product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human DNAM-1/CD226 Fc Chimera Protein, CF
catalog :
666-DN-050
quantity :
50 ug
price :
434 USD
more info or order :
R&D Systems product webpage
citations: 4
Reference
Fittje P, H x153 lzemer A, Garcia Beltran W, Vollmers S, Niehrs A, Hagemann K, et al. HIV-1 Nef-mediated downregulation of CD155 results in viral restriction by KIR2DL5+ NK cells. PLoS Pathog. 2022;18:e1010572 pubmed publisher
Joung J, Kirchgatterer P, Singh A, Cho J, Nety S, Larson R, et al. CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity. Nat Commun. 2022;13:1606 pubmed publisher
Nakano M, Ayano M, Kushimoto K, Kawano S, Higashioka K, Inokuchi S, et al. Association of elevated serum soluble CD226 levels with the disease activity and flares of systemic lupus erythematosus. Sci Rep. 2021;11:16162 pubmed publisher
Oda T, Ohka S, Nomoto A. Ligand stimulation of CD155alpha inhibits cell adhesion and enhances cell migration in fibroblasts. Biochem Biophys Res Commun. 2004;319:1253-64 pubmed
image
image 1 :
R&D Systems 666-DN-050 image 1
Recombinant Human DNAM-1/CD226 Fc Chimera Protein Binding Activity
product information
brand :
R&D Systems, a Bio-Techne Brand
catalog number base :
666-DN
SKU :
666-DN-050
product name :
Recombinant Human DNAM-1/CD226 Fc Chimera Protein, CF
Description :
The Recombinant Human DNAM-1/CD226 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human DNAM-1/CD226 Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.
target :
DNAM-1/CD226
category :
Proteins and Enzymes
unit size :
50 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Human
observed molecular weight :
75-80 kDa, reducing conditions
theoretical molecular weight :
53 kDa (monomer)
gene symbol :
CD226
details of functionality :
Measured by its binding ability in a functional ELISA. When Recombinant Human DNAM-1/CD226Fc Chimera is immobilized at 1 µg/mL, 100 µL/well, it binds Biotinylated Recombinant Human CD155/PVR Fc Chimera (Catalog # BT9174) with an ED50 of 3-18 ng/mL.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
Q15762
applications :
Binding Activity
source :
NS0-derived Recombinant Human DNAM-1/CD226 Fc Chimera Protein
USD :
434 USD
alt names :
CD226, CD226 antigenplatelet and T cell activation antigen 1, CD226 molecule, DNAM1, DNAM1adhesion glycoprotein, DNAM-1DNAX accessory molecule-1, DNAX accessory molecule 1, PTA1, T lineage-specific activation antigen 1 antigen, TLiSA1
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.