Recombinant Human DNAM-1/CD226 Fc Chimera Protein, CF | R&D Systems 666-DN-050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human DNAM-1/CD226 Fc Chimera Protein, CF

catalog :

666-DN-050

quantity :

50 ug

price :

443 USD

citations: 4

Reference
Fittje P, H x153 lzemer A, Garcia Beltran W, Vollmers S, Niehrs A, Hagemann K, et al. HIV-1 Nef-mediated downregulation of CD155 results in viral restriction by KIR2DL5+ NK cells. PLoS Pathog. 2022;18:e1010572 pubmed publisher
Joung J, Kirchgatterer P, Singh A, Cho J, Nety S, Larson R, et al. CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity. Nat Commun. 2022;13:1606 pubmed publisher
Nakano M, Ayano M, Kushimoto K, Kawano S, Higashioka K, Inokuchi S, et al. Association of elevated serum soluble CD226 levels with the disease activity and flares of systemic lupus erythematosus. Sci Rep. 2021;11:16162 pubmed publisher
Oda T, Ohka S, Nomoto A. Ligand stimulation of CD155alpha inhibits cell adhesion and enhances cell migration in fibroblasts. Biochem Biophys Res Commun. 2004;319:1253-64 pubmed

product information

master code :

666-DN

SKU :

666-DN-050

product name :

Recombinant Human DNAM-1/CD226 Fc Chimera Protein, CF

unit size :

50 ug

description :

The Recombinant Human DNAM-1/CD226 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human DNAM-1/CD226 Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.

target :

DNAM-1/CD226

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

observed molecular weight :

75-80 kDa, reducing conditions

theoretical molecular weight :

53 kDa (monomer)

gene symbol :

CD226

details of functionality :

Measured by its binding ability in a functional ELISA. When Recombinant Human DNAM-1/CD226Fc Chimera is immobilized at 1 ╡g/mL, 100 ╡L/well, it binds Biotinylated Recombinant Human CD155/PVR Fc Chimera (Catalog # BT9174) with an ED50 of 3-18 ng/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

top caption :

Recombinant Human DNAM-1/CD226 Fc Chimera Protein Binding Activity

accessionNumbers :

Q15762

applications :

Binding Activity

source long :

Mouse myeloma cell line, NS0-derived human DNAM-1/CD226 protein Human DNAM-1/CD226 (Glu19-Asn247) Accession # Q15762 HIEGRMD Human IgG1 (Pro100-Lys330) N-terminus C-terminus

source short :

NS0

USD :

443 USD

alt names :

CD226, CD226 antigenplatelet and T cell activation antigen 1, CD226 molecule, DNAM1, DNAM1adhesion glycoprotein, DNAM-1DNAX accessory molecule-1, DNAX accessory molecule 1, PTA1, T lineage-specific activation antigen 1 antigen, TLiSA1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.