product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human gp130 Fc Chimera Protein, CF
catalog :
671-GP-100
quantity :
100 ug
price :
423 USD
more info or order :
R&D Systems product webpage
citations: 10
Reference
Mosly D, MacLeod K, Moir N, Turnbull A, Sims A, Langdon S. Variation in IL6ST cytokine family function and the potential of IL6 trans-signalling in ERα positive breast cancer cells. Cell Signal. 2023;103:110563 pubmed publisher
Lindkvist M, Zegeye M, Greneg xe5 rd M, Ljungberg L. Pleiotropic, Unique and Shared Responses Elicited by IL-6 Family Cytokines in Human Vascular Endothelial Cells. Int J Mol Sci. 2022;23: pubmed publisher
Dong J, Viswanathan S, Adami E, Singh B, Chothani S, Ng B, et al. Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH. Nat Commun. 2021;12:66 pubmed publisher
Robinson R, Brown D, Churchwell L, Lee T, Kodeboyina S, Bloom J, et al. RNA-Seq analysis reveals gene expression changes induced by IL-6 trans-signaling activation in retinal endothelial cells. Cytokine. 2021;139:155375 pubmed publisher
Werner Klein M, Grujovic A, Irlbeck C, Obradovic M, Hoffmann M, Koerkel Qu H, et al. Interleukin-6 trans-signaling is a candidate mechanism to drive progression of human DCCs during clinical latency. Nat Commun. 2020;11:4977 pubmed publisher
Findeisen M, Allen T, Henstridge D, Kammoun H, Brandon A, Baggio L, et al. Treatment of type 2 diabetes with the designer cytokine IC7Fc. Nature. 2019;574:63-68 pubmed publisher
Dietrich C, Candon S, Ruemmele F, Devergne O. A soluble form of IL-27R? is a natural IL-27 antagonist. J Immunol. 2014;192:5382-9 pubmed publisher
Chollangi S, Mather T, Rodgers K, Ash J. A unique loop structure in oncostatin M determines binding affinity toward oncostatin M receptor and leukemia inhibitory factor receptor. J Biol Chem. 2012;287:32848-59 pubmed
Abir R, Fisch B, Jin S, Barnnet M, Freimann S, van den Hurk R, et al. Immunocytochemical detection and RT-PCR expression of leukaemia inhibitory factor and its receptor in human fetal and adult ovaries. Mol Hum Reprod. 2004;10:313-9 pubmed
McLoughlin R, Witowski J, Robson R, Wilkinson T, Hurst S, Williams A, et al. Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation. J Clin Invest. 2003;112:598-607 pubmed
product information
brand :
R&D Systems, a Bio-Techne Brand
catalog number base :
671-GP
SKU :
671-GP-100
product name :
Recombinant Human gp130 Fc Chimera Protein, CF
Description :
The Recombinant Human gp130 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human gp130 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.
target :
gp130
category :
Proteins and Enzymes
unit size :
100 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS.
conjugate :
Unconjugated
purity :
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Human
observed molecular weight :
115-130 kDa, reducing conditions
theoretical molecular weight :
95 kDa (monomer)
gene symbol :
IL6ST
details of functionality :
Measured by its ability to inhibit IL-6-dependent proliferation of the 7TD1 mouse hybridoma cells in the presence of Recombinant Human IL-6 R alpha (Catalog # 227-SR ). The ED50 for this effect is 0.65-6.5 ng/mL.
endotoxin note :
<0.01 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
P40189
applications :
Bioactivity
source :
NS0-derived Recombinant Human gp130 Fc Chimera Protein
USD :
423 USD
alt names :
CD130, CD130 antigen, CDw130, DKFZp564F053, gp130, gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form, IL-6 receptor subunit beta, IL-6R subunit beta, IL-6RB, IL-6R-beta, IL6ST, interleukin 6 signal transducer (gp130, oncostatin M receptor), interleukin receptor beta chain, interleukin-6 receptor subunit beta, Interleukin-6 signal transducer, Membrane glycoprotein 130, membrane glycoprotein gp130, Oncostatin-M receptor subunit alpha
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.