Recombinant Human Follistatin 300 Protein, CF | R&D Systems 669-FO-025/CF product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Follistatin 300 Protein, CF

catalog :

669-FO-025/CF

quantity :

25 ug

price :

420 USD

more info or order :

R&D Systems product webpage

citations: 16

Reference
Morabito M, Larcher M, Cavalli F, Foray C, Forget A, Mirabal Ortega L, et al. An autocrine ActivinB mechanism drives TGFβ/Activin signaling in Group 3 medulloblastoma. EMBO Mol Med. 2019;11:e9830 pubmed publisher
Jørgensen A, Macdonald J, Nielsen J, Kilcoyne K, Perlman S, Lundvall L, et al. Nodal Signaling Regulates Germ Cell Development and Establishment of Seminiferous Cords in the Human Fetal Testis. Cell Rep. 2018;25:1924-1937.e4 pubmed publisher
Li J, Xing F, Chen F, He L, So K, Liu Y, et al. Functional 3D Human Liver Bud Assembled from MSC-Derived Multiple Liver Cell Lineages. Cell Transplant. 2019;28:510-521 pubmed publisher
De Berdt P, Bottemanne P, Bianco J, Alhouayek M, Diogenes A, Lloyd A, et al. Stem cells from human apical papilla decrease neuro-inflammation and stimulate oligodendrocyte progenitor differentiation via activin-A secretion. Cell Mol Life Sci. 2018;75:2843-2856 pubmed publisher
Hu J, Wang X, Tang Y, Shan Y, Zou Q, Wang Z, et al. Activin A inhibition attenuates sympathetic neural remodeling following myocardial infarction in rats. Mol Med Rep. 2018;17:5074-5080 pubmed publisher
Ashry M, Rajput S, Folger J, Knott J, Hemeida N, Kandil O, et al. Functional role of AKT signaling in bovine early embryonic development: potential link to embryotrophic actions of follistatin. Reprod Biol Endocrinol. 2018;16:1 pubmed publisher
Staudacher J, Yazici C, Carroll T, Bauer J, Pang J, Krett N, et al. Activin in acute pancreatitis: Potential risk-stratifying marker and novel therapeutic target. Sci Rep. 2017;7:12786 pubmed publisher
Seachrist D, Sizemore S, Johnson E, Abdul Karim F, Weber Bonk K, Keri R. Follistatin is a metastasis suppressor in a mouse model of HER2-positive breast cancer. Breast Cancer Res. 2017;19:66 pubmed publisher
Kadiombo A, Maeshima A, Kayakabe K, Ikeuchi H, Sakairi T, Kaneko Y, et al. Involvement of infiltrating macrophage-derived activin A in the progression of renal damage in MRL-lpr mice. Am J Physiol Renal Physiol. 2017;312:F297-F304 pubmed publisher
Jeanpierre S, Nicolini F, Kaniewski B, Dumontet C, Rimokh R, Puisieux A, et al. BMP4 regulation of human megakaryocytic differentiation is involved in thrombopoietin signaling. Blood. 2008;112:3154-63 pubmed publisher
Alexander S, Watt F, Sawaji Y, Hermansson M, Saklatvala J. Activin A is an anticatabolic autocrine cytokine in articular cartilage whose production is controlled by fibroblast growth factor 2 and NF-kappaB. Arthritis Rheum. 2007;56:3715-25 pubmed
Wen Z, Han L, Bamburg J, Shim S, Ming G, Zheng J. BMP gradients steer nerve growth cones by a balancing act of LIM kinase and Slingshot phosphatase on ADF/cofilin. J Cell Biol. 2007;178:107-19 pubmed publisher
McLean A, D Amour K, Jones K, Krishnamoorthy M, Kulik M, Reynolds D, et al. Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed. Stem Cells. 2007;25:29-38 pubmed
Silva J, Tharasanit T, Taverne M, van der Weijden G, Santos R, Figueiredo J, et al. The activin-follistatin system and in vitro early follicle development in goats. J Endocrinol. 2006;189:113-25 pubmed
Abe Y, Abe T, Aida Y, Hara Y, Maeda K. Follistatin restricts bone morphogenetic protein (BMP)-2 action on the differentiation of osteoblasts in fetal rat mandibular cells. J Bone Miner Res. 2004;19:1302-7 pubmed
Amthor H, Nicholas G, McKinnell I, Kemp C, Sharma M, Kambadur R, et al. Follistatin complexes Myostatin and antagonises Myostatin-mediated inhibition of myogenesis. Dev Biol. 2004;270:19-30 pubmed

product information

brand :

R&D Systems, a Bio-Techne brand

catalog number base :

669-FO/CF

SKU :

669-FO-025/CF

product name :

Recombinant Human Follistatin 300 Protein, CF

description :

The Recombinant Human Follistatin 300 Protein, CF from R&D Systems is derived from Sf 21 (baculovirus). The Recombinant Human Follistatin 300 Protein, CF has been validated for the following applications: Bioactivity.

target :

Follistatin

unit size :

25 ug

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

observed molecular weight :

38-43 kDa, reducing conditions

theoretical molecular weight :

31 kDa

gene symbol :

FST

details of functionality :

Measured by its ability to neutralize Activin-mediated erythroid differentiation of K562 human chronic myelogenous leukemia cells. The ED50 for this effect is 0.1-0.4 µg/mL in the presence of 7.5 ng/mL of rhActivin A.

endotoxin note :

<0.01 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

P19883

applications :

Bioactivity

product keywords :

669-FO, rhFollistatin, hFollistatin, carrier-free, carrier free, 669FO/CF, cytokine, cytokines

source :

Sf 21 (baculovirus)-derived Recombinant Human Follistatin 300 Protein, CF

USD :

408

USD 2025 :

420 USD

alt names :

follistatin, follistatin isoform FST317, FS, FSActivin-binding protein, FST

more info or order :

R&D Systems product webpage