Recombinant Mouse IGF-I R/IGF1R Protein, CF | R&D Systems 6630-GR-025/CF product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse IGF-I R/IGF1R Protein, CF

catalog :

6630-GR-025/CF

quantity :

25 ug

price :

432 USD

citations: 3

Reference
Yogi A, Hussack G, van Faassen H, Haqqani A, Delaney C, Brunette E, et al. Brain Delivery of IGF1R5, a Single-Domain Antibody Targeting Insulin-like Growth Factor-1 Receptor. Pharmaceutics. 2022;14: pubmed publisher
Solomon V, Alizadeh E, Bernhard W, Makhlouf A, Hartimath S, Hill W, et al. Development and preclinical evaluation of cixutumumab drug conjugates in a model of insulin growth factor receptor I (IGF-1R) positive cancer. Sci Rep. 2020;10:18549 pubmed publisher
De Giovanni C, Landuzzi L, Palladini A, Ianzano M, Nicoletti G, Ruzzi F, et al. Cancer Vaccines Co-Targeting HER2/Neu and IGF1R. Cancers (Basel). 2019;11: pubmed publisher

product information

master code :

6630-GR/CF

SKU :

6630-GR-025/CF

product name :

Recombinant Mouse IGF-I R/IGF1R Protein, CF

unit size :

25 ug

description :

The Recombinant Mouse IGF-I R/IGF1R Protein, CF from R&D Systems is derived from CHO. The Recombinant Mouse IGF-I R/IGF1R Protein, CF has been validated for the following applications: Bioactivity.

target :

IGF-I R/IGF1R

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Mouse

observed molecular weight :

160-170 kDa, 120-130 kDa 45-52 kDa, reducing conditions.

theoretical molecular weight :

104.5 kDa (single chain), 80.7 kDa ( alpha subunit) 23.2 kDa (▀ subunit)

details of functionality :

Measured by its binding ability in a functional ELISA. When Recombinant Mouse (rm) IGF-I R/IGF1R is present at 0.5 ╡g/mL, the concentration of rmIGF-I that produces 50% of the optimal binding response is found to be approximately 10-60 ng/mL.

endotoxin note :

<0.01 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q60751

applications :

Bioactivity

source long :

Chinese Hamster Ovary cell line, CHO-derived mouse IGF-I R/IGF1R protein Met1-His936, with a C-terminal 6-His tag

source short :

CHO

USD :

432 USD

alt names :

CD221, CD221 antigen, EC 2.7.10, EC 2.7.10.1, IGF1R, IGF-1R, IGF-I receptor, IGFIR, IGF-IR, IGFR, insulin-like growth factor 1 receptor, Insulin-like growth factor I receptor, JTK13, MGC142170, MGC142172, MGC18216, soluble IGF1R variant 1, soluble IGF1R variant 2

storage :

12 months from date of receipt, <= -20 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, <= -20 ░C under sterile conditions after reconstitution.