product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human LIGHT/TNFSF14 Protein, CF
catalog :
664-LI-025/CF
quantity :
25 ug
price :
377 USD
more info or order :
R&D Systems product webpage
citations: 18
Reference
Heo S, Choi Y, Jeong Y, Ju L, Yu H, Kim D, et al. LIGHT (TNFSF14) enhances osteogenesis of human bone marrow-derived mesenchymal stem cells. PLoS ONE. 2021;16:e0247368 pubmed publisher
Jang H, Park S, Kim J, Kim J, Kim S, Cho S, et al. The Tumor Suppressor, p53, Negatively Regulates Non-Canonical NF-κB Signaling through miRNAInduced Silencing of NF-κB-Inducing Kinase. Mol Cells. 2020;43:23-33 pubmed publisher
An S, Raju I, Surenkhuu B, Kwon J, Gulati S, Karaman M, et al. Neutrophil extracellular traps (NETs) contribute to pathological changes of ocular graft-vs.-host disease (oGVHD) dry eye: Implications for novel biomarkers and therapeutic strategies. Ocul Surf. 2019;: pubmed publisher
Kim K, Choi H, Kim H, Lee T. TNFSF14 inhibits melanogenesis via NF-kB signaling in melanocytes. Cytokine. 2018;110:126-130 pubmed publisher
da Silva Antunes R, Mehta A, Madge L, Tocker J, Croft M. TNFSF14 (LIGHT) Exhibits Inflammatory Activities in Lung Fibroblasts Complementary to IL-13 and TGF-β. Front Immunol. 2018;9:576 pubmed publisher
Clarke A, Poulton L, Shim D, Mabon D, Butt D, Pollard M, et al. An anti-TL1A antibody for the treatment of asthma and inflammatory bowel disease. MAbs. 2018;10:664-677 pubmed publisher
Abadpour S, Halvorsen B, Sahraoui A, Korsgren O, Aukrust P, Scholz H. Interleukin-22 reverses human islet dysfunction and apoptosis triggered by hyperglycemia and LIGHT. J Mol Endocrinol. 2018;60:171-183 pubmed publisher
Yuan X, Gu Y, Lai X, Gu Q. LIGHT is increased in patients with coronary disease and regulates inflammatory response and lipid metabolism in oxLDL-induced THP-1 macrophages. Biochem Biophys Res Commun. 2017;490:732-738 pubmed publisher
Sibilano R, Gaudenzio N, DeGorter M, Reber L, Hernandez J, Starkl P, et al. A TNFRSF14-Fc?RI-mast cell pathway contributes to development of multiple features of asthma pathology in mice. Nat Commun. 2016;7:13696 pubmed publisher
Heo S, Noh E, Gwon G, Kim J, Jo J, Choi Y, et al. LIGHT (TNFSF14) Increases the Survival and Proliferation of Human Bone Marrow-Derived Mesenchymal Stem Cells. PLoS ONE. 2016;11:e0166589 pubmed publisher
da Silva Antunes R, Madge L, Soroosh P, Tocker J, Croft M. The TNF Family Molecules LIGHT and Lymphotoxin αβ Induce a Distinct Steroid-Resistant Inflammatory Phenotype in Human Lung Epithelial Cells. J Immunol. 2015;195:2429-41 pubmed publisher
Herro R, Antunes R, Aguilera A, Tamada K, Croft M. The Tumor Necrosis Factor Superfamily Molecule LIGHT Promotes Keratinocyte Activity and Skin Fibrosis. J Invest Dermatol. 2015;135:2109-2118 pubmed publisher
Mikami Y, Matsuzaki H, Horie M, Noguchi S, Jo T, Narumoto O, et al. Lymphotoxin β receptor signaling induces IL-8 production in human bronchial epithelial cells. PLoS ONE. 2014;9:e114791 pubmed publisher
Jin H, Jin X, Lee J. Zinc-finger protein 91 plays a key role in LIGHT-induced activation of non-canonical NF-?B pathway. Biochem Biophys Res Commun. 2010;400:581-6 pubmed publisher
Sandberg W, Halvorsen B, Yndestad A, Smith C, Otterdal K, Brosstad F, et al. Inflammatory interaction between LIGHT and proteinase-activated receptor-2 in endothelial cells: potential role in atherogenesis. Circ Res. 2009;104:60-8 pubmed publisher
Kang Y, Kim S, Kang J, Han S, Nam E, Kyung H, et al. LIGHT up-regulated on B lymphocytes and monocytes in rheumatoid arthritis mediates cellular adhesion and metalloproteinase production by synoviocytes. Arthritis Rheum. 2007;56:1106-17 pubmed
Otterdal K, Smith C, Oie E, Pedersen T, Yndestad A, Stang E, et al. Platelet-derived LIGHT induces inflammatory responses in endothelial cells and monocytes. Blood. 2006;108:928-35 pubmed
Edwards J, Sun S, Locklin R, Shipman C, Adamopoulos I, Athanasou N, et al. LIGHT (TNFSF14), a novel mediator of bone resorption, is elevated in rheumatoid arthritis. Arthritis Rheum. 2006;54:1451-62 pubmed
image
image 1 :
R&D Systems 664-LI-025/CF image 1
Recombinant Human LIGHT/TNFSF14 Protein Bioactivity
product information
brand :
R&D Systems
master code :
664-LI/CF
SKU :
664-LI-025/CF
product name :
Recombinant Human LIGHT/TNFSF14 Protein, CF
description :
The Recombinant Human LIGHT/TNFSF14 Protein, CF from R&D Systems is derived from NS0.
target :
LIGHT/TNFSF14
category :
Proteins and Enzymes
unit sizes :
25 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Human
observed molecular weight :
25 kDa, reducing conditions
theoretical molecular weight :
20.9 kDa
gene symbol :
TNFSF14
details of functionality :
Measured in a cell proliferation assay using HUVEC human umbilical vein endothelial cells. Conn, G. et al . (1990) Proc. Natl. Acad. Sci. USA 87 :1323. The ED50 for this effect is 0.3-3 ng/mL.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
O43557
source :
NS0-derived Recombinant Human LIGHT/TNFSF14 Protein, CF
USD :
377 USD
alt names :
CD258, CD258 antigen, delta transmembrane LIGHT, Herpes virus entry mediator ligand, Herpesvirus entry mediator ligand, HVEM-L, HVEMLherpesvirus entry mediator-ligand, ligand for herpesvirus entry mediator, LIGHTherpesvirus entry mediator A, LTg, TNFSF14, TR2, tumor necrosis factor (ligand) superfamily, member 14, tumor necrosis factor ligand superfamily member 14, tumor necrosis factor receptor-like 2, tumor necrosis factor superfamily member LIGHT
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.