Tayar J, Lu H, et al. Distinct molecular and immune hallmarks of inflammatory arthritis induced by immune checkpoint inhibitors for cancer therapy. Nat Commun. 2022;13:1970 pubmed publisher
Lotfi N, Zhang G, Esmaeil N, Rostami A. Evaluation of the effect of GM-CSF blocking on the phenotype and function of human monocytes. Sci Rep. 2020;10:1567 pubmed publisher
Caccuri F, Bugatti A, Corbellini S, Roversi S, Zani A, Mazzuca P, et al. The Synthetic Dipeptide Pidotimod Shows a Chemokine-Like Activity through CXC Chemokine Receptor 3 (CXCR3). Int J Mol Sci. 2019;20: pubmed publisher
Hsiao J, Ng B, Smits M, Wang J, Jasavala R, Martinez H, et al. Androgen receptor and chemokine receptors 4 and 7 form a signaling axis to regulate CXCL12-dependent cellular motility. BMC Cancer. 2015;15:204 pubmed publisher
Liu C, Pham K, Luo D, Reynolds B, Hothi P, Foltz G, et al. Expression and functional heterogeneity of chemokine receptors CXCR4 and CXCR7 in primary patient-derived glioblastoma cells. PLoS ONE. 2013;8:e59750 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Berahovich R, Zabel B, Penfold M, Lewén S, Wang Y, Miao Z, et al. CXCR7 protein is not expressed on human or mouse leukocytes. J Immunol. 2010;185:5130-9 pubmed publisher
Leick M, Catusse J, Follo M, Nibbs R, Hartmann T, Veelken H, et al. CCL19 is a specific ligand of the constitutively recycling atypical human chemokine receptor CRAM-B. Immunology. 2010;129:536-46 pubmed publisher
Hartl D, Krauss Etschmann S, Koller B, Hordijk P, Kuijpers T, Hoffmann F, et al. Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases. J Immunol. 2008;181:8053-67 pubmed
Loos T, Mortier A, Gouwy M, Ronsse I, Put W, Lenaerts J, et al. Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation. Blood. 2008;112:2648-56 pubmed publisher
Winter D, Moser J, Kriehuber E, Wiesner C, Knobler R, Trautinger F, et al. Down-modulation of CXCR3 surface expression and function in CD8+ T cells from cutaneous T cell lymphoma patients. J Immunol. 2007;179:4272-82 pubmed
Proost P, Mortier A, Loos T, Vandercappellen J, Gouwy M, Ronsse I, et al. Proteolytic processing of CXCL11 by CD13/aminopeptidase N impairs CXCR3 and CXCR7 binding and signaling and reduces lymphocyte and endothelial cell migration. Blood. 2007;110:37-44 pubmed
Nguyen A, Stebbins E, Henson M, O Young G, Choi S, Quon D, et al. Normalizing the bone marrow microenvironment with p38 inhibitor reduces multiple myeloma cell proliferation and adhesion and suppresses osteoclast formation. Exp Cell Res. 2006;312:1909-23 pubmed
Kohrgruber N, Groger M, Meraner P, Kriehuber E, Petzelbauer P, Brandt S, et al. Plasmacytoid dendritic cell recruitment by immobilized CXCR3 ligands. J Immunol. 2004;173:6592-602 pubmed
Liu L, Jarjour N, Busse W, Kelly E. Enhanced generation of helper T type 1 and 2 chemokines in allergen-induced asthma. Am J Respir Crit Care Med. 2004;169:1118-24 pubmed
Wan Y, Jakway J, Qiu H, Shah H, Garlisi C, Tian F, et al. Identification of full, partial and inverse CC chemokine receptor 3 agonists using [35S]GTPgammaS binding. Eur J Pharmacol. 2002;456:1-10 pubmed

product information

brand :

R&D Systems

master code :

672-IT/CF

SKU :

672-IT-025/CF

product name :

Recombinant Human CXCL11/I-TAC Protein, CF

description :

The Recombinant Human CXCL11/I-TAC Protein, CF from R&D Systems is derived from E. coli.

target :

CXCL11/I-TAC

category :

Proteins and Enzymes

unit sizes :

25 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

theoretical molecular weight :

8.3 kDa

gene symbol :

CXCL11

details of functionality :

Measured by its ability to chemoattract BaF3 mouse pro-B cells transfected with human CXCR3. The ED50 for this effect is 1-5 ng/mL.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

O14625

source :

E. coli-derived Recombinant Human CXCL11/I-TAC Protein, CF

USD :

377 USD

alt names :

beta-R1, b-R1, chemokine (C-X-C motif) ligand 11, H174, H174IP9, Interferon gamma-inducible protein 9, Interferon-inducible T-cell alpha chemoattractant, IP-9member 11, ITAC, I-TAC, I-TACMGC102770, SCYB9B, small inducible cytokine subfamily B (Cys-X-Cys), member 9B, Small-inducible cytokine B11

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage